DegronMD

Uniprot ID: Q86XL3

Source protein: Ankyrin repeat and LEM domain-containing protein 2

Source gene: ANKLE2

Class: DEG_SCF_FBW7_1

Location: 748:755

E3 ligase: FBXW7

DEGRON score: 0.5823

ASA_SCORE: 84.55

COIL: 0.7029

CONS_SCORE: 0.3336

DSS_SCORE: 0.5804

HELIX: 0.2505

FCONS_SCORE: 0.9497

RIG_SCORE: 0.6731

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q761H	TCGA-13-0890	OV	TCGA	VSKTPDES	DEG_SCF_FBW7_1	0.1667
p.Q761P	TCGA-13-0890	OV	TCGA	VSKTPDES	DEG_SCF_FBW7_1	0.1667
p.D753H	TCGA-A7-A26H	BRCA	TCGA	VSKTPDES	DEG_SCF_FBW7_1	0.6577
p.R746H	TCGA-AJ-A8CT	UCEC	TCGA	VSKTPDES	DEG_SCF_FBW7_1	0.2778
p.R746H	TCGA-HU-A4H4	STAD	TCGA	VSKTPDES	DEG_SCF_FBW7_1	0.2778
p.R746H	SIDM00251	Gastric Carcinoma	GDSC	VSKTPDES	DEG_SCF_FBW7_1	0.2778
p.R746H	TGBC11TKB	stomach	COSMIC	VSKTPDES	DEG_SCF_FBW7_1	0.2778
p.L739R	TCGA-GN-A8LK	SKCM	TCGA	VSKTPDES	DEG_SCF_FBW7_1	0.0833
p.R746C	TCGA-QG-A5Z2	COAD	TCGA	VSKTPDES	DEG_SCF_FBW7_1	0.2778
p.R746C	OV-17R	ovary	COSMIC	VSKTPDES	DEG_SCF_FBW7_1	0.2778
p.S747G	SIDM00899	Pancreatic Carcinoma	GDSC	VSKTPDES	DEG_SCF_FBW7_1	0.3056
p.S747G	AsPC-1	pancreas	COSMIC	VSKTPDES	DEG_SCF_FBW7_1	0.3056
p.S749C	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	VSKTPDES	DEG_SCF_FBW7_1	0.643
p.S749C	NCI-H2009	lung	COSMIC	VSKTPDES	DEG_SCF_FBW7_1	0.643

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86XL3	Ankyrin repeat and LEM domain-containing protein 2	DEG_SCF_FBW7_1	748:755	VSKTPDES	FBXW7	0.5823	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons