DegronMD

Uniprot ID: Q9H0J4

Source protein: Glutamine-rich protein 2

Source gene: QRICH2

Class: LIG_APCC_ABBA_1

Location: 360:365

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6057

ASA_SCORE: 82.35

COIL: 0.8338

CONS_SCORE: 0.2246

DSS_SCORE: 0.2843

HELIX: 0.052

FCONS_SCORE: 0.4933

RIG_SCORE: 0.7975

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D355N	TCGA-EO-A3B0	UCEC	TCGA	VLPFTD	LIG_APCC_ABBA_1	0.1944
p.D355N	DO219773	UCEC	ICGC	VLPFTD	LIG_APCC_ABBA_1	0.1944
p.L351F	TCGA-FZ-5921	PAAD	TCGA	VLPFTD	LIG_APCC_ABBA_1	0.0833
p.L351F	DO51688	PAAD	ICGC	VLPFTD	LIG_APCC_ABBA_1	0.0833
p.V354I	DO233252	GACA	ICGC	VLPFTD	LIG_APCC_ABBA_1	0.1667
p.V354I	DO229542	UTCA	ICGC	VLPFTD	LIG_APCC_ABBA_1	0.1667
p.V354A	SIDM00716	Squamous Cell Lung Carcinoma	GDSC	VLPFTD	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BX63	Fanconi anemia group J protein	LIG_APCC_ABBA_1	1046:1051	VLPFTD	APC,CDC20,FZR1	0.9936	More...
Q9H0J4	Glutamine-rich protein 2	LIG_APCC_ABBA_1	360:365	VLPFTD	APC,CDC20,FZR1	0.6057	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons