DegronMD

Uniprot ID: Q12872

Source protein: Splicing factor, suppressor of white-apricot homolog

Source gene: SFSWAP

Class: DEG_COP1_1

Location: 821:828

E3 ligase: COP1

DEGRON score: 0.7052

ASA_SCORE: 109.3

COIL: 0.811

CONS_SCORE: 0.3037

DSS_SCORE: 0.6923

HELIX: 0.1916

FCONS_SCORE: 0.8003

RIG_SCORE: 0.6189

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C816Y	DO233207	GACA	ICGC	EERSVPTA	DEG_COP1_1	0.1944
p.A837V	DO232846	NACA	ICGC	EERSVPTA	DEG_COP1_1	0.0833
p.R812C	DO47841	STAD	ICGC	EERSVPTA	DEG_COP1_1	0.0833
p.R833C	DO41020	UCEC	ICGC	EERSVPTA	DEG_COP1_1	0.1944
p.A820V	DO42673	UCEC	ICGC	EERSVPTA	DEG_COP1_1	0.3056
p.R830H	ACH-000491	Colon/Colorectal Cancer	CCLE	EERSVPTA	DEG_COP1_1	0.2778
p.R830C	ACH-000990	Endometrial/Uterine Cancer	CCLE	EERSVPTA	DEG_COP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12872	Splicing factor, suppressor of white-apricot homolog	DEG_COP1_1	821:828	EERSVPTA	COP1	0.7052	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons