DegronMD

Uniprot ID: Q8WZ42

Source protein: Titin

Source gene: TTN

Class: ITCH

Location: 24273:24276

E3 ligase: ITCH,NEDD4

DEGRON score: 0.6137

ASA_SCORE: 76.4

COIL: 0.8893

CONS_SCORE: 0.5879

DSS_SCORE: 0.2305

HELIX: 0.0795

FCONS_SCORE: 1.0021

RIG_SCORE: 0.8054

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R24268C	TCGA-59-2349	OV	TCGA	PPLY	ITCH	0.1944
p.S24285Y	TCGA-AX-A06F	UCEC	TCGA	PPLY	ITCH	0.5278
p.P24273T	DO228974	LICA	ICGC	PPLY	ITCH	0.7031
p.G24278E	DO229050	LICA	ICGC	PPLY	ITCH	0.2778
p.Y24285H	DO45153	LIRI	ICGC	PPLY	ITCH	0.5278
p.Y24276H	DO24275	LUAD	ICGC	PPLY	ITCH	0.7229
p.E24265K	DO26210	LUAD	ICGC	PPLY	ITCH	0.1111
p.G24279D	DO48654	SKCM	ICGC	PPLY	ITCH	0.25
p.P24273H	DO42673	UCEC	ICGC	PPLY	ITCH	0.7694
p.K24264E	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PPLY	ITCH	0.0833
p.K24264E	ACH-000995	Leukemia	CCLE	PPLY	ITCH	0.0833
p.K24264E	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PPLY	ITCH	0.0833
p.R24268H	SIDM00234	Other Solid Cancers	GDSC	PPLY	ITCH	0.1944
p.R24268H	SIDM00463	T-Lymphoblastic Leukemia	GDSC	PPLY	ITCH	0.1944
p.R24268H	SIDM00235	Kidney Carcinoma	GDSC	PPLY	ITCH	0.1944
p.R24268H	SIDM00596	Endometrial Carcinoma	GDSC	PPLY	ITCH	0.1944
p.R24268H	SIDM00365	Small Cell Lung Carcinoma	GDSC	PPLY	ITCH	0.1944
p.R24268H	SIDM01217	Other Blood Cancers	GDSC	PPLY	ITCH	0.1944
p.R24268H	SIDM01257	Hepatocellular Carcinoma	GDSC	PPLY	ITCH	0.1944
p.R24268H	SIDM01612	Endometrial Carcinoma	GDSC	PPLY	ITCH	0.1944
p.R24268H	SIDM01470	Acute Myeloid Leukemia	GDSC	PPLY	ITCH	0.1944
p.R24268H	SIDM00062	Hepatocellular Carcinoma	GDSC	PPLY	ITCH	0.1944
p.R24268H	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	PPLY	ITCH	0.1944
p.R24268H	MY-M12	haematopoietic_and_lymphoid_tissue	COSMIC	PPLY	ITCH	0.1944
p.R24268H	HUH-6-clone5	liver	COSMIC	PPLY	ITCH	0.1944
p.R24268H	P12-ICHIKAWA	haematopoietic_and_lymphoid_tissue	COSMIC	PPLY	ITCH	0.1944
p.A24270S	NCI-H23	lung	COSMIC	PPLY	ITCH	0.25
p.R24284C	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	PPLY	ITCH	0.1111
p.R24284C	HuCCT1	biliary_tract	COSMIC	PPLY	ITCH	0.1111
p.R24281H	TASK1	bone	COSMIC	PPLY	ITCH	0.1944
p.A24268V	C-33-A	cervix	COSMIC	PPLY	ITCH	0.1944
p.V24267A	KATOIII	stomach	COSMIC	PPLY	ITCH	0.1667
p.I24269T	ZR-75-30	breast	COSMIC	PPLY	ITCH	0.2222
p.M24279T	ASH-3	thyroid	COSMIC	PPLY	ITCH	0.25

Drug responses associated with TTN mutations

All proteins holding degron of PPLY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14746	Telomerase reverse transcriptase	ITCH	173:176	PPLY	ITCH,NEDD4	0.9126	More...
O75132	Zinc finger BED domain-containing protein 4	ITCH	349:352	PPLY	ITCH,NEDD4	0.9903	More...
O95429	BAG family molecular chaperone regulator 4	ITCH	34:37	PPLY	ITCH,NEDD4	0.9898	More...
P02774	Vitamin D-binding protein	ITCH	458:461	PPLY	ITCH,NEDD4	0.8999	More...
P20783	Neurotrophin-3	ITCH	115:118	PPLY	ITCH,NEDD4	0.966	More...
P54098	DNA polymerase subunit gamma-1	ITCH	128:131	PPLY	ITCH,NEDD4	0.9114	More...
P62508	Estrogen-related receptor gamma	ITCH	82:85	PPLY	ITCH,NEDD4	0.9981	More...
Q02080	Myocyte-specific enhancer factor 2B	ITCH	198:201	PPLY	ITCH,NEDD4	0.992	More...
Q07890	Son of sevenless homolog 2	ITCH	1317:1320	PPLY	ITCH,NEDD4	0.9994	More...
Q13443	Disintegrin and metalloproteinase domain-containing protein 9	ITCH	812:815	PPLY	ITCH,NEDD4	0.9977	More...
Q13796	Protein Shroom2	ITCH	429:432	PPLY	ITCH,NEDD4	0.9947	More...
Q14934	Nuclear factor of activated T-cells, cytoplasmic 4	ITCH	746:749	PPLY	ITCH,NEDD4	0.9988	More...
Q5VTT5	Myomesin-3	ITCH	824:827	PPLY	ITCH,NEDD4	0.901	More...
Q6NSI4	RPA-related protein RADX	ITCH	90:93	PPLY	ITCH,NEDD4	0.7785	More...
Q7Z6E9	E3 ubiquitin-protein ligase RBBP6	ITCH	562:565	PPLY	ITCH,NEDD4	0.9715	More...
Q86XL3	Ankyrin repeat and LEM domain-containing protein 2	ITCH	196:199	PPLY	ITCH,NEDD4	0.9937	More...
Q8N3G9	Transmembrane protein 130	ITCH	424:427	PPLY	ITCH,NEDD4	0.6297	More...
Q8NCG7	Diacylglycerol lipase-beta	ITCH	588:591	PPLY	ITCH,NEDD4	0.838	More...
Q8NCT1	Arrestin domain-containing protein 4	ITCH	395:398	PPLY	ITCH,NEDD4	0.8354	More...
Q8TDM6	Disks large homolog 5	ITCH	1166:1169	PPLY	ITCH,NEDD4	0.9662	More...
Q8WZ42	Titin	ITCH	15529:15532	PPLY	ITCH,NEDD4	0.8933	More...
Q8WZ42	Titin	ITCH	24273:24276	PPLY	ITCH,NEDD4	0.6137	More...
Q96B67	Arrestin domain-containing protein 3	ITCH	391:394	PPLY	ITCH,NEDD4	0.9963	More...
Q96CC6	Inactive rhomboid protein 1	ITCH	141:144	PPLY	ITCH,NEDD4	0.9927	More...
Q96JG9	Zinc finger protein 469	ITCH	1438:1441	PPLY	ITCH,NEDD4	0.9749	More...
Q99935	Opiorphin prepropeptide	ITCH	37:40	PPLY	ITCH,NEDD4	0.7838	More...
Q99958	Forkhead box protein C2	ITCH	485:488	PPLY	ITCH,NEDD4	0.9946	More...
Q9BXF3	Cat eye syndrome critical region protein 2	ITCH	1137:1140	PPLY	ITCH,NEDD4	0.8075	More...
Q9H0J4	Glutamine-rich protein 2	ITCH	1404:1407	PPLY	ITCH,NEDD4	0.9172	More...
Q9H1C4	Protein unc-93 homolog B1	ITCH	5:8	PPLY	ITCH,NEDD4	0.9981	More...
Q9HB07	MYG1 exonuclease	ITCH	17:20	PPLY	ITCH,NEDD4	0.6345	More...
Q9HCM1	Retroelement silencing factor 1	ITCH	13:16	PPLY	ITCH,NEDD4	0.9921	More...
Q9NYA4	Myotubularin-related protein 4	ITCH	1005:1008	PPLY	ITCH,NEDD4	0.9953	More...
Q9P0K8	Forkhead box protein J2	ITCH	230:233	PPLY	ITCH,NEDD4	0.8417	More...
Q9P209	Centrosomal protein of 72 kDa	ITCH	278:281	PPLY	ITCH,NEDD4	0.7298	More...
Q9P2G4	Microtubule-associated protein 10	ITCH	302:305	PPLY	ITCH,NEDD4	0.9678	More...
P82914	28S ribosomal protein S15, mitochondrial	ITCH	192:195	PPLY	ITCH,NEDD4	0.8188	More...
Q5JSZ5	Protein PRRC2B	ITCH	1924:1927	PPLY	ITCH,NEDD4	0.905	More...
Q8WWH5	Pseudouridylate synthase TRUB1	ITCH	197:200	PPLY	ITCH,NEDD4	0.9721	More...
Q9C0H5	Rho GTPase-activating protein 39	ITCH	310:313	PPLY	ITCH,NEDD4	0.9222	More...
Q2KHR3	Glutamine and serine-rich protein 1	ITCH	370:373	PPLY	ITCH,NEDD4	0.8458	More...
Q6AHZ1	Zinc finger protein 518A	ITCH	1092:1095	PPLY	ITCH,NEDD4	0.9935	More...
Q6ZRI6	Uncharacterized protein C15orf39	ITCH	70:73	PPLY	ITCH,NEDD4	0.981	More...
Q8NDH2	Leucine-rich repeat transmembrane protein CCDC168	ITCH	5560:5563	PPLY	ITCH,NEDD4	0.6888	More...
Q8TBH0	Arrestin domain-containing protein 2	ITCH	385:388	PPLY	ITCH,NEDD4	0.9798	More...
Q9ULL5	Proline-rich protein 12	ITCH	1296:1299	PPLY	ITCH,NEDD4	0.9929	More...
Q3C1V1	Uncharacterized protein C11orf91	ITCH	19:22	PPLY	ITCH,NEDD4	0.9367	More...
Q68EN5	Uncharacterized protein KIAA0895-like	ITCH	36:39	PPLY	ITCH,NEDD4	0.9661	More...
Q6DCA0	AMMECR1-like protein	ITCH	303:306	PPLY	ITCH,NEDD4	0.9894	More...
Q6MZM9	Proline-rich protein 27	ITCH	49:52	PPLY	ITCH,NEDD4	0.5514	More...
Q8N6L7	Transmembrane protein 252	ITCH	123:126	PPLY	ITCH,NEDD4	0.9539	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPLY

Degron related mutations and impact score

Drug responses associated with TTN mutations

All proteins holding degron of PPLY