DegronMD

Uniprot ID: Q13443

Source protein: Disintegrin and metalloproteinase domain-containing protein 9

Source gene: ADAM9

Class: DEG_SCF_FBW7_2

Location: 759:765

E3 ligase: FBXW7

DEGRON score: 0.9952

ASA_SCORE: 111.8

COIL: 0.9754

CONS_SCORE: 0.47

DSS_SCORE: 0.5783

HELIX: 0.0109

FCONS_SCORE: 1.1044

RIG_SCORE: 0.6492

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P750L	TCGA-D1-A17M	UCEC	TCGA	PVTPPRE	DEG_SCF_FBW7_2	0.0833
p.P750L	DO43779	UCEC	ICGC	PVTPPRE	DEG_SCF_FBW7_2	0.0833
p.P750L	SIDM00493	Other Solid Cancers	GDSC	PVTPPRE	DEG_SCF_FBW7_2	0.0833
p.I768V	TCGA-E7-A85H	BLCA	TCGA	PVTPPRE	DEG_SCF_FBW7_2	0.25
p.I768V	DO219018	BLCA	ICGC	PVTPPRE	DEG_SCF_FBW7_2	0.25
p.R755L	TCGA-EA-A1QS	CESC	TCGA	PVTPPRE	DEG_SCF_FBW7_2	0.2222
p.R755L	DO48990	CESC	ICGC	PVTPPRE	DEG_SCF_FBW7_2	0.2222
p.V766A	TCGA-WE-A8K4	SKCM	TCGA	PVTPPRE	DEG_SCF_FBW7_2	0.3056
p.V766A	DO51281	SKCM	ICGC	PVTPPRE	DEG_SCF_FBW7_2	0.3056
p.E765K	DO225015	BRCA	ICGC	PVTPPRE	DEG_SCF_FBW7_2	0.7022
p.E765K	DO52558	BRCA	ICGC	PVTPPRE	DEG_SCF_FBW7_2	0.7022
p.E765D	DO234333	ESAD	ICGC	PVTPPRE	DEG_SCF_FBW7_2	0.6758
p.V766F	DO229029	LICA	ICGC	PVTPPRE	DEG_SCF_FBW7_2	0.3056
p.R772T	ACH-000467	Colon/Colorectal Cancer	CCLE	PVTPPRE	DEG_SCF_FBW7_2	0.1389
p.R772T	HCC-56	large_intestine	COSMIC	PVTPPRE	DEG_SCF_FBW7_2	0.1389
p.R772K	ACH-001408	Bladder Cancer	CCLE	PVTPPRE	DEG_SCF_FBW7_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13443	Disintegrin and metalloproteinase domain-containing protein 9	DEG_SCF_FBW7_2	759:765	PVTPPRE	FBXW7	0.9952	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons