DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DSQVQYSAEP
Uniprot ID:
O95429
Source protein:
BAG family molecular chaperone regulator 4
Source gene:
BAG4
Class:
CBL_PTK
Location:
336:345
E3 ligase:
CBL
DEGRON score:
0.6767
ASA_SCORE:
96.64
COIL:
0.9077
CONS_SCORE:
0.6192
DSS_SCORE:
0.6376
HELIX:
0.0539
FCONS_SCORE:
1.2384
RIG_SCORE:
0.7389
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.L334I
TCGA-AA-3977
COAD
TCGA
DSQVQYSAEP
CBL_PTK
0.2778
p.L334I
DO8730
COAD
ICGC
DSQVQYSAEP
CBL_PTK
0.2778
p.L334I
SIDM01182
Bladder Carcinoma
GDSC
DSQVQYSAEP
CBL_PTK
0.2778
p.L334I
ACH-000522
Bladder Cancer
CCLE
DSQVQYSAEP
CBL_PTK
0.2778
p.L334I
UM-UC-3
urinary_tract
COSMIC
DSQVQYSAEP
CBL_PTK
0.2778
p.D333H
TCGA-CV-7090
HNSC
TCGA
DSQVQYSAEP
CBL_PTK
0.25
p.D333H
DO14238
HNSC
ICGC
DSQVQYSAEP
CBL_PTK
0.25
p.P345S
TCGA-EO-A3B0
UCEC
TCGA
DSQVQYSAEP
CBL_PTK
0.6752
p.P345S
DO219773
UCEC
ICGC
DSQVQYSAEP
CBL_PTK
0.6752
p.H355Y
TCGA-QK-AA3J
HNSC
TCGA
DSQVQYSAEP
CBL_PTK
0.0556
p.H355Y
DO52101
HNSC
ICGC
DSQVQYSAEP
CBL_PTK
0.0556
p.E344D
DO229025
LICA
ICGC
DSQVQYSAEP
CBL_PTK
0.5647
Drug responses associated with BAG4 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSQVQYSAEP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O95429
BAG family molecular chaperone regulator 4
CBL_PTK
336:345
DSQVQYSAEP
CBL
0.6767
More...
