DegronMD

Uniprot ID: Q8WZ42

Source protein: Titin

Source gene: TTN

Class: DEG_SCF_FBW7_1

Location: 18192:18199

E3 ligase: FBXW7

DEGRON score: 0.5713

ASA_SCORE: 43.0375

COIL: 0.4175

CONS_SCORE: 0.5182

DSS_SCORE: 0.4226

HELIX: 0.0094

FCONS_SCORE: 0.9167

RIG_SCORE: 0.792

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S18196P	TCGA-18-3416	LUSC	TCGA	IDVTPVGS	DEG_SCF_FBW7_1	0.6752
p.I18198V	TCGA-AA-3715	COAD	TCGA	IDVTPVGS	DEG_SCF_FBW7_1	0.7076
p.S18182A	TCGA-AX-A06F	UCEC	TCGA	IDVTPVGS	DEG_SCF_FBW7_1	0.0556
p.E18204D	TCGA-BS-A0UF	UCEC	TCGA	IDVTPVGS	DEG_SCF_FBW7_1	0.1944
p.G18209V	TCGA-D3-A8GQ	SKCM	TCGA	IDVTPVGS	DEG_SCF_FBW7_1	0.0556
p.P18197S	TCGA-FR-A726	SKCM	TCGA	IDVTPVGS	DEG_SCF_FBW7_1	0.6752
p.R18204S	DO223588	BLCA	ICGC	IDVTPVGS	DEG_SCF_FBW7_1	0.1944
p.N18205T	DO10955	GBM	ICGC	IDVTPVGS	DEG_SCF_FBW7_1	0.1667
p.A18190E	DO229029	LICA	ICGC	IDVTPVGS	DEG_SCF_FBW7_1	0.2778
p.E18209K	DO23759	LUAD	ICGC	IDVTPVGS	DEG_SCF_FBW7_1	0.0556
p.P18196S	DO28119	OV	ICGC	IDVTPVGS	DEG_SCF_FBW7_1	0.6752
p.R18204C	DO228168	PBCA	ICGC	IDVTPVGS	DEG_SCF_FBW7_1	0.1944
p.R18204C	MCC13	skin	COSMIC	IDVTPVGS	DEG_SCF_FBW7_1	0.1944
p.R18191K	DO38051	SKCM	ICGC	IDVTPVGS	DEG_SCF_FBW7_1	0.3056
p.I18192T	DO223907	SKCM	ICGC	IDVTPVGS	DEG_SCF_FBW7_1	0.7078
p.S18199N	DO40889	UCEC	ICGC	IDVTPVGS	DEG_SCF_FBW7_1	0.7069
p.A18207V	DO41752	UCEC	ICGC	IDVTPVGS	DEG_SCF_FBW7_1	0.1111
p.V18185M	SIDM00921	Non-Small Cell Lung Carcinoma	GDSC	IDVTPVGS	DEG_SCF_FBW7_1	0.1389
p.V18185M	ACH-000264	Lung Cancer	CCLE	IDVTPVGS	DEG_SCF_FBW7_1	0.1389
p.V18185M	Calu-6	lung	COSMIC	IDVTPVGS	DEG_SCF_FBW7_1	0.1389
p.S18196A	SIDM01347	Ovarian Carcinoma	GDSC	IDVTPVGS	DEG_SCF_FBW7_1	0.7588
p.S18196A	ACH-000701	Ovarian Cancer	CCLE	IDVTPVGS	DEG_SCF_FBW7_1	0.7588
p.K18191T	SNU-81	large_intestine	COSMIC	IDVTPVGS	DEG_SCF_FBW7_1	0.3056
p.P18185S	Sarc9371	bone	COSMIC	IDVTPVGS	DEG_SCF_FBW7_1	0.1389
p.A18209V	HCT-116	large_intestine	COSMIC	IDVTPVGS	DEG_SCF_FBW7_1	0.0556
p.I18192L	RCC10RGB	kidney	COSMIC	IDVTPVGS	DEG_SCF_FBW7_1	0.6063
p.I18205T	PE/CA-PJ15	upper_aerodigestive_tract	COSMIC	IDVTPVGS	DEG_SCF_FBW7_1	0.1667
p.P18185L	Sarc9371	bone	COSMIC	IDVTPVGS	DEG_SCF_FBW7_1	0.1389
p.P18203L	NCI-H630	large_intestine	COSMIC	IDVTPVGS	DEG_SCF_FBW7_1	0.2222
p.P18196Q	RT4	urinary_tract	COSMIC	IDVTPVGS	DEG_SCF_FBW7_1	0.7035
p.V18187A	SKN	soft_tissue	COSMIC	IDVTPVGS	DEG_SCF_FBW7_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IDVTPVGS

Degron related mutations and impact score

Drug responses associated with TTN mutations

All proteins holding degron of IDVTPVGS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WZ42	Titin	DEG_SCF_FBW7_1	18192:18199	IDVTPVGS	FBXW7	0.5713	More...