DegronMD

Uniprot ID: Q9H0J4

Source protein: Glutamine-rich protein 2

Source gene: QRICH2

Class: CBL_PTK

Location: 1543:1553

E3 ligase: CBL

DEGRON score: 0.7299

ASA_SCORE: 67.7636

COIL: 0.7093

CONS_SCORE: 0.5132

DSS_SCORE: 0.2532

HELIX: 0.1331

FCONS_SCORE: 0.9494

RIG_SCORE: 0.8144

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1543Y	TCGA-AX-A2HD	UCEC	TCGA	DMADYTYSTVP	CBL_PTK	0.7325
p.D1543Y	DO42608	UCEC	ICGC	DMADYTYSTVP	CBL_PTK	0.7325
p.S1535F	TCGA-D9-A6EC	SKCM	TCGA	DMADYTYSTVP	CBL_PTK	0.1111
p.S1535F	DO50291	SKCM	ICGC	DMADYTYSTVP	CBL_PTK	0.1111
p.P1536S	TCGA-IG-A4QS	ESCA	TCGA	DMADYTYSTVP	CBL_PTK	0.1389
p.T1551I	DO222754	ESCA	ICGC	DMADYTYSTVP	CBL_PTK	0.5966
p.R1540Q	SIDM00373	Endometrial Carcinoma	GDSC	DMADYTYSTVP	CBL_PTK	0.25
p.R1540Q	SNG-M	endometrium	COSMIC	DMADYTYSTVP	CBL_PTK	0.25
p.R1540W	SIDM00946	T-Lymphoblastic Leukemia	GDSC	DMADYTYSTVP	CBL_PTK	0.25
p.R1540W	SIDM01157	Other Solid Cancers	GDSC	DMADYTYSTVP	CBL_PTK	0.25
p.R1540W	SIDM00867	Glioblastoma	GDSC	DMADYTYSTVP	CBL_PTK	0.25
p.R1540W	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	DMADYTYSTVP	CBL_PTK	0.25
p.T1542I	SIDM01491	Colorectal Carcinoma	GDSC	DMADYTYSTVP	CBL_PTK	0.75
p.T1542I	ACH-000342	Colon/Colorectal Cancer	CCLE	DMADYTYSTVP	CBL_PTK	0.75
p.R1563Q	SNU-81	large_intestine	COSMIC	DMADYTYSTVP	CBL_PTK	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H0J4	Glutamine-rich protein 2	CBL_PTK	1543:1553	DMADYTYSTVP	CBL	0.7299	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons