DegronMD - Q8WWH5(TRUB1)

TRUB1

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D206H	TCGA-BT-A20W	BLCA	TCGA	PPLY	ITCH	197:200	Mutation rewiring degron network	0.1667
p.D206H	DO657	BLCA	ICGC	PPLY	ITCH	197:200	Mutation rewiring degron network	0.1667
p.L210P	TCGA-CG-5721	STAD	TCGA	PPLY	ITCH	197:200	Mutation rewiring degron network	0.0556
p.L210P	DO38192	STAD	ICGC	PPLY	ITCH	197:200	Mutation rewiring degron network	0.0556
p.K188T	DO222884	COCA	ICGC	PPLY	ITCH	197:200	Mutation substituting flanking lysine	0.1944
p.N192K	SIDM00453	Pancreatic Carcinoma	GDSC	PPLY	ITCH	197:200	Mutation rewiring degron network	0.1944
p.N192K	PA-TU-8988T	pancreas	COSMIC	PPLY	ITCH	197:200	Mutation rewiring degron network	0.1944
p.R209I	SIDM00193	Colorectal Carcinoma	GDSC	PPLY	ITCH	197:200	Mutation rewiring degron network	0.0833
p.R209I	ACH-000991	Colon/Colorectal Cancer	CCLE	PPLY	ITCH	197:200	Mutation rewiring degron network	0.0833
p.R209I	SNU-81	large intestine	COSMIC	PPLY	ITCH	197:200	Mutation rewiring degron network	0.0833
p.K204R	SIDM01608	Endometrial Carcinoma	GDSC	PPLY	ITCH	197:200	Mutation blocking ubiquitination signal	0.6667
p.K204R	ACH-000990	Endometrial/Uterine Cancer	CCLE	PPLY	ITCH	197:200	Mutation blocking ubiquitination signal	0.6667

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*NOTE: the Kaplan plots were collected from OncoLnc