DegronMD

Uniprot ID: Q86XL3

Source protein: Ankyrin repeat and LEM domain-containing protein 2

Source gene: ANKLE2

Class: DEG_SCF_FBW7_2

Location: 538:545

E3 ligase: FBXW7

DEGRON score: 0.9808

ASA_SCORE: 97.4375

COIL: 0.7538

CONS_SCORE: 0.6079

DSS_SCORE: 0.4515

HELIX: 0.2308

FCONS_SCORE: 1.2514

RIG_SCORE: 0.7344

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E533K	TCGA-66-2771	LUSC	TCGA	LWKTPPRE	DEG_SCF_FBW7_2	0.1944
p.E533K	DO26870	LUSC	ICGC	LWKTPPRE	DEG_SCF_FBW7_2	0.1944
p.D534N	TCGA-A7-A56D	BRCA	TCGA	LWKTPPRE	DEG_SCF_FBW7_2	0.2222
p.D534N	DO44165	BRCA	ICGC	LWKTPPRE	DEG_SCF_FBW7_2	0.2222
p.R536H	TCGA-AD-6889	COAD	TCGA	LWKTPPRE	DEG_SCF_FBW7_2	0.2778
p.R536H	DO8463	COAD	ICGC	LWKTPPRE	DEG_SCF_FBW7_2	0.2778
p.R536C	TCGA-AP-A0LM	UCEC	TCGA	LWKTPPRE	DEG_SCF_FBW7_2	0.2778
p.R536C	TCGA-DK-A6AW	BLCA	TCGA	LWKTPPRE	DEG_SCF_FBW7_2	0.2778
p.R536C	DO48566	BLCA	ICGC	LWKTPPRE	DEG_SCF_FBW7_2	0.2778
p.R536C	DO220877	MELA	ICGC	LWKTPPRE	DEG_SCF_FBW7_2	0.2778
p.R536C	DO43306	UCEC	ICGC	LWKTPPRE	DEG_SCF_FBW7_2	0.2778
p.R536C	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	LWKTPPRE	DEG_SCF_FBW7_2	0.2778
p.R536C	ACH-000809	Esophageal Cancer	CCLE	LWKTPPRE	DEG_SCF_FBW7_2	0.2778
p.R536C	KYSE-410	oesophagus	COSMIC	LWKTPPRE	DEG_SCF_FBW7_2	0.2778
p.K537R	TCGA-AR-A1AV	BRCA	TCGA	LWKTPPRE	DEG_SCF_FBW7_2	0.3056
p.K537R	DO4659	BRCA	ICGC	LWKTPPRE	DEG_SCF_FBW7_2	0.3056
p.A547T	TCGA-AX-A06F	UCEC	TCGA	LWKTPPRE	DEG_SCF_FBW7_2	0.2778
p.A547T	DO41752	UCEC	ICGC	LWKTPPRE	DEG_SCF_FBW7_2	0.2778
p.K537T	TCGA-BR-8591	STAD	TCGA	LWKTPPRE	DEG_SCF_FBW7_2	0.3056
p.K537T	DO47973	STAD	ICGC	LWKTPPRE	DEG_SCF_FBW7_2	0.3056
p.L550F	TCGA-EE-A29R	SKCM	TCGA	LWKTPPRE	DEG_SCF_FBW7_2	0.1944
p.L550F	DO37448	SKCM	ICGC	LWKTPPRE	DEG_SCF_FBW7_2	0.1944
p.A547E	DO229015	LICA	ICGC	LWKTPPRE	DEG_SCF_FBW7_2	0.2778
p.K537N	DO45127	LIRI	ICGC	LWKTPPRE	DEG_SCF_FBW7_2	0.3056
p.H551Y	SIDM01695	Acute Myeloid Leukemia	GDSC	LWKTPPRE	DEG_SCF_FBW7_2	0.1667
p.H551Y	ACH-000166	Leukemia	CCLE	LWKTPPRE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86XL3	Ankyrin repeat and LEM domain-containing protein 2	DEG_SCF_FBW7_2	538:545	LWKTPPRE	FBXW7	0.9808	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LWKTPPRE

Degron related mutations and impact score

Drug responses associated with ANKLE2 mutations

All proteins holding degron of LWKTPPRE