DegronMD - Q96CC6(RHBDF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E138K	TCGA-D1-A167	UCEC	TCGA	PPLY	ITCH	141:144	Mutation rewiring degron network	0.25
p.E138K	DO40978	UCEC	ICGC	PPLY	ITCH	141:144	Mutation rewiring degron network	0.25
p.G146W	TCGA-D3-A2JC	SKCM	TCGA	PPLY	ITCH	141:144	Mutation rewiring degron network	0.2778
p.G146W	DO47578	SKCM	ICGC	PPLY	ITCH	141:144	Mutation rewiring degron network	0.2778
p.V422M	TCGA-EY-A2OM	UCEC	TCGA	FFTYWLTFV	DEG_MDM2_SWIB_1	405:413	Mutation rewiring degron network	0.0833
p.V422M	DO43025	UCEC	ICGC	FFTYWLTFV	DEG_MDM2_SWIB_1	405:413	Mutation rewiring degron network	0.0833
p.V422M	SIDM00958	Chronic Myelogenous Leukemia	GDSC	FFTYWLTFV	DEG_MDM2_SWIB_1	405:413	Mutation rewiring degron network	0.0833
p.V422M	ACH-000920	Leukemia	CCLE	FFTYWLTFV	DEG_MDM2_SWIB_1	405:413	Mutation rewiring degron network	0.0833
p.V422M	CML-T1	haematopoietic and lymphoid tissue	COSMIC	FFTYWLTFV	DEG_MDM2_SWIB_1	405:413	Mutation rewiring degron network	0.0833
p.P141L	TCGA-FS-A1Z3	SKCM	TCGA	PPLY	ITCH	141:144	Mutation altering degron motif	0.7582
p.P141L	DO37635	SKCM	ICGC	PPLY	ITCH	141:144	Mutation altering degron motif	0.7582
p.V417L	TCGA-FW-A3TV	SKCM	TCGA	FFTYWLTFV	DEG_MDM2_SWIB_1	405:413	Mutation rewiring degron network	0.2222
p.V417L	DO38159	SKCM	ICGC	FFTYWLTFV	DEG_MDM2_SWIB_1	405:413	Mutation rewiring degron network	0.2222
p.T139M	TCGA-S9-A6UA	LGG	TCGA	PPLY	ITCH	141:144	Mutation rewiring degron network	0.2778
p.T139M	DO50193	LGG	ICGC	PPLY	ITCH	141:144	Mutation rewiring degron network	0.2778
p.P142S	TCGA-WE-A8ZT	SKCM	TCGA	PPLY	ITCH	141:144	Mutation altering degron motif	0.6752
p.P142S	DO51290	SKCM	ICGC	PPLY	ITCH	141:144	Mutation altering degron motif	0.6752
p.P140S	DO230343	COCA	ICGC	PPLY	ITCH	141:144	Mutation rewiring degron network	0.3056
p.L134M	DO228948	LICA	ICGC	PPLY	ITCH	141:144	Mutation rewiring degron network	0.1389
p.D400E	DO229029	LICA	ICGC	FFTYWLTFV	DEG_MDM2_SWIB_1	405:413	Mutation rewiring degron network	0.1944
p.D400G	DO41199	UCEC	ICGC	FFTYWLTFV	DEG_MDM2_SWIB_1	405:413	Mutation rewiring degron network	0.1944
p.W409R	SIDM00675	Breast Carcinoma	GDSC	FFTYWLTFV	DEG_MDM2_SWIB_1	405:413	Mutation altering degron motif	0.8634
p.W409R	ACH-000276	Breast Cancer	CCLE	FFTYWLTFV	DEG_MDM2_SWIB_1	405:413	Mutation altering degron motif	0.8634
p.W409R	HCC38	breast	COSMIC	FFTYWLTFV	DEG_MDM2_SWIB_1	405:413	Mutation altering degron motif	0.8634
p.S136N	SIDM01187	Breast Carcinoma	GDSC	PPLY	ITCH	141:144	Mutation rewiring degron network	0.1944
p.S136N	ACH-000568	Breast Cancer	CCLE	PPLY	ITCH	141:144	Mutation rewiring degron network	0.1944
p.S136N	UACC-812	breast	COSMIC	PPLY	ITCH	141:144	Mutation rewiring degron network	0.1944
p.E397K	SIDM01424	B-Lymphoblastic Leukemia	GDSC	FFTYWLTFV	DEG_MDM2_SWIB_1	405:413	Mutation rewiring degron network	0.1111
p.E397K	ACH-000782	Leukemia	CCLE	FFTYWLTFV	DEG_MDM2_SWIB_1	405:413	Mutation rewiring degron network	0.1111
p.E397K	ACH-001735	Leukemia	CCLE	FFTYWLTFV	DEG_MDM2_SWIB_1	405:413	Mutation rewiring degron network	0.1111
p.M399I	ACH-000554	Breast Cancer	CCLE	FFTYWLTFV	DEG_MDM2_SWIB_1	405:413	Mutation rewiring degron network	0.1667

Kaplan plot for RHBDF1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RHBDF1

UniProt ID: Q96CC6

Entrez ID: 64285

Protein name: Inactive rhomboid protein 1 (iRhom1) (Epidermal growth factor receptor-related protein) (Rhomboid 5 homolog 1) (Rhomboid family member 1) (p100hRho)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RHBDF1 in