DegronMD

Uniprot ID: Q9BX63

Source protein: Fanconi anemia group J protein

Source gene: BRIP1

Class: DEG_SCF_FBW7_2

Location: 111:117

E3 ligase: FBXW7

DEGRON score: 0.9027

ASA_SCORE: 74.1714

COIL: 0.9103

CONS_SCORE: 0.285

DSS_SCORE: 0.6567

HELIX: 0.0519

FCONS_SCORE: 1.0207

RIG_SCORE: 0.5701

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y110F	TCGA-A8-A08F	BRCA	TCGA	PSTPPSE	DEG_SCF_FBW7_2	0.75
p.Y110F	DO6152	BRCA	ICGC	PSTPPSE	DEG_SCF_FBW7_2	0.75
p.F108S	TCGA-AP-A059	UCEC	TCGA	PSTPPSE	DEG_SCF_FBW7_2	0.25
p.F108S	DO41361	UCEC	ICGC	PSTPPSE	DEG_SCF_FBW7_2	0.25
p.S123L	TCGA-AP-A1DH	UCEC	TCGA	PSTPPSE	DEG_SCF_FBW7_2	0.1667
p.S123L	TCGA-CV-A6K1	HNSC	TCGA	PSTPPSE	DEG_SCF_FBW7_2	0.1667
p.S123L	DO52078	HNSC	ICGC	PSTPPSE	DEG_SCF_FBW7_2	0.1667
p.S123L	DO43995	UCEC	ICGC	PSTPPSE	DEG_SCF_FBW7_2	0.1667
p.P115H	TCGA-VQ-A8PP	STAD	TCGA	PSTPPSE	DEG_SCF_FBW7_2	0.6583
p.P115H	DO51774	STAD	ICGC	PSTPPSE	DEG_SCF_FBW7_2	0.6583
p.N101K	DO229029	LICA	ICGC	PSTPPSE	DEG_SCF_FBW7_2	0.0556
p.N109S	DO27875	ORCA	ICGC	PSTPPSE	DEG_SCF_FBW7_2	0.2778
p.T104I	SIDM00924	Other Solid Cancers	GDSC	PSTPPSE	DEG_SCF_FBW7_2	0.1389
p.T104I	ACH-000867	Lung Cancer	CCLE	PSTPPSE	DEG_SCF_FBW7_2	0.1389
p.T104I	ChaGo-K-1	lung	COSMIC	PSTPPSE	DEG_SCF_FBW7_2	0.1389
p.H107R	SIDM00057	Neuroblastoma	GDSC	PSTPPSE	DEG_SCF_FBW7_2	0.2222
p.H107R	SIDM00552	Rhabdomyosarcoma	GDSC	PSTPPSE	DEG_SCF_FBW7_2	0.2222
p.H107R	ACH-000607	Rhabdoid	CCLE	PSTPPSE	DEG_SCF_FBW7_2	0.2222
p.H107R	KYM-1	soft_tissue	COSMIC	PSTPPSE	DEG_SCF_FBW7_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BX63	Fanconi anemia group J protein	DEG_SCF_FBW7_2	111:117	PSTPPSE	FBXW7	0.9027	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons