DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PPLY
Uniprot ID:
Q13443
Source protein:
Disintegrin and metalloproteinase domain-containing protein 9
Source gene:
ADAM9
Class:
ITCH
Location:
812:815
E3 ligase:
ITCH,NEDD4
DEGRON score:
0.9977
ASA_SCORE:
104.95
COIL:
0.961
CONS_SCORE:
0.4481
DSS_SCORE:
0.7682
HELIX:
0.0158
FCONS_SCORE:
1.0765
RIG_SCORE:
0.6576
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P813S
SIDM00545
Melanoma
GDSC
PPLY
ITCH
0.6752
p.P813S
SIDM00190
Melanoma
GDSC
PPLY
ITCH
0.6752
p.P813S
ACH-000987
Skin Cancer
CCLE
PPLY
ITCH
0.6752
p.P813S
ACH-002097
Skin Cancer
CCLE
PPLY
ITCH
0.6752
p.P813S
CP66-MEL
skin
COSMIC
PPLY
ITCH
0.6752
p.P813S
Mewo
skin
COSMIC
PPLY
ITCH
0.6752
p.R807H
TCGA-34-2596
LUSC
TCGA
PPLY
ITCH
0.1944
p.R807H
DO26508
LUSC
ICGC
PPLY
ITCH
0.1944
Showing 1 to 8 of 8 entries
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Drug responses associated with ADAM9 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of PPLY
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P82914
28S ribosomal protein S15, mitochondrial
ITCH
192:195
PPLY
ITCH,NEDD4
0.8188
More...
Q6DCA0
AMMECR1-like protein
ITCH
303:306
PPLY
ITCH,NEDD4
0.9894
More...
Q86XL3
Ankyrin repeat and LEM domain-containing protein 2
ITCH
196:199
PPLY
ITCH,NEDD4
0.9937
More...
Q8TBH0
Arrestin domain-containing protein 2
ITCH
385:388
PPLY
ITCH,NEDD4
0.9798
More...
Q96B67
Arrestin domain-containing protein 3
ITCH
391:394
PPLY
ITCH,NEDD4
0.9963
More...
Q8NCT1
Arrestin domain-containing protein 4
ITCH
395:398
PPLY
ITCH,NEDD4
0.8354
More...
O95429
BAG family molecular chaperone regulator 4
ITCH
34:37
PPLY
ITCH,NEDD4
0.9898
More...
Q9BXF3
Cat eye syndrome critical region protein 2
ITCH
1137:1140
PPLY
ITCH,NEDD4
0.8075
More...
Q9P209
Centrosomal protein of 72 kDa
ITCH
278:281
PPLY
ITCH,NEDD4
0.7298
More...
Q8NCG7
Diacylglycerol lipase-beta
ITCH
588:591
PPLY
ITCH,NEDD4
0.838
More...
Q13443
Disintegrin and metalloproteinase domain-containing protein 9
ITCH
812:815
PPLY
ITCH,NEDD4
0.9977
More...
Q8TDM6
Disks large homolog 5
ITCH
1166:1169
PPLY
ITCH,NEDD4
0.9662
More...
P54098
DNA polymerase subunit gamma-1
ITCH
128:131
PPLY
ITCH,NEDD4
0.9114
More...
Q7Z6E9
E3 ubiquitin-protein ligase RBBP6
ITCH
562:565
PPLY
ITCH,NEDD4
0.9715
More...
P62508
Estrogen-related receptor gamma
ITCH
82:85
PPLY
ITCH,NEDD4
0.9981
More...
Q99958
Forkhead box protein C2
ITCH
485:488
PPLY
ITCH,NEDD4
0.9946
More...
Q9P0K8
Forkhead box protein J2
ITCH
230:233
PPLY
ITCH,NEDD4
0.8417
More...
Q2KHR3
Glutamine and serine-rich protein 1
ITCH
370:373
PPLY
ITCH,NEDD4
0.8458
More...
Q9H0J4
Glutamine-rich protein 2
ITCH
1404:1407
PPLY
ITCH,NEDD4
0.9172
More...
Q96CC6
Inactive rhomboid protein 1
ITCH
141:144
PPLY
ITCH,NEDD4
0.9927
More...
Q8NDH2
Leucine-rich repeat transmembrane protein CCDC168
ITCH
5560:5563
PPLY
ITCH,NEDD4
0.6888
More...
Q9P2G4
Microtubule-associated protein 10
ITCH
302:305
PPLY
ITCH,NEDD4
0.9678
More...
Q9HB07
MYG1 exonuclease
ITCH
17:20
PPLY
ITCH,NEDD4
0.6345
More...
Q02080
Myocyte-specific enhancer factor 2B
ITCH
198:201
PPLY
ITCH,NEDD4
0.992
More...
Q5VTT5
Myomesin-3
ITCH
824:827
PPLY
ITCH,NEDD4
0.901
More...
Showing 1 to 25 of 51 entries
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