DegronMD

Uniprot ID: Q9BXF3

Source protein: Cat eye syndrome critical region protein 2

Source gene: CECR2

Class: DEG_APCC_DBOX_1

Location: 337:345

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5608

ASA_SCORE: 102.5333

COIL: 0.0882

CONS_SCORE: 0.3152

DSS_SCORE: 0.4027

HELIX: 0.914

FCONS_SCORE: 1.1079

RIG_SCORE: 0.807

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N343H	SIDM00967	Ovarian Carcinoma	GDSC	ERQILLAVQ	DEG_APCC_DBOX_1	0.7423
p.N343H	ACH-002181	Ovarian Cancer	CCLE	ERQILLAVQ	DEG_APCC_DBOX_1	0.7423
p.N343H	OVCA420	ovary	COSMIC	ERQILLAVQ	DEG_APCC_DBOX_1	0.7423
p.T338I	SIDM00221	Melanoma	GDSC	ERQILLAVQ	DEG_APCC_DBOX_1	0.7078
p.T338I	ACH-002388	Skin Cancer	CCLE	ERQILLAVQ	DEG_APCC_DBOX_1	0.7078
p.E341K	EJM	haematopoietic_and_lymphoid_tissue	COSMIC	ERQILLAVQ	DEG_APCC_DBOX_1	0.7022
p.Q339R	EN	endometrium	COSMIC	ERQILLAVQ	DEG_APCC_DBOX_1	0.6218
p.E337Q	CAL-148	breast	COSMIC	ERQILLAVQ	DEG_APCC_DBOX_1	0.5633
p.R346H	TCGA-IB-7652	PAAD	TCGA	ERQILLAVQ	DEG_APCC_DBOX_1	0.3056
p.R346H	DO46667	PAAD	ICGC	ERQILLAVQ	DEG_APCC_DBOX_1	0.3056
p.G332R	SIDM00909	Melanoma	GDSC	ERQILLAVQ	DEG_APCC_DBOX_1	0.3056
p.G332R	ACH-000644	Skin Cancer	CCLE	ERQILLAVQ	DEG_APCC_DBOX_1	0.3056
p.G332R	COLO-829	skin	COSMIC	ERQILLAVQ	DEG_APCC_DBOX_1	0.3056
p.P347L	ACH-001550	Skin Cancer	CCLE	ERQILLAVQ	DEG_APCC_DBOX_1	0.2778
p.R334S	TCGA-EE-A29L	SKCM	TCGA	ERQILLAVQ	DEG_APCC_DBOX_1	0.25
p.R334S	DO37835	SKCM	ICGC	ERQILLAVQ	DEG_APCC_DBOX_1	0.25
p.R334C	TCGA-MX-A5UJ	STAD	TCGA	ERQILLAVQ	DEG_APCC_DBOX_1	0.25
p.R334C	DO48547	STAD	ICGC	ERQILLAVQ	DEG_APCC_DBOX_1	0.25
p.M352R	ACH-001524	Skin Cancer	CCLE	ERQILLAVQ	DEG_APCC_DBOX_1	0.1389
p.K355M	TCGA-WZ-A7V5	TGCT	TCGA	ERQILLAVQ	DEG_APCC_DBOX_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BXF3	Cat eye syndrome critical region protein 2	DEG_APCC_DBOX_1	337:345	ERQILLAVQ	APC,CDC20,FZR1	0.5608	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons