DegronMD

Uniprot ID: Q86XL3

Source protein: Ankyrin repeat and LEM domain-containing protein 2

Source gene: ANKLE2

Class: LIG_APCC_ABBA_1

Location: 824:829

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.852

ASA_SCORE: 51.4667

COIL: 0.5993

CONS_SCORE: 0.5374

DSS_SCORE: 0.4138

HELIX: 0.0872

FCONS_SCORE: 1.2201

RIG_SCORE: 0.7716

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G828E	TCGA-MA-AA42	CESC	TCGA	LFLFGE	LIG_APCC_ABBA_1	0.6087
p.R822T	SIDM00875	Breast Carcinoma	GDSC	LFLFGE	LIG_APCC_ABBA_1	0.2778
p.R822T	HCC1806	breast	COSMIC	LFLFGE	LIG_APCC_ABBA_1	0.2778
p.E815V	TCGA-33-6738	LUSC	TCGA	LFLFGE	LIG_APCC_ABBA_1	0.0833
p.E815Q	TCGA-BA-4077	HNSC	TCGA	LFLFGE	LIG_APCC_ABBA_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86XL3	Ankyrin repeat and LEM domain-containing protein 2	LIG_APCC_ABBA_1	824:829	LFLFGE	APC,CDC20,FZR1	0.852	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons