DegronMD - P54098(POLG)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P587T	TCGA-18-3416	LUSC	TCGA	PAWTPGPS	DEG_SCF_FBW7_1	583:590	Mutation altering degron motif	0.7031
p.P587T	DO26423	LUSC	ICGC	PAWTPGPS	DEG_SCF_FBW7_1	583:590	Mutation altering degron motif	0.7031
p.P128S	TCGA-AP-A1DK	UCEC	TCGA	PPLY	ITCH	128:131	Mutation altering degron motif	0.6752
p.P128S	DO42033	UCEC	ICGC	PPLY	ITCH	128:131	Mutation altering degron motif	0.6752
p.R579Q	TCGA-AX-A1C5	UCEC	TCGA	PAWTPGPS	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.2222
p.R579Q	DO230342	COCA	ICGC	PAWTPGPS	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.2222
p.R579Q	DO41422	UCEC	ICGC	PAWTPGPS	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.2222
p.Y573H	TCGA-B5-A3FC	UCEC	TCGA	PAWTPGPS	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.0556
p.Y573H	DO232761	PBCA	ICGC	PAWTPGPS	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.0556
p.Y573H	DO41871	UCEC	ICGC	PAWTPGPS	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.0556
p.L576I	TCGA-B6-A0X0	BRCA	TCGA	PAWTPGPS	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.1389
p.L576I	DO1360	BRCA	ICGC	PAWTPGPS	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.1389
p.D582N	DO233760	GACA	ICGC	PAWTPGPS	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.3056
p.R597W	DO233747	GACA	ICGC	PAWTPGPS	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.1389
p.L125M	DO229032	LICA	ICGC	PPLY	ITCH	128:131	Mutation rewiring degron network	0.25
p.H138N	DO229031	LICA	ICGC	PPLY	ITCH	128:131	Mutation rewiring degron network	0.1389
p.R126H	DO23468	LINC	ICGC	PPLY	ITCH	128:131	Mutation rewiring degron network	0.2778
p.R126H	ACH-000997	Colon/Colorectal Cancer	CCLE	PPLY	ITCH	128:131	Mutation rewiring degron network	0.2778
p.R126H	ACH-001061	Colon/Colorectal Cancer	CCLE	PPLY	ITCH	128:131	Mutation rewiring degron network	0.2778
p.L120F	DO38779	STAD	ICGC	PPLY	ITCH	128:131	Mutation rewiring degron network	0.1111
p.G132E	SIDM01203	Other Solid Cancers	GDSC	PPLY	ITCH	128:131	Mutation rewiring degron network	0.3056
p.Y131H	SIDM00211	B-Lymphoblastic Leukemia	GDSC	PPLY	ITCH	128:131	Mutation altering degron motif	0.7229
p.P600S	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	PAWTPGPS	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.0556
p.P600S	ACH-000893	Lung Cancer	CCLE	PAWTPGPS	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.0556
p.P600S	NCI-H1651	lung	COSMIC	PAWTPGPS	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.0556
p.D581G	SIDM00799	Glioblastoma	GDSC	PAWTPGPS	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.2778
p.D581G	ACH-000558	Brain Cancer	CCLE	PAWTPGPS	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.2778
p.D581G	A172	central nervous system	COSMIC	PAWTPGPS	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.2778
p.L592I	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PAWTPGPS	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.2778
p.G588C	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	PAWTPGPS	DEG_SCF_FBW7_1	583:590	Mutation altering degron motif	0.6489
p.R140C	ACH-002069	Bone Cancer	CCLE	PPLY	ITCH	128:131	Mutation rewiring degron network	0.0833

Kaplan plot for POLG in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

POLG

UniProt ID: P54098

Entrez ID: 5428

Protein name: DNA polymerase subunit gamma-1 (EC 2.7.7.7) (Mitochondrial DNA polymerase catalytic subunit) (PolG-alpha)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for POLG in