DegronMD

Uniprot ID: Q8WZ42

Source protein: Titin

Source gene: TTN

Class: DEG_COP1_1

Location: 10180:10191

E3 ligase: COP1

DEGRON score: 0.6047

ASA_SCORE: 91.4667

COIL: 0.8468

CONS_SCORE: 0.3341

DSS_SCORE: 0.3733

HELIX: 0.0702

FCONS_SCORE: 0.9832

RIG_SCORE: 0.7905

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P10197T	TCGA-43-8118	LUSC	TCGA	TEEEVSVTVPEV	DEG_COP1_1	0.1667
p.R10194S	TCGA-55-8203	LUAD	TCGA	TEEEVSVTVPEV	DEG_COP1_1	0.25
p.A10195P	TCGA-A3-3308	KIRC	TCGA	TEEEVSVTVPEV	DEG_COP1_1	0.2222
p.P10179H	TCGA-AM-5821	COAD	TCGA	TEEEVSVTVPEV	DEG_COP1_1	0.3056
p.S10184Y	TCGA-BB-7870	HNSC	TCGA	TEEEVSVTVPEV	DEG_COP1_1	0.712
p.P10189S	TCGA-BF-AAP4	SKCM	TCGA	TEEEVSVTVPEV	DEG_COP1_1	0.6752
p.P10189S	DO228280	LICA	ICGC	TEEEVSVTVPEV	DEG_COP1_1	0.6752
p.E10199K	TCGA-EB-A5FP	SKCM	TCGA	TEEEVSVTVPEV	DEG_COP1_1	0.1111
p.E10199K	TCGA-EE-A29L	SKCM	TCGA	TEEEVSVTVPEV	DEG_COP1_1	0.1111
p.E10190V	DO2020	BRCA	ICGC	TEEEVSVTVPEV	DEG_COP1_1	0.7693
p.E10183K	DO5465	BRCA	ICGC	TEEEVSVTVPEV	DEG_COP1_1	0.591
p.E10183K	DO37715	SKCM	ICGC	TEEEVSVTVPEV	DEG_COP1_1	0.591
p.E10171D	DO225448	GACA	ICGC	TEEEVSVTVPEV	DEG_COP1_1	0.0833
p.F10175L	DO10880	GBM	ICGC	TEEEVSVTVPEV	DEG_COP1_1	0.1944
p.F10175L	DO229036	LICA	ICGC	TEEEVSVTVPEV	DEG_COP1_1	0.1944
p.F10175L	DO40884	UCEC	ICGC	TEEEVSVTVPEV	DEG_COP1_1	0.1944
p.F10175L	DO43186	UCEC	ICGC	TEEEVSVTVPEV	DEG_COP1_1	0.1944
p.F10175L	DO41758	UCEC	ICGC	TEEEVSVTVPEV	DEG_COP1_1	0.1944
p.F10175L	HCC2998	large_intestine	COSMIC	TEEEVSVTVPEV	DEG_COP1_1	0.1944
p.E10194K	DO219879	SKCA	ICGC	TEEEVSVTVPEV	DEG_COP1_1	0.25
p.E10194K	DO37452	SKCM	ICGC	TEEEVSVTVPEV	DEG_COP1_1	0.25
p.E10194K	DO37430	SKCM	ICGC	TEEEVSVTVPEV	DEG_COP1_1	0.25
p.E10194K	DO51276	SKCM	ICGC	TEEEVSVTVPEV	DEG_COP1_1	0.25
p.E10171K	DO219878	SKCA	ICGC	TEEEVSVTVPEV	DEG_COP1_1	0.0833
p.P10189L	DO37782	SKCM	ICGC	TEEEVSVTVPEV	DEG_COP1_1	0.7582
p.K10200N	DO43041	UCEC	ICGC	TEEEVSVTVPEV	DEG_COP1_1	0.1944
p.I10172S	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	TEEEVSVTVPEV	DEG_COP1_1	0.1111
p.I10172S	TE-1	oesophagus	COSMIC	TEEEVSVTVPEV	DEG_COP1_1	0.1111
p.P10198A	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	TEEEVSVTVPEV	DEG_COP1_1	0.1389
p.P10198A	ACH-000929	Lung Cancer	CCLE	TEEEVSVTVPEV	DEG_COP1_1	0.1389
p.P10198A	NCI-H2110	lung	COSMIC	TEEEVSVTVPEV	DEG_COP1_1	0.1389
p.D10180H	SIDM00146	Breast Carcinoma	GDSC	TEEEVSVTVPEV	DEG_COP1_1	0.7688
p.D10180H	MDA-MB-231	breast	COSMIC	TEEEVSVTVPEV	DEG_COP1_1	0.7688
p.E10172G	ACH-001091	Colon/Colorectal Cancer	CCLE	TEEEVSVTVPEV	DEG_COP1_1	0.1111
p.E10175K	ACH-001521	Skin Cancer	CCLE	TEEEVSVTVPEV	DEG_COP1_1	0.1944
p.G10197D	SNU-1040	large_intestine	COSMIC	TEEEVSVTVPEV	DEG_COP1_1	0.1667
p.I10198T	TUR	haematopoietic_and_lymphoid_tissue	COSMIC	TEEEVSVTVPEV	DEG_COP1_1	0.1389
p.A10194V	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	TEEEVSVTVPEV	DEG_COP1_1	0.25
p.V10196A	DAN-G	pancreas	COSMIC	TEEEVSVTVPEV	DEG_COP1_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TEEEVSVTVPEV

Degron related mutations and impact score

Drug responses associated with TTN mutations

All proteins holding degron of TEEEVSVTVPEV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WZ42	Titin	DEG_COP1_1	10180:10191	TEEEVSVTVPEV	COP1	0.6047	More...