DegronMD

Uniprot ID: P38398

Source protein: Breast cancer type 1 susceptibility protein

Source gene: BRCA1

Class: DEG_SCF_FBW7_2

Location: 1558:1565

E3 ligase: FBXW7

DEGRON score: 0.5212

ASA_SCORE: 88.275

COIL: 0.7963

CONS_SCORE: 0.3547

DSS_SCORE: 0.597

HELIX: 0.1103

FCONS_SCORE: 0.9667

RIG_SCORE: 0.6909

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1548D	TCGA-44-8119	LUAD	TCGA	LEGTPYLE	DEG_SCF_FBW7_2	0.5
p.E1557K	TCGA-DR-A0ZM	CESC	TCGA	LEGTPYLE	DEG_SCF_FBW7_2	0.3056
p.D1567N	SIDM01057	Acute Myeloid Leukemia	GDSC	LEGTPYLE	DEG_SCF_FBW7_2	0.2778
p.D1567N	GDM-1	haematopoietic_and_lymphoid_tissue	COSMIC	LEGTPYLE	DEG_SCF_FBW7_2	0.2778
p.S1563C	SIDM01139	Pancreatic Carcinoma	GDSC	LEGTPYLE	DEG_SCF_FBW7_2	0.7541
p.S1563C	PANC-02-03	pancreas	COSMIC	LEGTPYLE	DEG_SCF_FBW7_2	0.7541
p.V1555M	SIDM00844	Burkitt's Lymphoma	GDSC	LEGTPYLE	DEG_SCF_FBW7_2	0.25
p.T1548M	ACH-001127	Leukemia	CCLE	LEGTPYLE	DEG_SCF_FBW7_2	0.5
p.T1548M	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	LEGTPYLE	DEG_SCF_FBW7_2	0.5
p.D1557N	ACH-001451	Cervical Cancer	CCLE	LEGTPYLE	DEG_SCF_FBW7_2	0.3056
p.A1552V	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	LEGTPYLE	DEG_SCF_FBW7_2	0.6111
p.S1549A	NB14	autonomic_ganglia	COSMIC	LEGTPYLE	DEG_SCF_FBW7_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P38398	Breast cancer type 1 susceptibility protein	DEG_SCF_FBW7_2	1558:1565	LEGTPYLE	FBXW7	0.5212	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons