DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
PPLY
Uniprot ID:
Q8WWH5
Source protein:
Pseudouridylate synthase TRUB1
Source gene:
TRUB1
Class:
ITCH
Location:
197:200
E3 ligase:
ITCH,NEDD4
DEGRON score:
0.9721
ASA_SCORE:
50.3
COIL:
0.7215
CONS_SCORE:
0.6587
DSS_SCORE:
0.358
HELIX:
0.1723
FCONS_SCORE:
1.1308
RIG_SCORE:
0.8373
Degron related mutations and impact score
Show
10
25
50
100
entries
Search:
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.K204R
SIDM01608
Endometrial Carcinoma
GDSC
PPLY
ITCH
0.6667
p.K204R
ACH-000990
Endometrial/Uterine Cancer
CCLE
PPLY
ITCH
0.6667
p.K188T
DO222884
COCA
ICGC
PPLY
ITCH
0.1944
p.N192K
SIDM00453
Pancreatic Carcinoma
GDSC
PPLY
ITCH
0.1944
p.N192K
PA-TU-8988T
pancreas
COSMIC
PPLY
ITCH
0.1944
p.D206H
TCGA-BT-A20W
BLCA
TCGA
PPLY
ITCH
0.1667
p.D206H
DO657
BLCA
ICGC
PPLY
ITCH
0.1667
p.R209I
SIDM00193
Colorectal Carcinoma
GDSC
PPLY
ITCH
0.0833
p.R209I
ACH-000991
Colon/Colorectal Cancer
CCLE
PPLY
ITCH
0.0833
p.R209I
SNU-81
large_intestine
COSMIC
PPLY
ITCH
0.0833
p.L210P
TCGA-CG-5721
STAD
TCGA
PPLY
ITCH
0.0556
p.L210P
DO38192
STAD
ICGC
PPLY
ITCH
0.0556
Showing 1 to 12 of 12 entries
Previous
1
Next
Drug responses associated with TRUB1 mutations
Show
10
25
50
100
entries
Search:
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
Showing 0 to 0 of 0 entries
Previous
Next
All proteins holding degron of PPLY
Show
10
25
50
100
entries
Search:
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P82914
28S ribosomal protein S15, mitochondrial
ITCH
192:195
PPLY
ITCH,NEDD4
0.8188
More...
Q6DCA0
AMMECR1-like protein
ITCH
303:306
PPLY
ITCH,NEDD4
0.9894
More...
Q86XL3
Ankyrin repeat and LEM domain-containing protein 2
ITCH
196:199
PPLY
ITCH,NEDD4
0.9937
More...
Q8TBH0
Arrestin domain-containing protein 2
ITCH
385:388
PPLY
ITCH,NEDD4
0.9798
More...
Q96B67
Arrestin domain-containing protein 3
ITCH
391:394
PPLY
ITCH,NEDD4
0.9963
More...
Q8NCT1
Arrestin domain-containing protein 4
ITCH
395:398
PPLY
ITCH,NEDD4
0.8354
More...
O95429
BAG family molecular chaperone regulator 4
ITCH
34:37
PPLY
ITCH,NEDD4
0.9898
More...
Q9BXF3
Cat eye syndrome critical region protein 2
ITCH
1137:1140
PPLY
ITCH,NEDD4
0.8075
More...
Q9P209
Centrosomal protein of 72 kDa
ITCH
278:281
PPLY
ITCH,NEDD4
0.7298
More...
Q8NCG7
Diacylglycerol lipase-beta
ITCH
588:591
PPLY
ITCH,NEDD4
0.838
More...
Q13443
Disintegrin and metalloproteinase domain-containing protein 9
ITCH
812:815
PPLY
ITCH,NEDD4
0.9977
More...
Q8TDM6
Disks large homolog 5
ITCH
1166:1169
PPLY
ITCH,NEDD4
0.9662
More...
P54098
DNA polymerase subunit gamma-1
ITCH
128:131
PPLY
ITCH,NEDD4
0.9114
More...
Q7Z6E9
E3 ubiquitin-protein ligase RBBP6
ITCH
562:565
PPLY
ITCH,NEDD4
0.9715
More...
P62508
Estrogen-related receptor gamma
ITCH
82:85
PPLY
ITCH,NEDD4
0.9981
More...
Q99958
Forkhead box protein C2
ITCH
485:488
PPLY
ITCH,NEDD4
0.9946
More...
Q9P0K8
Forkhead box protein J2
ITCH
230:233
PPLY
ITCH,NEDD4
0.8417
More...
Q2KHR3
Glutamine and serine-rich protein 1
ITCH
370:373
PPLY
ITCH,NEDD4
0.8458
More...
Q9H0J4
Glutamine-rich protein 2
ITCH
1404:1407
PPLY
ITCH,NEDD4
0.9172
More...
Q96CC6
Inactive rhomboid protein 1
ITCH
141:144
PPLY
ITCH,NEDD4
0.9927
More...
Q8NDH2
Leucine-rich repeat transmembrane protein CCDC168
ITCH
5560:5563
PPLY
ITCH,NEDD4
0.6888
More...
Q9P2G4
Microtubule-associated protein 10
ITCH
302:305
PPLY
ITCH,NEDD4
0.9678
More...
Q9HB07
MYG1 exonuclease
ITCH
17:20
PPLY
ITCH,NEDD4
0.6345
More...
Q02080
Myocyte-specific enhancer factor 2B
ITCH
198:201
PPLY
ITCH,NEDD4
0.992
More...
Q5VTT5
Myomesin-3
ITCH
824:827
PPLY
ITCH,NEDD4
0.901
More...
Showing 1 to 25 of 51 entries
Previous
1
2
3
Next
