DegronMD - Q86XL3(ANKLE2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A190E	TCGA-04-1360	OV	TCGA	PPLY	ITCH	196:199	Mutation rewiring degron network	0.1667
p.A190E	DO29628	OV	ICGC	PPLY	ITCH	196:199	Mutation rewiring degron network	0.1667
p.Q761H	TCGA-13-0890	OV	TCGA	VSKTPDES	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.1667
p.Q761P	TCGA-13-0890	OV	TCGA	VSKTPDES	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.1667
p.E815V	TCGA-33-6738	LUSC	TCGA	LFLFGE	LIG_APCC_ABBA_1	824:829	Mutation rewiring degron network	0.0833
p.E815V	TCGA-33-6738	LUSC	TCGA	RLFLFGE	LIG_APCC_ABBAyCdc20_2	823:829	Mutation rewiring degron network	0.1111
p.E533K	TCGA-66-2771	LUSC	TCGA	LWKTPPRE	DEG_SCF_FBW7_2	538:545	Mutation rewiring degron network	0.1944
p.E533K	DO26870	LUSC	ICGC	LWKTPPRE	DEG_SCF_FBW7_2	538:545	Mutation rewiring degron network	0.1944
p.D753H	TCGA-A7-A26H	BRCA	TCGA	VSKTPDES	DEG_SCF_FBW7_1	748:755	Mutation altering degron motif	0.6577
p.D534N	TCGA-A7-A56D	BRCA	TCGA	LWKTPPRE	DEG_SCF_FBW7_2	538:545	Mutation rewiring degron network	0.2222
p.D534N	DO44165	BRCA	ICGC	LWKTPPRE	DEG_SCF_FBW7_2	538:545	Mutation rewiring degron network	0.2222
p.R536H	TCGA-AD-6889	COAD	TCGA	LWKTPPRE	DEG_SCF_FBW7_2	538:545	Mutation rewiring degron network	0.2778
p.R536H	DO8463	COAD	ICGC	LWKTPPRE	DEG_SCF_FBW7_2	538:545	Mutation rewiring degron network	0.2778
p.R746H	TCGA-AJ-A8CT	UCEC	TCGA	VSKTPDES	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.2778
p.R746H	TCGA-HU-A4H4	STAD	TCGA	VSKTPDES	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.2778
p.R746H	SIDM00251	Gastric Carcinoma	GDSC	VSKTPDES	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.2778
p.R746H	TGBC11TKB	stomach	COSMIC	VSKTPDES	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.2778
p.R536C	TCGA-AP-A0LM	UCEC	TCGA	LWKTPPRE	DEG_SCF_FBW7_2	538:545	Mutation rewiring degron network	0.2778
p.R536C	TCGA-DK-A6AW	BLCA	TCGA	LWKTPPRE	DEG_SCF_FBW7_2	538:545	Mutation rewiring degron network	0.2778
p.R536C	DO48566	BLCA	ICGC	LWKTPPRE	DEG_SCF_FBW7_2	538:545	Mutation rewiring degron network	0.2778
p.R536C	DO220877	MELA	ICGC	LWKTPPRE	DEG_SCF_FBW7_2	538:545	Mutation rewiring degron network	0.2778
p.R536C	DO43306	UCEC	ICGC	LWKTPPRE	DEG_SCF_FBW7_2	538:545	Mutation rewiring degron network	0.2778
p.R536C	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	LWKTPPRE	DEG_SCF_FBW7_2	538:545	Mutation rewiring degron network	0.2778
p.R536C	ACH-000809	Esophageal Cancer	CCLE	LWKTPPRE	DEG_SCF_FBW7_2	538:545	Mutation rewiring degron network	0.2778
p.R536C	KYSE-410	oesophagus	COSMIC	LWKTPPRE	DEG_SCF_FBW7_2	538:545	Mutation rewiring degron network	0.2778
p.K537R	TCGA-AR-A1AV	BRCA	TCGA	LWKTPPRE	DEG_SCF_FBW7_2	538:545	Mutation rewiring degron network	0.3056
p.K537R	DO4659	BRCA	ICGC	LWKTPPRE	DEG_SCF_FBW7_2	538:545	Mutation rewiring degron network	0.3056
p.A547T	TCGA-AX-A06F	UCEC	TCGA	LWKTPPRE	DEG_SCF_FBW7_2	538:545	Mutation rewiring degron network	0.2778
p.A547T	DO41752	UCEC	ICGC	LWKTPPRE	DEG_SCF_FBW7_2	538:545	Mutation rewiring degron network	0.2778
p.A192V	TCGA-AX-A1CE	UCEC	TCGA	PPLY	ITCH	196:199	Mutation rewiring degron network	0.2222
p.A192V	TCGA-KQ-A41Q	BLCA	TCGA	PPLY	ITCH	196:199	Mutation rewiring degron network	0.2222
p.A192V	DO223591	BLCA	ICGC	PPLY	ITCH	196:199	Mutation rewiring degron network	0.2222
p.A192V	DO42280	UCEC	ICGC	PPLY	ITCH	196:199	Mutation rewiring degron network	0.2222
p.R187K	TCGA-B8-A8YJ	KIRC	TCGA	PPLY	ITCH	196:199	Mutation rewiring degron network	0.0833
p.E815Q	TCGA-BA-4077	HNSC	TCGA	LFLFGE	LIG_APCC_ABBA_1	824:829	Mutation rewiring degron network	0.0833
p.E815Q	TCGA-BA-4077	HNSC	TCGA	RLFLFGE	LIG_APCC_ABBAyCdc20_2	823:829	Mutation rewiring degron network	0.1111
p.Y199H	TCGA-BR-8360	STAD	TCGA	PPLY	ITCH	196:199	Mutation altering degron motif	0.834
p.Y199H	DO47745	STAD	ICGC	PPLY	ITCH	196:199	Mutation altering degron motif	0.834
p.K537T	TCGA-BR-8591	STAD	TCGA	LWKTPPRE	DEG_SCF_FBW7_2	538:545	Mutation rewiring degron network	0.3056
p.K537T	DO47973	STAD	ICGC	LWKTPPRE	DEG_SCF_FBW7_2	538:545	Mutation rewiring degron network	0.3056
p.L550F	TCGA-EE-A29R	SKCM	TCGA	LWKTPPRE	DEG_SCF_FBW7_2	538:545	Mutation rewiring degron network	0.1944
p.L550F	DO37448	SKCM	ICGC	LWKTPPRE	DEG_SCF_FBW7_2	538:545	Mutation rewiring degron network	0.1944
p.L739R	TCGA-GN-A8LK	SKCM	TCGA	VSKTPDES	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.0833
p.G828E	TCGA-MA-AA42	CESC	TCGA	LFLFGE	LIG_APCC_ABBA_1	824:829	Mutation altering degron motif	0.6087
p.G828E	TCGA-MA-AA42	CESC	TCGA	RLFLFGE	LIG_APCC_ABBAyCdc20_2	823:829	Mutation altering degron motif	0.6087
p.R746C	TCGA-QG-A5Z2	COAD	TCGA	VSKTPDES	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.2778
p.R746C	OV-17R	ovary	COSMIC	VSKTPDES	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.2778
p.D203N	DO225190	BRCA	ICGC	PPLY	ITCH	196:199	Mutation rewiring degron network	0.2222
p.D203N	DO227561	BRCA	ICGC	PPLY	ITCH	196:199	Mutation rewiring degron network	0.2222
p.A547E	DO229015	LICA	ICGC	LWKTPPRE	DEG_SCF_FBW7_2	538:545	Mutation rewiring degron network	0.2778
p.P208Q	DO229029	LICA	ICGC	PPLY	ITCH	196:199	Mutation rewiring degron network	0.0833
p.A200E	DO229029	LICA	ICGC	PPLY	ITCH	196:199	Mutation blocking phosphorylation signal	0.75
p.K537N	DO45127	LIRI	ICGC	LWKTPPRE	DEG_SCF_FBW7_2	538:545	Mutation rewiring degron network	0.3056
p.P204T	DO229253	THCA	ICGC	PPLY	ITCH	196:199	Mutation rewiring degron network	0.1944
p.F207L	DO41871	UCEC	ICGC	PPLY	ITCH	196:199	Mutation rewiring degron network	0.1111
p.V202I	DO41337	UCEC	ICGC	PPLY	ITCH	196:199	Mutation rewiring degron network	0.25
p.T191A	SIDM02039	Colorectal Carcinoma	GDSC	PPLY	ITCH	196:199	Mutation blocking phosphorylation signal	0.6389
p.C203F	SIDM00491	Thyroid Gland Carcinoma	GDSC	PPLY	ITCH	196:199	Mutation rewiring degron network	0.2222
p.C203F	ACH-001443	Thyroid Cancer	CCLE	PPLY	ITCH	196:199	Mutation rewiring degron network	0.2222
p.C203F	ASH-3	thyroid	COSMIC	PPLY	ITCH	196:199	Mutation rewiring degron network	0.2222
p.S747G	SIDM00899	Pancreatic Carcinoma	GDSC	VSKTPDES	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.3056
p.S747G	AsPC-1	pancreas	COSMIC	VSKTPDES	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.3056
p.R822T	SIDM00875	Breast Carcinoma	GDSC	LFLFGE	LIG_APCC_ABBA_1	824:829	Mutation rewiring degron network	0.2778
p.R822T	SIDM00875	Breast Carcinoma	GDSC	RLFLFGE	LIG_APCC_ABBAyCdc20_2	823:829	Mutation rewiring degron network	0.3056
p.R822T	HCC1806	breast	COSMIC	LFLFGE	LIG_APCC_ABBA_1	824:829	Mutation rewiring degron network	0.2778
p.R822T	HCC1806	breast	COSMIC	RLFLFGE	LIG_APCC_ABBAyCdc20_2	823:829	Mutation rewiring degron network	0.3056
p.S749C	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	VSKTPDES	DEG_SCF_FBW7_1	748:755	Mutation altering degron motif	0.643
p.S749C	NCI-H2009	lung	COSMIC	VSKTPDES	DEG_SCF_FBW7_1	748:755	Mutation altering degron motif	0.643
p.H551Y	SIDM01695	Acute Myeloid Leukemia	GDSC	LWKTPPRE	DEG_SCF_FBW7_2	538:545	Mutation rewiring degron network	0.1667
p.H551Y	ACH-000166	Leukemia	CCLE	LWKTPPRE	DEG_SCF_FBW7_2	538:545	Mutation rewiring degron network	0.1667
p.L197V	ACH-001329	Brain Cancer	CCLE	PPLY	ITCH	196:199	Mutation altering degron motif	0.6765

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ANKLE2

UniProt ID: Q86XL3

Entrez ID: 23141

Protein name: Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ANKLE2 in