DegronMD

Uniprot ID: Q9H0J4

Source protein: Glutamine-rich protein 2

Source gene: QRICH2

Class: DEG_APCC_DBOX_1

Location: 1481:1489

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5542

ASA_SCORE: 73.3556

COIL: 0.3957

CONS_SCORE: 0.5615

DSS_SCORE: 0.4185

HELIX: 0.5693

FCONS_SCORE: 1.0497

RIG_SCORE: 0.7304

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1484V	TCGA-AB-2899	LAML	TCGA	PRGDLAQME	DEG_APCC_DBOX_1	0.6674
p.D1484V	DO21529	LAML	ICGC	PRGDLAQME	DEG_APCC_DBOX_1	0.6674
p.G1493W	TCGA-D1-A1NZ	UCEC	TCGA	PRGDLAQME	DEG_APCC_DBOX_1	0.2222
p.G1493W	DO41536	UCEC	ICGC	PRGDLAQME	DEG_APCC_DBOX_1	0.2222
p.A1486V	TCGA-EI-6882	READ	TCGA	PRGDLAQME	DEG_APCC_DBOX_1	0.5825
p.A1486V	DO229005	COCA	ICGC	PRGDLAQME	DEG_APCC_DBOX_1	0.5825
p.A1486V	DO36531	READ	ICGC	PRGDLAQME	DEG_APCC_DBOX_1	0.5825
p.A1479T	TCGA-FI-A2D5	UCEC	TCGA	PRGDLAQME	DEG_APCC_DBOX_1	0.2778
p.A1479T	DO41331	UCEC	ICGC	PRGDLAQME	DEG_APCC_DBOX_1	0.2778
p.R1482W	TCGA-YC-A89H	BLCA	TCGA	PRGDLAQME	DEG_APCC_DBOX_1	0.8634
p.R1482W	DO51948	BLCA	ICGC	PRGDLAQME	DEG_APCC_DBOX_1	0.8634
p.M1488I	DO50567	BOCA	ICGC	PRGDLAQME	DEG_APCC_DBOX_1	0.6507
p.R1472C	DO229365	BTCA	ICGC	PRGDLAQME	DEG_APCC_DBOX_1	0.0833
p.D1484A	DO228935	COCA	ICGC	PRGDLAQME	DEG_APCC_DBOX_1	0.6682
p.V1492M	DO222874	COCA	ICGC	PRGDLAQME	DEG_APCC_DBOX_1	0.25
p.P1481H	SIDM01951	Colorectal Carcinoma	GDSC	PRGDLAQME	DEG_APCC_DBOX_1	0.6583
p.R1494S	SIDM00709	Non-Small Cell Lung Carcinoma	GDSC	PRGDLAQME	DEG_APCC_DBOX_1	0.1944
p.R1494S	ACH-000451	Lung Cancer	CCLE	PRGDLAQME	DEG_APCC_DBOX_1	0.1944
p.R1494S	NCI-H2085	lung	COSMIC	PRGDLAQME	DEG_APCC_DBOX_1	0.1944
p.P1481S	SIDM00118	Colorectal Carcinoma	GDSC	PRGDLAQME	DEG_APCC_DBOX_1	0.5641
p.K1491E	KP-N-YS	autonomic_ganglia	COSMIC	PRGDLAQME	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H0J4	Glutamine-rich protein 2	DEG_APCC_DBOX_1	1481:1489	PRGDLAQME	APC,CDC20,FZR1	0.5542	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons