DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PPLY
Uniprot ID:
Q8WZ42
Source protein:
Titin
Source gene:
TTN
Class:
ITCH
Location:
24273:24276
E3 ligase:
ITCH,NEDD4
DEGRON score:
0.6137
ASA_SCORE:
76.4
COIL:
0.8893
CONS_SCORE:
0.5879
DSS_SCORE:
0.2305
HELIX:
0.0795
FCONS_SCORE:
1.0021
RIG_SCORE:
0.8054
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P24273H
DO42673
UCEC
ICGC
PPLY
ITCH
0.7694
p.Y24276H
DO24275
LUAD
ICGC
PPLY
ITCH
0.7229
p.P24273T
DO228974
LICA
ICGC
PPLY
ITCH
0.7031
p.S24285Y
TCGA-AX-A06F
UCEC
TCGA
PPLY
ITCH
0.5278
p.Y24285H
DO45153
LIRI
ICGC
PPLY
ITCH
0.5278
p.G24278E
DO229050
LICA
ICGC
PPLY
ITCH
0.2778
p.G24279D
DO48654
SKCM
ICGC
PPLY
ITCH
0.25
p.A24270S
NCI-H23
lung
COSMIC
PPLY
ITCH
0.25
p.M24279T
ASH-3
thyroid
COSMIC
PPLY
ITCH
0.25
p.I24269T
ZR-75-30
breast
COSMIC
PPLY
ITCH
0.2222
p.R24268C
TCGA-59-2349
OV
TCGA
PPLY
ITCH
0.1944
p.R24268H
SIDM00234
Other Solid Cancers
GDSC
PPLY
ITCH
0.1944
p.R24268H
SIDM00463
T-Lymphoblastic Leukemia
GDSC
PPLY
ITCH
0.1944
p.R24268H
SIDM00235
Kidney Carcinoma
GDSC
PPLY
ITCH
0.1944
p.R24268H
SIDM00596
Endometrial Carcinoma
GDSC
PPLY
ITCH
0.1944
p.R24268H
SIDM00365
Small Cell Lung Carcinoma
GDSC
PPLY
ITCH
0.1944
p.R24268H
SIDM01217
Other Blood Cancers
GDSC
PPLY
ITCH
0.1944
p.R24268H
SIDM01257
Hepatocellular Carcinoma
GDSC
PPLY
ITCH
0.1944
p.R24268H
SIDM01612
Endometrial Carcinoma
GDSC
PPLY
ITCH
0.1944
p.R24268H
SIDM01470
Acute Myeloid Leukemia
GDSC
PPLY
ITCH
0.1944
p.R24268H
SIDM00062
Hepatocellular Carcinoma
GDSC
PPLY
ITCH
0.1944
p.R24268H
SIDM01764
Non-Small Cell Lung Carcinoma
GDSC
PPLY
ITCH
0.1944
p.R24268H
MY-M12
haematopoietic_and_lymphoid_tissue
COSMIC
PPLY
ITCH
0.1944
p.R24268H
HUH-6-clone5
liver
COSMIC
PPLY
ITCH
0.1944
p.R24268H
P12-ICHIKAWA
haematopoietic_and_lymphoid_tissue
COSMIC
PPLY
ITCH
0.1944
Showing 1 to 25 of 34 entries
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Drug responses associated with TTN mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of PPLY
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P82914
28S ribosomal protein S15, mitochondrial
ITCH
192:195
PPLY
ITCH,NEDD4
0.8188
More...
Q6DCA0
AMMECR1-like protein
ITCH
303:306
PPLY
ITCH,NEDD4
0.9894
More...
Q86XL3
Ankyrin repeat and LEM domain-containing protein 2
ITCH
196:199
PPLY
ITCH,NEDD4
0.9937
More...
Q8TBH0
Arrestin domain-containing protein 2
ITCH
385:388
PPLY
ITCH,NEDD4
0.9798
More...
Q96B67
Arrestin domain-containing protein 3
ITCH
391:394
PPLY
ITCH,NEDD4
0.9963
More...
Q8NCT1
Arrestin domain-containing protein 4
ITCH
395:398
PPLY
ITCH,NEDD4
0.8354
More...
O95429
BAG family molecular chaperone regulator 4
ITCH
34:37
PPLY
ITCH,NEDD4
0.9898
More...
Q9BXF3
Cat eye syndrome critical region protein 2
ITCH
1137:1140
PPLY
ITCH,NEDD4
0.8075
More...
Q9P209
Centrosomal protein of 72 kDa
ITCH
278:281
PPLY
ITCH,NEDD4
0.7298
More...
Q8NCG7
Diacylglycerol lipase-beta
ITCH
588:591
PPLY
ITCH,NEDD4
0.838
More...
Q13443
Disintegrin and metalloproteinase domain-containing protein 9
ITCH
812:815
PPLY
ITCH,NEDD4
0.9977
More...
Q8TDM6
Disks large homolog 5
ITCH
1166:1169
PPLY
ITCH,NEDD4
0.9662
More...
P54098
DNA polymerase subunit gamma-1
ITCH
128:131
PPLY
ITCH,NEDD4
0.9114
More...
Q7Z6E9
E3 ubiquitin-protein ligase RBBP6
ITCH
562:565
PPLY
ITCH,NEDD4
0.9715
More...
P62508
Estrogen-related receptor gamma
ITCH
82:85
PPLY
ITCH,NEDD4
0.9981
More...
Q99958
Forkhead box protein C2
ITCH
485:488
PPLY
ITCH,NEDD4
0.9946
More...
Q9P0K8
Forkhead box protein J2
ITCH
230:233
PPLY
ITCH,NEDD4
0.8417
More...
Q2KHR3
Glutamine and serine-rich protein 1
ITCH
370:373
PPLY
ITCH,NEDD4
0.8458
More...
Q9H0J4
Glutamine-rich protein 2
ITCH
1404:1407
PPLY
ITCH,NEDD4
0.9172
More...
Q96CC6
Inactive rhomboid protein 1
ITCH
141:144
PPLY
ITCH,NEDD4
0.9927
More...
Q8NDH2
Leucine-rich repeat transmembrane protein CCDC168
ITCH
5560:5563
PPLY
ITCH,NEDD4
0.6888
More...
Q9P2G4
Microtubule-associated protein 10
ITCH
302:305
PPLY
ITCH,NEDD4
0.9678
More...
Q9HB07
MYG1 exonuclease
ITCH
17:20
PPLY
ITCH,NEDD4
0.6345
More...
Q02080
Myocyte-specific enhancer factor 2B
ITCH
198:201
PPLY
ITCH,NEDD4
0.992
More...
Q5VTT5
Myomesin-3
ITCH
824:827
PPLY
ITCH,NEDD4
0.901
More...
Showing 1 to 25 of 51 entries
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