DegronMD

Uniprot ID: Q86XL3

Source protein: Ankyrin repeat and LEM domain-containing protein 2

Source gene: ANKLE2

Class: LIG_APCC_ABBAyCdc20_2

Location: 823:829

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7291

ASA_SCORE: 56.8571

COIL: 0.5659

CONS_SCORE: 0.5144

DSS_SCORE: 0.4191

HELIX: 0.114

FCONS_SCORE: 1.1717

RIG_SCORE: 0.775

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E815V	TCGA-33-6738	LUSC	TCGA	RLFLFGE	LIG_APCC_ABBAyCdc20_2	0.1111
p.E815Q	TCGA-BA-4077	HNSC	TCGA	RLFLFGE	LIG_APCC_ABBAyCdc20_2	0.1111
p.G828E	TCGA-MA-AA42	CESC	TCGA	RLFLFGE	LIG_APCC_ABBAyCdc20_2	0.6087
p.R822T	SIDM00875	Breast Carcinoma	GDSC	RLFLFGE	LIG_APCC_ABBAyCdc20_2	0.3056
p.R822T	HCC1806	breast	COSMIC	RLFLFGE	LIG_APCC_ABBAyCdc20_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86XL3	Ankyrin repeat and LEM domain-containing protein 2	LIG_APCC_ABBAyCdc20_2	823:829	RLFLFGE	APC,CDC20,FZR1	0.7291	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons