DegronMD - O95429(BAG4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L334I	TCGA-AA-3977	COAD	TCGA	DSQVQYSAEP	CBL_PTK	336:345	Mutation rewiring degron network	0.2778
p.L334I	DO8730	COAD	ICGC	DSQVQYSAEP	CBL_PTK	336:345	Mutation rewiring degron network	0.2778
p.L334I	SIDM01182	Bladder Carcinoma	GDSC	DSQVQYSAEP	CBL_PTK	336:345	Mutation rewiring degron network	0.2778
p.L334I	ACH-000522	Bladder Cancer	CCLE	DSQVQYSAEP	CBL_PTK	336:345	Mutation rewiring degron network	0.2778
p.L334I	UM-UC-3	urinary tract	COSMIC	DSQVQYSAEP	CBL_PTK	336:345	Mutation rewiring degron network	0.2778
p.P33L	TCGA-B5-A3FC	UCEC	TCGA	PPLY	ITCH	34:37	Mutation rewiring degron network	0.3056
p.P33L	DO41871	UCEC	ICGC	PPLY	ITCH	34:37	Mutation rewiring degron network	0.3056
p.D333H	TCGA-CV-7090	HNSC	TCGA	DSQVQYSAEP	CBL_PTK	336:345	Mutation rewiring degron network	0.25
p.D333H	DO14238	HNSC	ICGC	DSQVQYSAEP	CBL_PTK	336:345	Mutation rewiring degron network	0.25
p.P345S	TCGA-EO-A3B0	UCEC	TCGA	DSQVQYSAEP	CBL_PTK	336:345	Mutation altering degron motif	0.6752
p.P345S	DO219773	UCEC	ICGC	DSQVQYSAEP	CBL_PTK	336:345	Mutation altering degron motif	0.6752
p.H355Y	TCGA-QK-AA3J	HNSC	TCGA	DSQVQYSAEP	CBL_PTK	336:345	Mutation rewiring degron network	0.0556
p.H355Y	DO52101	HNSC	ICGC	DSQVQYSAEP	CBL_PTK	336:345	Mutation rewiring degron network	0.0556
p.E344D	DO229025	LICA	ICGC	DSQVQYSAEP	CBL_PTK	336:345	Mutation altering degron motif	0.5647
p.G25S	SIDM00156	Neuroblastoma	GDSC	PPLY	ITCH	34:37	Mutation rewiring degron network	0.0833
p.G25S	SIDM01097	Other Solid Cancers	GDSC	PPLY	ITCH	34:37	Mutation rewiring degron network	0.0833
p.G25S	SIDM01229	Neuroblastoma	GDSC	PPLY	ITCH	34:37	Mutation rewiring degron network	0.0833

Kaplan plot for BAG4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BAG4

UniProt ID: O95429

Entrez ID: 9530

Protein name: BAG family molecular chaperone regulator 4 (BAG-4) (Bcl-2-associated athanogene 4) (Silencer of death domains)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BAG4 in