DegronMD

Uniprot ID: Q9H0J4

Source protein: Glutamine-rich protein 2

Source gene: QRICH2

Class: DEG_APCC_DBOX_1

Location: 1013:1021

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.739

ASA_SCORE: 81.4444

COIL: 0.5777

CONS_SCORE: 0.3529

DSS_SCORE: 0.3707

HELIX: 0.2949

FCONS_SCORE: 1.1796

RIG_SCORE: 0.7004

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1029Q	TCGA-69-7765	LUAD	TCGA	RRNSLRRMS	DEG_APCC_DBOX_1	0.1111
p.E1029Q	DO23580	LUAD	ICGC	RRNSLRRMS	DEG_APCC_DBOX_1	0.1111
p.P1025L	TCGA-EE-A2MN	SKCM	TCGA	RRNSLRRMS	DEG_APCC_DBOX_1	0.2222
p.P1025L	DO222438	MELA	ICGC	RRNSLRRMS	DEG_APCC_DBOX_1	0.2222
p.P1025L	DO37423	SKCM	ICGC	RRNSLRRMS	DEG_APCC_DBOX_1	0.2222
p.E1004K	TCGA-EO-A22R	UCEC	TCGA	RRNSLRRMS	DEG_APCC_DBOX_1	0.0833
p.E1004K	DO222762	COCA	ICGC	RRNSLRRMS	DEG_APCC_DBOX_1	0.0833
p.E1004K	DO42713	UCEC	ICGC	RRNSLRRMS	DEG_APCC_DBOX_1	0.0833
p.S1022Y	TCGA-EY-A1GI	UCEC	TCGA	RRNSLRRMS	DEG_APCC_DBOX_1	0.3056
p.S1022Y	DO41211	UCEC	ICGC	RRNSLRRMS	DEG_APCC_DBOX_1	0.3056
p.R1014C	DO234401	ESAD	ICGC	RRNSLRRMS	DEG_APCC_DBOX_1	0.8301
p.E1012D	DO233693	GACA	ICGC	RRNSLRRMS	DEG_APCC_DBOX_1	0.3056
p.S1006L	DO222363	MELA	ICGC	RRNSLRRMS	DEG_APCC_DBOX_1	0.1389
p.A1027T	DO232835	NACA	ICGC	RRNSLRRMS	DEG_APCC_DBOX_1	0.1667
p.P1014A	TE-15	oesophagus	COSMIC	RRNSLRRMS	DEG_APCC_DBOX_1	0.7503

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H0J4	Glutamine-rich protein 2	DEG_APCC_DBOX_1	1013:1021	RRNSLRRMS	APC,CDC20,FZR1	0.739	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons