DegronMD

Uniprot ID: Q9BX63

Source protein: Fanconi anemia group J protein

Source gene: BRIP1

Class: LIG_APCC_ABBA_1

Location: 1046:1051

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9936

ASA_SCORE: 86.2

COIL: 0.8035

CONS_SCORE: 0.2556

DSS_SCORE: 0.4371

HELIX: 0.1055

FCONS_SCORE: 1.0009

RIG_SCORE: 0.7876

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1051N	TCGA-DK-AA6S	BLCA	TCGA	VLPFTD	LIG_APCC_ABBA_1	0.6932
p.D1051N	DO219007	BLCA	ICGC	VLPFTD	LIG_APCC_ABBA_1	0.6932
p.S1055F	TCGA-E6-A1LX	UCEC	TCGA	VLPFTD	LIG_APCC_ABBA_1	0.2222
p.S1055F	DO41020	UCEC	ICGC	VLPFTD	LIG_APCC_ABBA_1	0.2222
p.V1060I	TCGA-F4-6570	COAD	TCGA	VLPFTD	LIG_APCC_ABBA_1	0.0833
p.V1060I	DO10443	COAD	ICGC	VLPFTD	LIG_APCC_ABBA_1	0.0833
p.N1061S	TCGA-VQ-A8P2	STAD	TCGA	VLPFTD	LIG_APCC_ABBA_1	0.0556
p.N1061S	DO51761	STAD	ICGC	VLPFTD	LIG_APCC_ABBA_1	0.0556
p.E1054A	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	VLPFTD	LIG_APCC_ABBA_1	0.25
p.E1054A	ACH-000900	Lung Cancer	CCLE	VLPFTD	LIG_APCC_ABBA_1	0.25
p.E1054A	NCI-H23	lung	COSMIC	VLPFTD	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BX63	Fanconi anemia group J protein	LIG_APCC_ABBA_1	1046:1051	VLPFTD	APC,CDC20,FZR1	0.9936	More...
Q9H0J4	Glutamine-rich protein 2	LIG_APCC_ABBA_1	360:365	VLPFTD	APC,CDC20,FZR1	0.6057	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons