DegronMD

Uniprot ID: Q8WZ42

Source protein: Titin

Source gene: TTN

Class: DEG_SCF_FBW7_1

Location: 18192:18199

E3 ligase: FBXW7

DEGRON score: 0.5713

ASA_SCORE: 43.0375

COIL: 0.4175

CONS_SCORE: 0.5182

DSS_SCORE: 0.4226

HELIX: 0.0094

FCONS_SCORE: 0.9167

RIG_SCORE: 0.792

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S18196A	SIDM01347	Ovarian Carcinoma	GDSC	IDVTPVGS	DEG_SCF_FBW7_1	0.7588
p.S18196A	ACH-000701	Ovarian Cancer	CCLE	IDVTPVGS	DEG_SCF_FBW7_1	0.7588
p.I18192T	DO223907	SKCM	ICGC	IDVTPVGS	DEG_SCF_FBW7_1	0.7078
p.I18198V	TCGA-AA-3715	COAD	TCGA	IDVTPVGS	DEG_SCF_FBW7_1	0.7076
p.S18199N	DO40889	UCEC	ICGC	IDVTPVGS	DEG_SCF_FBW7_1	0.7069
p.P18196Q	RT4	urinary_tract	COSMIC	IDVTPVGS	DEG_SCF_FBW7_1	0.7035
p.S18196P	TCGA-18-3416	LUSC	TCGA	IDVTPVGS	DEG_SCF_FBW7_1	0.6752
p.P18197S	TCGA-FR-A726	SKCM	TCGA	IDVTPVGS	DEG_SCF_FBW7_1	0.6752
p.P18196S	DO28119	OV	ICGC	IDVTPVGS	DEG_SCF_FBW7_1	0.6752
p.I18192L	RCC10RGB	kidney	COSMIC	IDVTPVGS	DEG_SCF_FBW7_1	0.6063
p.R18191K	DO38051	SKCM	ICGC	IDVTPVGS	DEG_SCF_FBW7_1	0.3056
p.K18191T	SNU-81	large_intestine	COSMIC	IDVTPVGS	DEG_SCF_FBW7_1	0.3056
p.A18190E	DO229029	LICA	ICGC	IDVTPVGS	DEG_SCF_FBW7_1	0.2778
p.P18203L	NCI-H630	large_intestine	COSMIC	IDVTPVGS	DEG_SCF_FBW7_1	0.2222
p.E18204D	TCGA-BS-A0UF	UCEC	TCGA	IDVTPVGS	DEG_SCF_FBW7_1	0.1944
p.R18204S	DO223588	BLCA	ICGC	IDVTPVGS	DEG_SCF_FBW7_1	0.1944
p.R18204C	DO228168	PBCA	ICGC	IDVTPVGS	DEG_SCF_FBW7_1	0.1944
p.R18204C	MCC13	skin	COSMIC	IDVTPVGS	DEG_SCF_FBW7_1	0.1944
p.V18187A	SKN	soft_tissue	COSMIC	IDVTPVGS	DEG_SCF_FBW7_1	0.1944
p.N18205T	DO10955	GBM	ICGC	IDVTPVGS	DEG_SCF_FBW7_1	0.1667
p.I18205T	PE/CA-PJ15	upper_aerodigestive_tract	COSMIC	IDVTPVGS	DEG_SCF_FBW7_1	0.1667
p.V18185M	SIDM00921	Non-Small Cell Lung Carcinoma	GDSC	IDVTPVGS	DEG_SCF_FBW7_1	0.1389
p.V18185M	ACH-000264	Lung Cancer	CCLE	IDVTPVGS	DEG_SCF_FBW7_1	0.1389
p.V18185M	Calu-6	lung	COSMIC	IDVTPVGS	DEG_SCF_FBW7_1	0.1389
p.P18185S	Sarc9371	bone	COSMIC	IDVTPVGS	DEG_SCF_FBW7_1	0.1389

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Drug responses associated with TTN mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of IDVTPVGS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WZ42	Titin	DEG_SCF_FBW7_1	18192:18199	IDVTPVGS	FBXW7	0.5713	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IDVTPVGS

Degron related mutations and impact score

Drug responses associated with TTN mutations

All proteins holding degron of IDVTPVGS