DegronMD - Q9H0J4(QRICH2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E1029Q	TCGA-69-7765	LUAD	TCGA	RRNSLRRMS	DEG_APCC_DBOX_1	1013:1021	Mutation rewiring degron network	0.1111
p.E1029Q	DO23580	LUAD	ICGC	RRNSLRRMS	DEG_APCC_DBOX_1	1013:1021	Mutation rewiring degron network	0.1111
p.R1416W	TCGA-AA-3510	COAD	TCGA	PPLY	ITCH	1404:1407	Mutation rewiring degron network	0.0833
p.R1416W	DO7783	COAD	ICGC	PPLY	ITCH	1404:1407	Mutation rewiring degron network	0.0833
p.R1416W	SIDM00835	Colorectal Carcinoma	GDSC	PPLY	ITCH	1404:1407	Mutation rewiring degron network	0.0833
p.R1416W	SIDM00534	Colorectal Carcinoma	GDSC	PPLY	ITCH	1404:1407	Mutation rewiring degron network	0.0833
p.R1416W	HT-115	large intestine	COSMIC	PPLY	ITCH	1404:1407	Mutation rewiring degron network	0.0833
p.D1484V	TCGA-AB-2899	LAML	TCGA	PRGDLAQME	DEG_APCC_DBOX_1	1481:1489	Mutation altering degron motif	0.6674
p.D1484V	DO21529	LAML	ICGC	PRGDLAQME	DEG_APCC_DBOX_1	1481:1489	Mutation altering degron motif	0.6674
p.R1416Q	TCGA-AJ-A3EK	UCEC	TCGA	PPLY	ITCH	1404:1407	Mutation rewiring degron network	0.0833
p.R1416Q	DO41584	UCEC	ICGC	PPLY	ITCH	1404:1407	Mutation rewiring degron network	0.0833
p.Q1398R	TCGA-AP-A1DK	UCEC	TCGA	PPLY	ITCH	1404:1407	Mutation rewiring degron network	0.1667
p.Q1398R	DO42033	UCEC	ICGC	PPLY	ITCH	1404:1407	Mutation rewiring degron network	0.1667
p.D1543Y	TCGA-AX-A2HD	UCEC	TCGA	DMADYTYSTVP	CBL_PTK	1543:1553	Mutation altering degron motif	0.7325
p.D1543Y	DO42608	UCEC	ICGC	DMADYTYSTVP	CBL_PTK	1543:1553	Mutation altering degron motif	0.7325
p.G1493W	TCGA-D1-A1NZ	UCEC	TCGA	PRGDLAQME	DEG_APCC_DBOX_1	1481:1489	Mutation rewiring degron network	0.2222
p.G1493W	DO41536	UCEC	ICGC	PRGDLAQME	DEG_APCC_DBOX_1	1481:1489	Mutation rewiring degron network	0.2222
p.E1402K	TCGA-D6-6516	HNSC	TCGA	PPLY	ITCH	1404:1407	Mutation rewiring degron network	0.2778
p.E1402K	DO15623	HNSC	ICGC	PPLY	ITCH	1404:1407	Mutation rewiring degron network	0.2778
p.S1535F	TCGA-D9-A6EC	SKCM	TCGA	DMADYTYSTVP	CBL_PTK	1543:1553	Mutation rewiring degron network	0.1111
p.S1535F	DO50291	SKCM	ICGC	DMADYTYSTVP	CBL_PTK	1543:1553	Mutation rewiring degron network	0.1111
p.P1025L	TCGA-EE-A2MN	SKCM	TCGA	RRNSLRRMS	DEG_APCC_DBOX_1	1013:1021	Mutation rewiring degron network	0.2222
p.P1025L	DO222438	MELA	ICGC	RRNSLRRMS	DEG_APCC_DBOX_1	1013:1021	Mutation rewiring degron network	0.2222
p.P1025L	DO37423	SKCM	ICGC	RRNSLRRMS	DEG_APCC_DBOX_1	1013:1021	Mutation rewiring degron network	0.2222
p.A1486V	TCGA-EI-6882	READ	TCGA	PRGDLAQME	DEG_APCC_DBOX_1	1481:1489	Mutation altering degron motif	0.5825
p.A1486V	DO229005	COCA	ICGC	PRGDLAQME	DEG_APCC_DBOX_1	1481:1489	Mutation altering degron motif	0.5825
p.A1486V	DO36531	READ	ICGC	PRGDLAQME	DEG_APCC_DBOX_1	1481:1489	Mutation altering degron motif	0.5825
p.E1004K	TCGA-EO-A22R	UCEC	TCGA	RRNSLRRMS	DEG_APCC_DBOX_1	1013:1021	Mutation rewiring degron network	0.0833
p.E1004K	DO222762	COCA	ICGC	RRNSLRRMS	DEG_APCC_DBOX_1	1013:1021	Mutation rewiring degron network	0.0833
p.E1004K	DO42713	UCEC	ICGC	RRNSLRRMS	DEG_APCC_DBOX_1	1013:1021	Mutation rewiring degron network	0.0833
p.D355N	TCGA-EO-A3B0	UCEC	TCGA	VLPFTD	LIG_APCC_ABBA_1	360:365	Mutation rewiring degron network	0.1944
p.D355N	DO219773	UCEC	ICGC	VLPFTD	LIG_APCC_ABBA_1	360:365	Mutation rewiring degron network	0.1944
p.S1022Y	TCGA-EY-A1GI	UCEC	TCGA	RRNSLRRMS	DEG_APCC_DBOX_1	1013:1021	Mutation rewiring degron network	0.3056
p.S1022Y	DO41211	UCEC	ICGC	RRNSLRRMS	DEG_APCC_DBOX_1	1013:1021	Mutation rewiring degron network	0.3056
p.A1479T	TCGA-FI-A2D5	UCEC	TCGA	PRGDLAQME	DEG_APCC_DBOX_1	1481:1489	Mutation rewiring degron network	0.2778
p.A1479T	DO41331	UCEC	ICGC	PRGDLAQME	DEG_APCC_DBOX_1	1481:1489	Mutation rewiring degron network	0.2778
p.L351F	TCGA-FZ-5921	PAAD	TCGA	VLPFTD	LIG_APCC_ABBA_1	360:365	Mutation rewiring degron network	0.0833
p.L351F	DO51688	PAAD	ICGC	VLPFTD	LIG_APCC_ABBA_1	360:365	Mutation rewiring degron network	0.0833
p.P1536S	TCGA-IG-A4QS	ESCA	TCGA	DMADYTYSTVP	CBL_PTK	1543:1553	Mutation rewiring degron network	0.1389
p.R1482W	TCGA-YC-A89H	BLCA	TCGA	PRGDLAQME	DEG_APCC_DBOX_1	1481:1489	Mutation altering degron motif	0.8634
p.R1482W	DO51948	BLCA	ICGC	PRGDLAQME	DEG_APCC_DBOX_1	1481:1489	Mutation altering degron motif	0.8634
p.M1488I	DO50567	BOCA	ICGC	PRGDLAQME	DEG_APCC_DBOX_1	1481:1489	Mutation altering degron motif	0.6507
p.R1472C	DO229365	BTCA	ICGC	PRGDLAQME	DEG_APCC_DBOX_1	1481:1489	Mutation rewiring degron network	0.0833
p.D1484A	DO228935	COCA	ICGC	PRGDLAQME	DEG_APCC_DBOX_1	1481:1489	Mutation altering degron motif	0.6682
p.V1492M	DO222874	COCA	ICGC	PRGDLAQME	DEG_APCC_DBOX_1	1481:1489	Mutation rewiring degron network	0.25
p.R1014C	DO234401	ESAD	ICGC	RRNSLRRMS	DEG_APCC_DBOX_1	1013:1021	Mutation altering degron motif	0.8301
p.T1551I	DO222754	ESCA	ICGC	DMADYTYSTVP	CBL_PTK	1543:1553	Mutation altering degron motif	0.5966
p.V354I	DO233252	GACA	ICGC	VLPFTD	LIG_APCC_ABBA_1	360:365	Mutation rewiring degron network	0.1667
p.V354I	DO229542	UTCA	ICGC	VLPFTD	LIG_APCC_ABBA_1	360:365	Mutation rewiring degron network	0.1667
p.E1012D	DO233693	GACA	ICGC	RRNSLRRMS	DEG_APCC_DBOX_1	1013:1021	Mutation rewiring degron network	0.3056
p.L1406I	DO229041	LICA	ICGC	PPLY	ITCH	1404:1407	Mutation altering degron motif	0.6063
p.S1006L	DO222363	MELA	ICGC	RRNSLRRMS	DEG_APCC_DBOX_1	1013:1021	Mutation rewiring degron network	0.1389
p.A1027T	DO232835	NACA	ICGC	RRNSLRRMS	DEG_APCC_DBOX_1	1013:1021	Mutation rewiring degron network	0.1667
p.P1481H	SIDM01951	Colorectal Carcinoma	GDSC	PRGDLAQME	DEG_APCC_DBOX_1	1481:1489	Mutation altering degron motif	0.6583
p.R1540Q	SIDM00373	Endometrial Carcinoma	GDSC	DMADYTYSTVP	CBL_PTK	1543:1553	Mutation rewiring degron network	0.25
p.R1540Q	SNG-M	endometrium	COSMIC	DMADYTYSTVP	CBL_PTK	1543:1553	Mutation rewiring degron network	0.25
p.R1540W	SIDM00946	T-Lymphoblastic Leukemia	GDSC	DMADYTYSTVP	CBL_PTK	1543:1553	Mutation rewiring degron network	0.25
p.R1540W	SIDM01157	Other Solid Cancers	GDSC	DMADYTYSTVP	CBL_PTK	1543:1553	Mutation rewiring degron network	0.25
p.R1540W	SIDM00867	Glioblastoma	GDSC	DMADYTYSTVP	CBL_PTK	1543:1553	Mutation rewiring degron network	0.25
p.R1540W	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	DMADYTYSTVP	CBL_PTK	1543:1553	Mutation rewiring degron network	0.25
p.R1403C	SIDM00933	Breast Carcinoma	GDSC	PPLY	ITCH	1404:1407	Mutation rewiring degron network	0.3056
p.R1403C	SIDM00386	Ewing's Sarcoma	GDSC	PPLY	ITCH	1404:1407	Mutation rewiring degron network	0.3056
p.R1403C	SIDM00087	Plasma Cell Myeloma	GDSC	PPLY	ITCH	1404:1407	Mutation rewiring degron network	0.3056
p.R1403C	SIDM00742	Non-Small Cell Lung Carcinoma	GDSC	PPLY	ITCH	1404:1407	Mutation rewiring degron network	0.3056
p.R1403C	SIDM00856	Other Solid Cancers	GDSC	PPLY	ITCH	1404:1407	Mutation rewiring degron network	0.3056
p.R1403C	SIDM00992	Thyroid Gland Carcinoma	GDSC	PPLY	ITCH	1404:1407	Mutation rewiring degron network	0.3056
p.R1403C	SIDM00941	Kidney Carcinoma	GDSC	PPLY	ITCH	1404:1407	Mutation rewiring degron network	0.3056
p.R1403C	SIDM00379	Glioma	GDSC	PPLY	ITCH	1404:1407	Mutation rewiring degron network	0.3056
p.R1403C	SIDM01191	Osteosarcoma	GDSC	PPLY	ITCH	1404:1407	Mutation rewiring degron network	0.3056
p.R1397Q	SIDM00193	Colorectal Carcinoma	GDSC	PPLY	ITCH	1404:1407	Mutation rewiring degron network	0.1389
p.R1397Q	ACH-000991	Colon/Colorectal Cancer	CCLE	PPLY	ITCH	1404:1407	Mutation rewiring degron network	0.1389
p.R1397Q	SNU-81	large intestine	COSMIC	PPLY	ITCH	1404:1407	Mutation rewiring degron network	0.1389
p.A1412V	SIDM00660	Colorectal Carcinoma	GDSC	PPLY	ITCH	1404:1407	Mutation rewiring degron network	0.1944
p.A1412V	ACH-000985	Colon/Colorectal Cancer	CCLE	PPLY	ITCH	1404:1407	Mutation rewiring degron network	0.1944
p.A1412V	LS-411N	large intestine	COSMIC	PPLY	ITCH	1404:1407	Mutation rewiring degron network	0.1944
p.V354A	SIDM00716	Squamous Cell Lung Carcinoma	GDSC	VLPFTD	LIG_APCC_ABBA_1	360:365	Mutation rewiring degron network	0.1667
p.R1494S	SIDM00709	Non-Small Cell Lung Carcinoma	GDSC	PRGDLAQME	DEG_APCC_DBOX_1	1481:1489	Mutation rewiring degron network	0.1944
p.R1494S	ACH-000451	Lung Cancer	CCLE	PRGDLAQME	DEG_APCC_DBOX_1	1481:1489	Mutation rewiring degron network	0.1944
p.R1494S	NCI-H2085	lung	COSMIC	PRGDLAQME	DEG_APCC_DBOX_1	1481:1489	Mutation rewiring degron network	0.1944
p.P1404L	SIDM00039	Ovarian Carcinoma	GDSC	PPLY	ITCH	1404:1407	Mutation altering degron motif	0.7582
p.P1481S	SIDM00118	Colorectal Carcinoma	GDSC	PRGDLAQME	DEG_APCC_DBOX_1	1481:1489	Mutation altering degron motif	0.5641
p.T1542I	SIDM01491	Colorectal Carcinoma	GDSC	DMADYTYSTVP	CBL_PTK	1543:1553	Mutation blocking phosphorylation signal	0.75
p.T1542I	ACH-000342	Colon/Colorectal Cancer	CCLE	DMADYTYSTVP	CBL_PTK	1543:1553	Mutation blocking phosphorylation signal	0.75
p.Y1407F	ACH-001719	Ovarian Cancer	CCLE	PPLY	ITCH	1404:1407	Mutation altering degron motif	0.7528
p.R1563Q	SNU-81	large intestine	COSMIC	DMADYTYSTVP	CBL_PTK	1543:1553	Mutation rewiring degron network	0.0556
p.K1491E	KP-N-YS	autonomic ganglia	COSMIC	PRGDLAQME	DEG_APCC_DBOX_1	1481:1489	Mutation rewiring degron network	0.2778
p.P1014A	TE-15	oesophagus	COSMIC	RRNSLRRMS	DEG_APCC_DBOX_1	1013:1021	Mutation altering degron motif	0.7503

DegronMD: protein-targeted degradation, mutation and drug response to degrons

QRICH2

UniProt ID: Q9H0J4

Entrez ID: 84074

Protein name: Glutamine-rich protein 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for QRICH2 in