DegronMD

Uniprot ID: P38398

Source protein: Breast cancer type 1 susceptibility protein

Source gene: BRCA1

Class: DEG_SCF_FBW7_1

Location: 205:212

E3 ligase: FBXW7

DEGRON score: 0.9997

ASA_SCORE: 76.8

COIL: 0.7619

CONS_SCORE: 0.3795

DSS_SCORE: 0.4696

HELIX: 0.162

FCONS_SCORE: 1.0553

RIG_SCORE: 0.7671

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T212A	TCGA-B5-A3FC	UCEC	TCGA	LQITPQGT	DEG_SCF_FBW7_1	0.7139
p.T212A	DO41871	UCEC	ICGC	LQITPQGT	DEG_SCF_FBW7_1	0.7139
p.R213S	TCGA-EE-A3AH	SKCM	TCGA	LQITPQGT	DEG_SCF_FBW7_1	0.3056
p.R213S	DO37443	SKCM	ICGC	LQITPQGT	DEG_SCF_FBW7_1	0.3056
p.P209H	TCGA-ER-A19B	SKCM	TCGA	LQITPQGT	DEG_SCF_FBW7_1	0.7694
p.P209H	DO47491	SKCM	ICGC	LQITPQGT	DEG_SCF_FBW7_1	0.7694
p.T195N	DO228948	LICA	ICGC	LQITPQGT	DEG_SCF_FBW7_1	0.0556
p.G200R	DO224566	LUSC	ICGC	LQITPQGT	DEG_SCF_FBW7_1	0.1944
p.G200R	DO231007	LUSC	ICGC	LQITPQGT	DEG_SCF_FBW7_1	0.1944
p.G211K	DO222843	MELA	ICGC	LQITPQGT	DEG_SCF_FBW7_1	0.6442
p.L222V	DO50291	SKCM	ICGC	LQITPQGT	DEG_SCF_FBW7_1	0.1667
p.L199V	SF126	central_nervous_system	COSMIC	LQITPQGT	DEG_SCF_FBW7_1	0.1667
p.K202R	HT-115	large_intestine	COSMIC	LQITPQGT	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P38398	Breast cancer type 1 susceptibility protein	DEG_SCF_FBW7_1	205:212	LQITPQGT	FBXW7	0.9997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons