DegronMD - Q13443(ADAM9)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R807H	TCGA-34-2596	LUSC	TCGA	PPLY	ITCH	812:815	Mutation rewiring degron network	0.1944
p.R807H	DO26508	LUSC	ICGC	PPLY	ITCH	812:815	Mutation rewiring degron network	0.1944
p.P750L	TCGA-D1-A17M	UCEC	TCGA	PVTPPRE	DEG_SCF_FBW7_2	759:765	Mutation rewiring degron network	0.0833
p.P750L	DO43779	UCEC	ICGC	PVTPPRE	DEG_SCF_FBW7_2	759:765	Mutation rewiring degron network	0.0833
p.P750L	SIDM00493	Other Solid Cancers	GDSC	PVTPPRE	DEG_SCF_FBW7_2	759:765	Mutation rewiring degron network	0.0833
p.I768V	TCGA-E7-A85H	BLCA	TCGA	PVTPPRE	DEG_SCF_FBW7_2	759:765	Mutation rewiring degron network	0.25
p.I768V	DO219018	BLCA	ICGC	PVTPPRE	DEG_SCF_FBW7_2	759:765	Mutation rewiring degron network	0.25
p.R755L	TCGA-EA-A1QS	CESC	TCGA	PVTPPRE	DEG_SCF_FBW7_2	759:765	Mutation rewiring degron network	0.2222
p.R755L	DO48990	CESC	ICGC	PVTPPRE	DEG_SCF_FBW7_2	759:765	Mutation rewiring degron network	0.2222
p.V766A	TCGA-WE-A8K4	SKCM	TCGA	PVTPPRE	DEG_SCF_FBW7_2	759:765	Mutation rewiring degron network	0.3056
p.V766A	DO51281	SKCM	ICGC	PVTPPRE	DEG_SCF_FBW7_2	759:765	Mutation rewiring degron network	0.3056
p.E765K	DO225015	BRCA	ICGC	PVTPPRE	DEG_SCF_FBW7_2	759:765	Mutation altering degron motif	0.7022
p.E765K	DO52558	BRCA	ICGC	PVTPPRE	DEG_SCF_FBW7_2	759:765	Mutation altering degron motif	0.7022
p.E765D	DO234333	ESAD	ICGC	PVTPPRE	DEG_SCF_FBW7_2	759:765	Mutation altering degron motif	0.6758
p.V766F	DO229029	LICA	ICGC	PVTPPRE	DEG_SCF_FBW7_2	759:765	Mutation rewiring degron network	0.3056
p.P813S	SIDM00545	Melanoma	GDSC	PPLY	ITCH	812:815	Mutation altering degron motif	0.6752
p.P813S	SIDM00190	Melanoma	GDSC	PPLY	ITCH	812:815	Mutation altering degron motif	0.6752
p.P813S	ACH-000987	Skin Cancer	CCLE	PPLY	ITCH	812:815	Mutation altering degron motif	0.6752
p.P813S	ACH-002097	Skin Cancer	CCLE	PPLY	ITCH	812:815	Mutation altering degron motif	0.6752
p.P813S	CP66-MEL	skin	COSMIC	PPLY	ITCH	812:815	Mutation altering degron motif	0.6752
p.P813S	Mewo	skin	COSMIC	PPLY	ITCH	812:815	Mutation altering degron motif	0.6752
p.R772T	ACH-000467	Colon/Colorectal Cancer	CCLE	PVTPPRE	DEG_SCF_FBW7_2	759:765	Mutation rewiring degron network	0.1389
p.R772T	HCC-56	large intestine	COSMIC	PVTPPRE	DEG_SCF_FBW7_2	759:765	Mutation rewiring degron network	0.1389
p.R772K	ACH-001408	Bladder Cancer	CCLE	PVTPPRE	DEG_SCF_FBW7_2	759:765	Mutation rewiring degron network	0.1389

Kaplan plot for ADAM9 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ADAM9

UniProt ID: Q13443

Entrez ID: 8754

Protein name: Disintegrin and metalloproteinase domain-containing protein 9 (ADAM 9) (EC 3.4.24.-) (Cellular disintegrin-related protein) (Meltrin-gamma) (Metalloprotease/disintegrin/cysteine-rich protein 9) (Myeloma cell metalloproteinase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ADAM9 in