DegronMD - Q9BXF3(CECR2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H1148L	TCGA-63-5131	LUSC	TCGA	PPLY	ITCH	1137:1140	Mutation rewiring degron network	0.1111
p.H1148L	DO26898	LUSC	ICGC	PPLY	ITCH	1137:1140	Mutation rewiring degron network	0.1111
p.R334S	TCGA-EE-A29L	SKCM	TCGA	ERQILLAVQ	DEG_APCC_DBOX_1	337:345	Mutation rewiring degron network	0.25
p.R334S	DO37835	SKCM	ICGC	ERQILLAVQ	DEG_APCC_DBOX_1	337:345	Mutation rewiring degron network	0.25
p.A1131S	TCGA-EE-A29L	SKCM	TCGA	PPLY	ITCH	1137:1140	Mutation rewiring degron network	0.1667
p.A1131S	DO37835	SKCM	ICGC	PPLY	ITCH	1137:1140	Mutation rewiring degron network	0.1667
p.G1141S	TCGA-EE-A2A2	SKCM	TCGA	PPLY	ITCH	1137:1140	Mutation rewiring degron network	0.3056
p.G1141S	DO37583	SKCM	ICGC	PPLY	ITCH	1137:1140	Mutation rewiring degron network	0.3056
p.R346H	TCGA-IB-7652	PAAD	TCGA	ERQILLAVQ	DEG_APCC_DBOX_1	337:345	Mutation rewiring degron network	0.3056
p.R346H	DO46667	PAAD	ICGC	ERQILLAVQ	DEG_APCC_DBOX_1	337:345	Mutation rewiring degron network	0.3056
p.R1140G	TCGA-L5-A4OI	ESCA	TCGA	PPLY	ITCH	1137:1140	Mutation altering degron motif	0.7568
p.R334C	TCGA-MX-A5UJ	STAD	TCGA	ERQILLAVQ	DEG_APCC_DBOX_1	337:345	Mutation rewiring degron network	0.25
p.R334C	DO48547	STAD	ICGC	ERQILLAVQ	DEG_APCC_DBOX_1	337:345	Mutation rewiring degron network	0.25
p.K355M	TCGA-WZ-A7V5	TGCT	TCGA	ERQILLAVQ	DEG_APCC_DBOX_1	337:345	Mutation rewiring degron network	0.0556
p.H1147N	DO224802	BRCA	ICGC	PPLY	ITCH	1137:1140	Mutation rewiring degron network	0.1389
p.S1147L	SIDM00373	Endometrial Carcinoma	GDSC	PPLY	ITCH	1137:1140	Mutation rewiring degron network	0.1389
p.S1147L	ACH-000974	Endometrial/Uterine Cancer	CCLE	PPLY	ITCH	1137:1140	Mutation rewiring degron network	0.1389
p.N343H	SIDM00967	Ovarian Carcinoma	GDSC	ERQILLAVQ	DEG_APCC_DBOX_1	337:345	Mutation altering degron motif	0.7423
p.N343H	ACH-002181	Ovarian Cancer	CCLE	ERQILLAVQ	DEG_APCC_DBOX_1	337:345	Mutation altering degron motif	0.7423
p.N343H	OVCA420	ovary	COSMIC	ERQILLAVQ	DEG_APCC_DBOX_1	337:345	Mutation altering degron motif	0.7423
p.T338I	SIDM00221	Melanoma	GDSC	ERQILLAVQ	DEG_APCC_DBOX_1	337:345	Mutation altering degron motif	0.7078
p.T338I	ACH-002388	Skin Cancer	CCLE	ERQILLAVQ	DEG_APCC_DBOX_1	337:345	Mutation altering degron motif	0.7078
p.G332R	SIDM00909	Melanoma	GDSC	ERQILLAVQ	DEG_APCC_DBOX_1	337:345	Mutation substituting flanking lysine	0.3056
p.G332R	ACH-000644	Skin Cancer	CCLE	ERQILLAVQ	DEG_APCC_DBOX_1	337:345	Mutation substituting flanking lysine	0.3056
p.G332R	COLO-829	skin	COSMIC	ERQILLAVQ	DEG_APCC_DBOX_1	337:345	Mutation substituting flanking lysine	0.3056
p.A1150V	SIDM00980	Gastric Carcinoma	GDSC	PPLY	ITCH	1137:1140	Mutation rewiring degron network	0.0556
p.A1150V	ACH-000948	Gastric Cancer	CCLE	PPLY	ITCH	1137:1140	Mutation rewiring degron network	0.0556
p.A1150V	23132-87	stomach	COSMIC	PPLY	ITCH	1137:1140	Mutation rewiring degron network	0.0556
p.K1143T	SIDM01582	Gastric Carcinoma	GDSC	PPLY	ITCH	1137:1140	Mutation rewiring degron network	0.25
p.K1143T	ACH-000507	Gastric Cancer	CCLE	PPLY	ITCH	1137:1140	Mutation rewiring degron network	0.25
p.M352R	ACH-001524	Skin Cancer	CCLE	ERQILLAVQ	DEG_APCC_DBOX_1	337:345	Mutation rewiring degron network	0.1389
p.P347L	ACH-001550	Skin Cancer	CCLE	ERQILLAVQ	DEG_APCC_DBOX_1	337:345	Mutation rewiring degron network	0.2778
p.E341K	EJM	haematopoietic and lymphoid tissue	COSMIC	ERQILLAVQ	DEG_APCC_DBOX_1	337:345	Mutation altering degron motif	0.7022
p.P1147L	SK-LMS-1	soft tissue	COSMIC	PPLY	ITCH	1137:1140	Mutation rewiring degron network	0.1389
p.Q339R	EN	endometrium	COSMIC	ERQILLAVQ	DEG_APCC_DBOX_1	337:345	Mutation altering degron motif	0.6218
p.Q1142H	8-MG-BA	central nervous system	COSMIC	PPLY	ITCH	1137:1140	Mutation rewiring degron network	0.2778
p.P1137S	SW684	soft tissue	COSMIC	PPLY	ITCH	1137:1140	Mutation altering degron motif	0.6752
p.P1138Q	NCI-H2227	lung	COSMIC	PPLY	ITCH	1137:1140	Mutation altering degron motif	0.7035
p.G1150R	CGTH-W-1	thyroid	COSMIC	PPLY	ITCH	1137:1140	Mutation rewiring degron network	0.0556
p.E337Q	CAL-148	breast	COSMIC	ERQILLAVQ	DEG_APCC_DBOX_1	337:345	Mutation altering degron motif	0.5633

Kaplan plot for CECR2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CECR2

UniProt ID: Q9BXF3

Entrez ID: 27443

Protein name: Cat eye syndrome critical region protein 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CECR2 in