DegronMD

Uniprot ID: P38398

Source protein: Breast cancer type 1 susceptibility protein

Source gene: BRCA1

Class: LIG_APCC_ABBA_1

Location: 1568:1573

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9967

ASA_SCORE: 77.3167

COIL: 0.7968

CONS_SCORE: 0.3651

DSS_SCORE: 0.7062

HELIX: 0.0748

FCONS_SCORE: 0.9912

RIG_SCORE: 0.677

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1569M	TCGA-55-6972	LUAD	TCGA	ISLFSD	LIG_APCC_ABBA_1	0.7423
p.T1569M	TCGA-AJ-A3BH	UCEC	TCGA	ISLFSD	LIG_APCC_ABBA_1	0.7423
p.T1569M	SIDM00145	T-Lymphoblastic Leukemia	GDSC	ISLFSD	LIG_APCC_ABBA_1	0.7423
p.T1569M	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	ISLFSD	LIG_APCC_ABBA_1	0.7423
p.T1582A	TCGA-FI-A2D5	UCEC	TCGA	ISLFSD	LIG_APCC_ABBA_1	0.0833
p.D1567N	SIDM01057	Acute Myeloid Leukemia	GDSC	ISLFSD	LIG_APCC_ABBA_1	0.3056
p.D1567N	GDM-1	haematopoietic_and_lymphoid_tissue	COSMIC	ISLFSD	LIG_APCC_ABBA_1	0.3056
p.T1582I	SIDM00254	Neuroblastoma	GDSC	ISLFSD	LIG_APCC_ABBA_1	0.0833
p.S1577P	ACH-000356	Gastric Cancer	CCLE	ISLFSD	LIG_APCC_ABBA_1	0.6667
p.S1577P	ACH-000928	Endometrial/Uterine Cancer	CCLE	ISLFSD	LIG_APCC_ABBA_1	0.6667
p.S1577P	ACH-001549	Lung Cancer	CCLE	ISLFSD	LIG_APCC_ABBA_1	0.6667
p.S1577P	LU-135	lung	COSMIC	ISLFSD	LIG_APCC_ABBA_1	0.6667
p.S1577P	MKN45	stomach	COSMIC	ISLFSD	LIG_APCC_ABBA_1	0.6667
p.P1579S	ACH-000969	Colon/Colorectal Cancer	CCLE	ISLFSD	LIG_APCC_ABBA_1	0.1667
p.P1579S	KM12	large_intestine	COSMIC	ISLFSD	LIG_APCC_ABBA_1	0.1667
p.E1582V	NCI-H2066	lung	COSMIC	ISLFSD	LIG_APCC_ABBA_1	0.0833
p.M1581I	NB7	autonomic_ganglia	COSMIC	ISLFSD	LIG_APCC_ABBA_1	0.1111
p.A1576V	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	ISLFSD	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P38398	Breast cancer type 1 susceptibility protein	LIG_APCC_ABBA_1	1568:1573	ISLFSD	APC,CDC20,FZR1	0.9967	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons