DegronMD

Uniprot ID: Q8WZ42

Source protein: Titin

Source gene: TTN

Class: DEG_APCC_DBOX_1

Location: 26227:26235

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7083

ASA_SCORE: 61.8

COIL: 0.2941

CONS_SCORE: 0.5118

DSS_SCORE: 0.4697

HELIX: 0.0117

FCONS_SCORE: 1.0024

RIG_SCORE: 0.8061

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A26238P	TCGA-2F-A9KR	BLCA	TCGA	GRVTLVDVT	DEG_APCC_DBOX_1	0.25
p.C26240F	TCGA-44-6779	LUAD	TCGA	GRVTLVDVT	DEG_APCC_DBOX_1	0.1944
p.P26221S	TCGA-AA-3510	COAD	TCGA	GRVTLVDVT	DEG_APCC_DBOX_1	0.1667
p.E26233K	TCGA-DA-A1HV	SKCM	TCGA	GRVTLVDVT	DEG_APCC_DBOX_1	0.7022
p.G26230V	TCGA-EB-A5UN	SKCM	TCGA	GRVTLVDVT	DEG_APCC_DBOX_1	0.7532
p.N26244S	TCGA-NC-A5HR	LUSC	TCGA	GRVTLVDVT	DEG_APCC_DBOX_1	0.0833
p.L26224I	DO227987	COCA	ICGC	GRVTLVDVT	DEG_APCC_DBOX_1	0.25
p.L26224I	DO42608	UCEC	ICGC	GRVTLVDVT	DEG_APCC_DBOX_1	0.25
p.L26231F	DO222884	COCA	ICGC	GRVTLVDVT	DEG_APCC_DBOX_1	0.6981
p.R26236H	DO234358	ESAD	ICGC	GRVTLVDVT	DEG_APCC_DBOX_1	0.3056
p.S26220C	DO15878	HNSC	ICGC	GRVTLVDVT	DEG_APCC_DBOX_1	0.1389
p.P26223H	DO14774	HNSC	ICGC	GRVTLVDVT	DEG_APCC_DBOX_1	0.2222
p.P26223S	DO14173	HNSC	ICGC	GRVTLVDVT	DEG_APCC_DBOX_1	0.2222
p.V26219L	DO16459	KIRC	ICGC	GRVTLVDVT	DEG_APCC_DBOX_1	0.1111
p.T26238K	DO229034	LICA	ICGC	GRVTLVDVT	DEG_APCC_DBOX_1	0.25
p.T26230I	DO50970	LICA	ICGC	GRVTLVDVT	DEG_APCC_DBOX_1	0.5966
p.T26230P	DO50944	LICA	ICGC	GRVTLVDVT	DEG_APCC_DBOX_1	0.5919
p.E26221Q	DO26769	LUSC	ICGC	GRVTLVDVT	DEG_APCC_DBOX_1	0.1667
p.P26225L	DO229456	SKCA	ICGC	GRVTLVDVT	DEG_APCC_DBOX_1	0.2778
p.V26217I	DO48016	STAD	ICGC	GRVTLVDVT	DEG_APCC_DBOX_1	0.0556
p.V26217I	NCI-H1048	lung	COSMIC	GRVTLVDVT	DEG_APCC_DBOX_1	0.0556
p.V26217I	NCI-H748	lung	COSMIC	GRVTLVDVT	DEG_APCC_DBOX_1	0.0556
p.T26238A	DO42256	UCEC	ICGC	GRVTLVDVT	DEG_APCC_DBOX_1	0.25
p.N26244K	SIDM00530	Esophageal Carcinoma	GDSC	GRVTLVDVT	DEG_APCC_DBOX_1	0.0833
p.N26244K	ACH-001544	Esophageal Cancer	CCLE	GRVTLVDVT	DEG_APCC_DBOX_1	0.0833
p.N26244K	KYAE-1	oesophagus	COSMIC	GRVTLVDVT	DEG_APCC_DBOX_1	0.0833
p.E26236Q	ACH-001960	Bile Duct Cancer	CCLE	GRVTLVDVT	DEG_APCC_DBOX_1	0.3056
p.K26218E	SNU-C2B	large_intestine	COSMIC	GRVTLVDVT	DEG_APCC_DBOX_1	0.1944
p.A26227V	LS-411N	large_intestine	COSMIC	GRVTLVDVT	DEG_APCC_DBOX_1	0.6936
p.E26243Q	NCI-H835	lung	COSMIC	GRVTLVDVT	DEG_APCC_DBOX_1	0.1111
p.R26234C	TGBC1TKB	biliary_tract	COSMIC	GRVTLVDVT	DEG_APCC_DBOX_1	0.8301
p.A26234T	LoVo	large_intestine	COSMIC	GRVTLVDVT	DEG_APCC_DBOX_1	0.7139
p.E26245K	KYSE-510	oesophagus	COSMIC	GRVTLVDVT	DEG_APCC_DBOX_1	0.1667
p.T26240A	EN	endometrium	COSMIC	GRVTLVDVT	DEG_APCC_DBOX_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GRVTLVDVT

Degron related mutations and impact score

Drug responses associated with TTN mutations

All proteins holding degron of GRVTLVDVT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WZ42	Titin	DEG_APCC_DBOX_1	26227:26235	GRVTLVDVT	APC,CDC20,FZR1	0.7083	More...