DegronMD

Uniprot ID: Q12872

Source protein: Splicing factor, suppressor of white-apricot homolog

Source gene: SFSWAP

Class: CBL_PTK

Location: 388:397

E3 ligase: CBL

DEGRON score: 0.7558

ASA_SCORE: 78.7

COIL: 0.8637

CONS_SCORE: 0.3351

DSS_SCORE: 0.3123

HELIX: 0.0399

FCONS_SCORE: 0.8815

RIG_SCORE: 0.822

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A381V	TCGA-A5-A0G2	UCEC	TCGA	DVTTYYSTLP	CBL_PTK	0.1389
p.A381V	TCGA-AP-A051	UCEC	TCGA	DVTTYYSTLP	CBL_PTK	0.1389
p.A381V	DO227987	COCA	ICGC	DVTTYYSTLP	CBL_PTK	0.1389
p.A381V	DO41235	UCEC	ICGC	DVTTYYSTLP	CBL_PTK	0.1389
p.A381V	DO42673	UCEC	ICGC	DVTTYYSTLP	CBL_PTK	0.1389
p.A381V	SIDM00217	Colorectal Carcinoma	GDSC	DVTTYYSTLP	CBL_PTK	0.1389
p.A381V	ACH-000999	Colon/Colorectal Cancer	CCLE	DVTTYYSTLP	CBL_PTK	0.1389
p.A381V	SNU-1040	large_intestine	COSMIC	DVTTYYSTLP	CBL_PTK	0.1389
p.P382S	TCGA-DI-A1BU	UCEC	TCGA	DVTTYYSTLP	CBL_PTK	0.1667
p.P382S	DO42023	UCEC	ICGC	DVTTYYSTLP	CBL_PTK	0.1667
p.P384S	TCGA-ER-A195	SKCM	TCGA	DVTTYYSTLP	CBL_PTK	0.2222
p.P384S	DO47712	SKCM	ICGC	DVTTYYSTLP	CBL_PTK	0.2222
p.G386E	TCGA-EW-A1J5	BRCA	TCGA	DVTTYYSTLP	CBL_PTK	0.2778
p.G386E	DO6144	BRCA	ICGC	DVTTYYSTLP	CBL_PTK	0.2778
p.G386V	TCGA-IF-A4AK	SARC	TCGA	DVTTYYSTLP	CBL_PTK	0.2778
p.G386V	DO220165	SARC	ICGC	DVTTYYSTLP	CBL_PTK	0.2778
p.T395S	TCGA-QQ-A8VF	SARC	TCGA	DVTTYYSTLP	CBL_PTK	0.6005
p.T395S	DO220258	SARC	ICGC	DVTTYYSTLP	CBL_PTK	0.6005
p.V389M	TCGA-VQ-AA64	STAD	TCGA	DVTTYYSTLP	CBL_PTK	0.6097
p.V389M	DO222381	STAD	ICGC	DVTTYYSTLP	CBL_PTK	0.6097
p.V400L	DO228948	LICA	ICGC	DVTTYYSTLP	CBL_PTK	0.25
p.G399V	DO228948	LICA	ICGC	DVTTYYSTLP	CBL_PTK	0.2778
p.S394N	DO232224	PBCA	ICGC	DVTTYYSTLP	CBL_PTK	0.7069
p.I387V	SIDM01103	Squamous Cell Lung Carcinoma	GDSC	DVTTYYSTLP	CBL_PTK	0.3056
p.I387V	ACH-000665	Lung Cancer	CCLE	DVTTYYSTLP	CBL_PTK	0.3056
p.I387V	SK-MES-1	lung	COSMIC	DVTTYYSTLP	CBL_PTK	0.3056
p.S405F	SIDM00351	Oral Cavity Carcinoma	GDSC	DVTTYYSTLP	CBL_PTK	0.1111
p.S405F	ACH-002029	Head and Neck Cancer	CCLE	DVTTYYSTLP	CBL_PTK	0.1111
p.S405F	SAS	upper_aerodigestive_tract	COSMIC	DVTTYYSTLP	CBL_PTK	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12872	Splicing factor, suppressor of white-apricot homolog	CBL_PTK	388:397	DVTTYYSTLP	CBL	0.7558	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DVTTYYSTLP

Degron related mutations and impact score

Drug responses associated with SFSWAP mutations

All proteins holding degron of DVTTYYSTLP