DegronMD

Uniprot ID: Q96CC6

Source protein: Inactive rhomboid protein 1

Source gene: RHBDF1

Class: DEG_MDM2_SWIB_1

Location: 405:413

E3 ligase: MDM2

DEGRON score: 0.5292

ASA_SCORE: 43.9222

COIL: 0.0168

CONS_SCORE: 0.5918

DSS_SCORE: 0.0075

HELIX: 0.9752

FCONS_SCORE: 1.2787

RIG_SCORE: 1.0015

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W409R	SIDM00675	Breast Carcinoma	GDSC	FFTYWLTFV	DEG_MDM2_SWIB_1	0.8634
p.W409R	ACH-000276	Breast Cancer	CCLE	FFTYWLTFV	DEG_MDM2_SWIB_1	0.8634
p.W409R	HCC38	breast	COSMIC	FFTYWLTFV	DEG_MDM2_SWIB_1	0.8634
p.V417L	TCGA-FW-A3TV	SKCM	TCGA	FFTYWLTFV	DEG_MDM2_SWIB_1	0.2222
p.V417L	DO38159	SKCM	ICGC	FFTYWLTFV	DEG_MDM2_SWIB_1	0.2222
p.D400E	DO229029	LICA	ICGC	FFTYWLTFV	DEG_MDM2_SWIB_1	0.1944
p.D400G	DO41199	UCEC	ICGC	FFTYWLTFV	DEG_MDM2_SWIB_1	0.1944
p.M399I	ACH-000554	Breast Cancer	CCLE	FFTYWLTFV	DEG_MDM2_SWIB_1	0.1667
p.E397K	SIDM01424	B-Lymphoblastic Leukemia	GDSC	FFTYWLTFV	DEG_MDM2_SWIB_1	0.1111
p.E397K	ACH-000782	Leukemia	CCLE	FFTYWLTFV	DEG_MDM2_SWIB_1	0.1111
p.E397K	ACH-001735	Leukemia	CCLE	FFTYWLTFV	DEG_MDM2_SWIB_1	0.1111
p.V422M	TCGA-EY-A2OM	UCEC	TCGA	FFTYWLTFV	DEG_MDM2_SWIB_1	0.0833
p.V422M	DO43025	UCEC	ICGC	FFTYWLTFV	DEG_MDM2_SWIB_1	0.0833
p.V422M	SIDM00958	Chronic Myelogenous Leukemia	GDSC	FFTYWLTFV	DEG_MDM2_SWIB_1	0.0833
p.V422M	ACH-000920	Leukemia	CCLE	FFTYWLTFV	DEG_MDM2_SWIB_1	0.0833
p.V422M	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	FFTYWLTFV	DEG_MDM2_SWIB_1	0.0833

Showing 1 to 16 of 16 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96CC6	Inactive rhomboid protein 1	DEG_MDM2_SWIB_1	405:413	FFTYWLTFV	MDM2	0.5292	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons