DegronMD

Uniprot ID: P38398

Source protein: Breast cancer type 1 susceptibility protein

Source gene: BRCA1

Class: LIG_APCC_ABBAyCdc20_2

Location: 175:181

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8923

ASA_SCORE: 80.7143

COIL: 0.5324

CONS_SCORE: 0.3863

DSS_SCORE: 0.4361

HELIX: 0.053

FCONS_SCORE: 0.924

RIG_SCORE: 0.8059

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K175N	TCGA-50-6593	LUAD	TCGA	KTSVYIE	LIG_APCC_ABBAyCdc20_2	0.6918
p.K175N	TCGA-CV-A6K2	HNSC	TCGA	KTSVYIE	LIG_APCC_ABBAyCdc20_2	0.6918
p.K175N	DO52079	HNSC	ICGC	KTSVYIE	LIG_APCC_ABBAyCdc20_2	0.6918
p.K175N	DO24100	LUAD	ICGC	KTSVYIE	LIG_APCC_ABBAyCdc20_2	0.6918
p.S184C	TCGA-CN-A6V1	HNSC	TCGA	KTSVYIE	LIG_APCC_ABBAyCdc20_2	0.6944
p.S184C	DO52048	HNSC	ICGC	KTSVYIE	LIG_APCC_ABBAyCdc20_2	0.6944
p.R170L	TCGA-DU-6404	LGG	TCGA	KTSVYIE	LIG_APCC_ABBAyCdc20_2	0.1944
p.R170L	DO22207	LGG	ICGC	KTSVYIE	LIG_APCC_ABBAyCdc20_2	0.1944
p.E181D	TCGA-XQ-A8TA	PRAD	TCGA	KTSVYIE	LIG_APCC_ABBAyCdc20_2	0.5647
p.E181D	DO223662	PRAD	ICGC	KTSVYIE	LIG_APCC_ABBAyCdc20_2	0.5647
p.T176M	DO229355	BTCA	ICGC	KTSVYIE	LIG_APCC_ABBAyCdc20_2	0.6312
p.T167K	DO228971	LICA	ICGC	KTSVYIE	LIG_APCC_ABBAyCdc20_2	0.1111
p.T190N	DO229022	LICA	ICGC	KTSVYIE	LIG_APCC_ABBAyCdc20_2	0.0833
p.S186Y	SIDM01039	Other Solid Cancers	GDSC	KTSVYIE	LIG_APCC_ABBAyCdc20_2	0.6389
p.S186Y	SIDM00793	Burkitt's Lymphoma	GDSC	KTSVYIE	LIG_APCC_ABBAyCdc20_2	0.6389
p.S186Y	SIDM00863	Burkitt's Lymphoma	GDSC	KTSVYIE	LIG_APCC_ABBAyCdc20_2	0.6389
p.S186Y	SIDM00721	Small Cell Lung Carcinoma	GDSC	KTSVYIE	LIG_APCC_ABBAyCdc20_2	0.6389
p.S186F	SIDM00665	Gastric Carcinoma	GDSC	KTSVYIE	LIG_APCC_ABBAyCdc20_2	0.6389
p.S186F	ACH-000616	Gastric Cancer	CCLE	KTSVYIE	LIG_APCC_ABBAyCdc20_2	0.6389
p.S186F	Hs746T	stomach	COSMIC	KTSVYIE	LIG_APCC_ABBAyCdc20_2	0.6389
p.R190Q	DMS-273	lung	COSMIC	KTSVYIE	LIG_APCC_ABBAyCdc20_2	0.0833
p.C188F	NCI-H2347	lung	COSMIC	KTSVYIE	LIG_APCC_ABBAyCdc20_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P38398	Breast cancer type 1 susceptibility protein	LIG_APCC_ABBAyCdc20_2	175:181	KTSVYIE	APC,CDC20,FZR1	0.8923	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons