DegronMD

Uniprot ID: Q7Z6E9

Source protein: E3 ubiquitin-protein ligase RBBP6

Source gene: RBBP6

Class: ITCH

Location: 562:565

E3 ligase: ITCH,NEDD4

DEGRON score: 0.9715

ASA_SCORE: 108.1

COIL: 0.9758

CONS_SCORE: 0.4299

DSS_SCORE: 0.5255

HELIX: 0.0115

FCONS_SCORE: 1.222

RIG_SCORE: 0.5323

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P563L	TCGA-56-7582	LUSC	TCGA	PPLY	ITCH	0.7582
p.P563L	DO26976	LUSC	ICGC	PPLY	ITCH	0.7582
p.Y565F	DO228299	LICA	ICGC	PPLY	ITCH	0.7528
p.P566S	TCGA-G2-A2EC	BLCA	TCGA	PPLY	ITCH	0.3056
p.P566S	DO651	BLCA	ICGC	PPLY	ITCH	0.3056
p.P561Q	SIDM00077	Oral Cavity Carcinoma	GDSC	PPLY	ITCH	0.3056
p.P561Q	ACH-001331	Head and Neck Cancer	CCLE	PPLY	ITCH	0.3056
p.P561Q	BICR10	upper_aerodigestive_tract	COSMIC	PPLY	ITCH	0.3056
p.P566L	SIDM01424	B-Lymphoblastic Leukemia	GDSC	PPLY	ITCH	0.3056
p.P566L	ACH-000782	Leukemia	CCLE	PPLY	ITCH	0.3056
p.P566L	ACH-001735	Leukemia	CCLE	PPLY	ITCH	0.3056
p.P567S	SIDM01608	Endometrial Carcinoma	GDSC	PPLY	ITCH	0.2778
p.P567S	ACH-000990	Endometrial/Uterine Cancer	CCLE	PPLY	ITCH	0.2778
p.V557L	DO229019	LICA	ICGC	PPLY	ITCH	0.1944
p.V555G	TCGA-F7-7848	HNSC	TCGA	PPLY	ITCH	0.1389
p.V555G	DO14198	HNSC	ICGC	PPLY	ITCH	0.1389
p.P573S	TCGA-FW-A3R5	SKCM	TCGA	PPLY	ITCH	0.1111
p.P573S	TCGA-W3-AA1R	SKCM	TCGA	PPLY	ITCH	0.1111
p.P573S	DO37406	SKCM	ICGC	PPLY	ITCH	0.1111
p.P573S	DO51275	SKCM	ICGC	PPLY	ITCH	0.1111
p.P554T	ACH-000586	Lung Cancer	CCLE	PPLY	ITCH	0.1111
p.P554T	NCI-H1876	lung	COSMIC	PPLY	ITCH	0.1111
p.T553A	DO23527	LIRI	ICGC	PPLY	ITCH	0.0833
p.P575S	TCGA-EE-A3JE	SKCM	TCGA	PPLY	ITCH	0.0556
p.P575S	TCGA-FS-A1ZP	SKCM	TCGA	PPLY	ITCH	0.0556

Showing 1 to 25 of 29 entries

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Drug responses associated with RBBP6 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PPLY

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P82914	28S ribosomal protein S15, mitochondrial	ITCH	192:195	PPLY	ITCH,NEDD4	0.8188	More...
Q6DCA0	AMMECR1-like protein	ITCH	303:306	PPLY	ITCH,NEDD4	0.9894	More...
Q86XL3	Ankyrin repeat and LEM domain-containing protein 2	ITCH	196:199	PPLY	ITCH,NEDD4	0.9937	More...
Q8TBH0	Arrestin domain-containing protein 2	ITCH	385:388	PPLY	ITCH,NEDD4	0.9798	More...
Q96B67	Arrestin domain-containing protein 3	ITCH	391:394	PPLY	ITCH,NEDD4	0.9963	More...
Q8NCT1	Arrestin domain-containing protein 4	ITCH	395:398	PPLY	ITCH,NEDD4	0.8354	More...
O95429	BAG family molecular chaperone regulator 4	ITCH	34:37	PPLY	ITCH,NEDD4	0.9898	More...
Q9BXF3	Cat eye syndrome critical region protein 2	ITCH	1137:1140	PPLY	ITCH,NEDD4	0.8075	More...
Q9P209	Centrosomal protein of 72 kDa	ITCH	278:281	PPLY	ITCH,NEDD4	0.7298	More...
Q8NCG7	Diacylglycerol lipase-beta	ITCH	588:591	PPLY	ITCH,NEDD4	0.838	More...
Q13443	Disintegrin and metalloproteinase domain-containing protein 9	ITCH	812:815	PPLY	ITCH,NEDD4	0.9977	More...
Q8TDM6	Disks large homolog 5	ITCH	1166:1169	PPLY	ITCH,NEDD4	0.9662	More...
P54098	DNA polymerase subunit gamma-1	ITCH	128:131	PPLY	ITCH,NEDD4	0.9114	More...
Q7Z6E9	E3 ubiquitin-protein ligase RBBP6	ITCH	562:565	PPLY	ITCH,NEDD4	0.9715	More...
P62508	Estrogen-related receptor gamma	ITCH	82:85	PPLY	ITCH,NEDD4	0.9981	More...
Q99958	Forkhead box protein C2	ITCH	485:488	PPLY	ITCH,NEDD4	0.9946	More...
Q9P0K8	Forkhead box protein J2	ITCH	230:233	PPLY	ITCH,NEDD4	0.8417	More...
Q2KHR3	Glutamine and serine-rich protein 1	ITCH	370:373	PPLY	ITCH,NEDD4	0.8458	More...
Q9H0J4	Glutamine-rich protein 2	ITCH	1404:1407	PPLY	ITCH,NEDD4	0.9172	More...
Q96CC6	Inactive rhomboid protein 1	ITCH	141:144	PPLY	ITCH,NEDD4	0.9927	More...
Q8NDH2	Leucine-rich repeat transmembrane protein CCDC168	ITCH	5560:5563	PPLY	ITCH,NEDD4	0.6888	More...
Q9P2G4	Microtubule-associated protein 10	ITCH	302:305	PPLY	ITCH,NEDD4	0.9678	More...
Q9HB07	MYG1 exonuclease	ITCH	17:20	PPLY	ITCH,NEDD4	0.6345	More...
Q02080	Myocyte-specific enhancer factor 2B	ITCH	198:201	PPLY	ITCH,NEDD4	0.992	More...
Q5VTT5	Myomesin-3	ITCH	824:827	PPLY	ITCH,NEDD4	0.901	More...

Showing 1 to 25 of 51 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPLY

Degron related mutations and impact score

Drug responses associated with RBBP6 mutations

All proteins holding degron of PPLY