DegronMD - Q9BX63(BRIP1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y110F	TCGA-A8-A08F	BRCA	TCGA	PSTPPSE	DEG_SCF_FBW7_2	111:117	Mutation blocking phosphorylation signal	0.75
p.Y110F	DO6152	BRCA	ICGC	PSTPPSE	DEG_SCF_FBW7_2	111:117	Mutation blocking phosphorylation signal	0.75
p.F108S	TCGA-AP-A059	UCEC	TCGA	PSTPPSE	DEG_SCF_FBW7_2	111:117	Mutation rewiring degron network	0.25
p.F108S	DO41361	UCEC	ICGC	PSTPPSE	DEG_SCF_FBW7_2	111:117	Mutation rewiring degron network	0.25
p.S123L	TCGA-AP-A1DH	UCEC	TCGA	PSTPPSE	DEG_SCF_FBW7_2	111:117	Mutation rewiring degron network	0.1667
p.S123L	TCGA-CV-A6K1	HNSC	TCGA	PSTPPSE	DEG_SCF_FBW7_2	111:117	Mutation rewiring degron network	0.1667
p.S123L	DO52078	HNSC	ICGC	PSTPPSE	DEG_SCF_FBW7_2	111:117	Mutation rewiring degron network	0.1667
p.S123L	DO43995	UCEC	ICGC	PSTPPSE	DEG_SCF_FBW7_2	111:117	Mutation rewiring degron network	0.1667
p.D1051N	TCGA-DK-AA6S	BLCA	TCGA	VLPFTD	LIG_APCC_ABBA_1	1046:1051	Mutation altering degron motif	0.6932
p.D1051N	DO219007	BLCA	ICGC	VLPFTD	LIG_APCC_ABBA_1	1046:1051	Mutation altering degron motif	0.6932
p.S1055F	TCGA-E6-A1LX	UCEC	TCGA	VLPFTD	LIG_APCC_ABBA_1	1046:1051	Mutation rewiring degron network	0.2222
p.S1055F	DO41020	UCEC	ICGC	VLPFTD	LIG_APCC_ABBA_1	1046:1051	Mutation rewiring degron network	0.2222
p.V1060I	TCGA-F4-6570	COAD	TCGA	VLPFTD	LIG_APCC_ABBA_1	1046:1051	Mutation rewiring degron network	0.0833
p.V1060I	DO10443	COAD	ICGC	VLPFTD	LIG_APCC_ABBA_1	1046:1051	Mutation rewiring degron network	0.0833
p.N1061S	TCGA-VQ-A8P2	STAD	TCGA	VLPFTD	LIG_APCC_ABBA_1	1046:1051	Mutation rewiring degron network	0.0556
p.N1061S	DO51761	STAD	ICGC	VLPFTD	LIG_APCC_ABBA_1	1046:1051	Mutation rewiring degron network	0.0556
p.P115H	TCGA-VQ-A8PP	STAD	TCGA	PSTPPSE	DEG_SCF_FBW7_2	111:117	Mutation altering degron motif	0.6583
p.P115H	DO51774	STAD	ICGC	PSTPPSE	DEG_SCF_FBW7_2	111:117	Mutation altering degron motif	0.6583
p.N101K	DO229029	LICA	ICGC	PSTPPSE	DEG_SCF_FBW7_2	111:117	Mutation rewiring degron network	0.0556
p.N109S	DO27875	ORCA	ICGC	PSTPPSE	DEG_SCF_FBW7_2	111:117	Mutation rewiring degron network	0.2778
p.T104I	SIDM00924	Other Solid Cancers	GDSC	PSTPPSE	DEG_SCF_FBW7_2	111:117	Mutation rewiring degron network	0.1389
p.T104I	ACH-000867	Lung Cancer	CCLE	PSTPPSE	DEG_SCF_FBW7_2	111:117	Mutation rewiring degron network	0.1389
p.T104I	ChaGo-K-1	lung	COSMIC	PSTPPSE	DEG_SCF_FBW7_2	111:117	Mutation rewiring degron network	0.1389
p.H107R	SIDM00057	Neuroblastoma	GDSC	PSTPPSE	DEG_SCF_FBW7_2	111:117	Mutation rewiring degron network	0.2222
p.H107R	SIDM00552	Rhabdomyosarcoma	GDSC	PSTPPSE	DEG_SCF_FBW7_2	111:117	Mutation rewiring degron network	0.2222
p.H107R	ACH-000607	Rhabdoid	CCLE	PSTPPSE	DEG_SCF_FBW7_2	111:117	Mutation rewiring degron network	0.2222
p.H107R	KYM-1	soft tissue	COSMIC	PSTPPSE	DEG_SCF_FBW7_2	111:117	Mutation rewiring degron network	0.2222
p.E1054A	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	VLPFTD	LIG_APCC_ABBA_1	1046:1051	Mutation rewiring degron network	0.25
p.E1054A	ACH-000900	Lung Cancer	CCLE	VLPFTD	LIG_APCC_ABBA_1	1046:1051	Mutation rewiring degron network	0.25
p.E1054A	NCI-H23	lung	COSMIC	VLPFTD	LIG_APCC_ABBA_1	1046:1051	Mutation rewiring degron network	0.25

Kaplan plot for BRIP1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BRIP1

UniProt ID: Q9BX63

Entrez ID: 83990

Protein name: Fanconi anemia group J protein (Protein FACJ) (EC 3.6.4.13) (ATP-dependent RNA helicase BRIP1) (BRCA1-associated C-terminal helicase 1) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for BRIP1 in