DegronMD

Uniprot ID: Q9BSJ2

Source protein: Gamma-tubulin complex component 2

Source gene: TUBGCP2

Class: DEG_APCC_DBOX_1

Location: 137:145

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9019

ASA_SCORE: 75.1889

COIL: 0.4184

CONS_SCORE: 0.3443

DSS_SCORE: 0.4123

HELIX: 0.5479

FCONS_SCORE: 1.0768

RIG_SCORE: 0.7298

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T146S	TCGA-37-5819	LUSC	TCGA	LRKQLGSVA	DEG_APCC_DBOX_1	0.3056
p.T146S	DO26479	LUSC	ICGC	LRKQLGSVA	DEG_APCC_DBOX_1	0.3056
p.M131I	TCGA-66-2756	LUSC	TCGA	LRKQLGSVA	DEG_APCC_DBOX_1	0.1667
p.M131I	DO27128	LUSC	ICGC	LRKQLGSVA	DEG_APCC_DBOX_1	0.1667
p.V144M	TCGA-G4-6304	COAD	TCGA	LRKQLGSVA	DEG_APCC_DBOX_1	0.6097
p.V144M	DO10639	COAD	ICGC	LRKQLGSVA	DEG_APCC_DBOX_1	0.6097
p.V144M	DO233913	GACA	ICGC	LRKQLGSVA	DEG_APCC_DBOX_1	0.6097
p.G142A	DO48385	BLCA	ICGC	LRKQLGSVA	DEG_APCC_DBOX_1	0.6429
p.Q152K	DO229032	LICA	ICGC	LRKQLGSVA	DEG_APCC_DBOX_1	0.1389
p.I129V	SIDM00863	Burkitt's Lymphoma	GDSC	LRKQLGSVA	DEG_APCC_DBOX_1	0.1111
p.I129V	ACH-000877	Lymphoma	CCLE	LRKQLGSVA	DEG_APCC_DBOX_1	0.1111
p.I129V	ACH-001064	Lymphoma	CCLE	LRKQLGSVA	DEG_APCC_DBOX_1	0.1111
p.I129V	EB2	haematopoietic_and_lymphoid_tissue	COSMIC	LRKQLGSVA	DEG_APCC_DBOX_1	0.1111
p.A128V	JEG-3	placenta	COSMIC	LRKQLGSVA	DEG_APCC_DBOX_1	0.1944
p.P142S	K2	skin	COSMIC	LRKQLGSVA	DEG_APCC_DBOX_1	0.6752
p.E131K	NCI-H2342	lung	COSMIC	LRKQLGSVA	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BSJ2	Gamma-tubulin complex component 2	DEG_APCC_DBOX_1	137:145	LRKQLGSVA	APC,CDC20,FZR1	0.9019	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons