DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
FFTYWLTFV
Uniprot ID:
Q96CC6
Source protein:
Inactive rhomboid protein 1
Source gene:
RHBDF1
Class:
DEG_MDM2_SWIB_1
Location:
405:413
E3 ligase:
MDM2
DEGRON score:
0.5292
ASA_SCORE:
43.9222
COIL:
0.0168
CONS_SCORE:
0.5918
DSS_SCORE:
0.0075
HELIX:
0.9752
FCONS_SCORE:
1.2787
RIG_SCORE:
1.0015
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.V422M
TCGA-EY-A2OM
UCEC
TCGA
FFTYWLTFV
DEG_MDM2_SWIB_1
0.0833
p.V422M
DO43025
UCEC
ICGC
FFTYWLTFV
DEG_MDM2_SWIB_1
0.0833
p.V422M
SIDM00958
Chronic Myelogenous Leukemia
GDSC
FFTYWLTFV
DEG_MDM2_SWIB_1
0.0833
p.V422M
ACH-000920
Leukemia
CCLE
FFTYWLTFV
DEG_MDM2_SWIB_1
0.0833
p.V422M
CML-T1
haematopoietic_and_lymphoid_tissue
COSMIC
FFTYWLTFV
DEG_MDM2_SWIB_1
0.0833
p.V417L
TCGA-FW-A3TV
SKCM
TCGA
FFTYWLTFV
DEG_MDM2_SWIB_1
0.2222
p.V417L
DO38159
SKCM
ICGC
FFTYWLTFV
DEG_MDM2_SWIB_1
0.2222
p.D400E
DO229029
LICA
ICGC
FFTYWLTFV
DEG_MDM2_SWIB_1
0.1944
p.D400G
DO41199
UCEC
ICGC
FFTYWLTFV
DEG_MDM2_SWIB_1
0.1944
p.W409R
SIDM00675
Breast Carcinoma
GDSC
FFTYWLTFV
DEG_MDM2_SWIB_1
0.8634
p.W409R
ACH-000276
Breast Cancer
CCLE
FFTYWLTFV
DEG_MDM2_SWIB_1
0.8634
p.W409R
HCC38
breast
COSMIC
FFTYWLTFV
DEG_MDM2_SWIB_1
0.8634
p.E397K
SIDM01424
B-Lymphoblastic Leukemia
GDSC
FFTYWLTFV
DEG_MDM2_SWIB_1
0.1111
p.E397K
ACH-000782
Leukemia
CCLE
FFTYWLTFV
DEG_MDM2_SWIB_1
0.1111
p.E397K
ACH-001735
Leukemia
CCLE
FFTYWLTFV
DEG_MDM2_SWIB_1
0.1111
p.M399I
ACH-000554
Breast Cancer
CCLE
FFTYWLTFV
DEG_MDM2_SWIB_1
0.1667
Drug responses associated with RHBDF1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of FFTYWLTFV
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96CC6
Inactive rhomboid protein 1
DEG_MDM2_SWIB_1
405:413
FFTYWLTFV
MDM2
0.5292
More...