DegronMD

Uniprot ID: P54098

Source protein: DNA polymerase subunit gamma-1

Source gene: POLG

Class: DEG_SCF_FBW7_1

Location: 583:590

E3 ligase: FBXW7

DEGRON score: 0.8835

ASA_SCORE: 58.2625

COIL: 0.8033

CONS_SCORE: 0.3167

DSS_SCORE: 0.3186

HELIX: 0.1181

FCONS_SCORE: 0.6405

RIG_SCORE: 0.7359

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P587T	TCGA-18-3416	LUSC	TCGA	PAWTPGPS	DEG_SCF_FBW7_1	0.7031
p.P587T	DO26423	LUSC	ICGC	PAWTPGPS	DEG_SCF_FBW7_1	0.7031
p.R579Q	TCGA-AX-A1C5	UCEC	TCGA	PAWTPGPS	DEG_SCF_FBW7_1	0.2222
p.R579Q	DO230342	COCA	ICGC	PAWTPGPS	DEG_SCF_FBW7_1	0.2222
p.R579Q	DO41422	UCEC	ICGC	PAWTPGPS	DEG_SCF_FBW7_1	0.2222
p.Y573H	TCGA-B5-A3FC	UCEC	TCGA	PAWTPGPS	DEG_SCF_FBW7_1	0.0556
p.Y573H	DO232761	PBCA	ICGC	PAWTPGPS	DEG_SCF_FBW7_1	0.0556
p.Y573H	DO41871	UCEC	ICGC	PAWTPGPS	DEG_SCF_FBW7_1	0.0556
p.L576I	TCGA-B6-A0X0	BRCA	TCGA	PAWTPGPS	DEG_SCF_FBW7_1	0.1389
p.L576I	DO1360	BRCA	ICGC	PAWTPGPS	DEG_SCF_FBW7_1	0.1389
p.D582N	DO233760	GACA	ICGC	PAWTPGPS	DEG_SCF_FBW7_1	0.3056
p.R597W	DO233747	GACA	ICGC	PAWTPGPS	DEG_SCF_FBW7_1	0.1389
p.P600S	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	PAWTPGPS	DEG_SCF_FBW7_1	0.0556
p.P600S	ACH-000893	Lung Cancer	CCLE	PAWTPGPS	DEG_SCF_FBW7_1	0.0556
p.P600S	NCI-H1651	lung	COSMIC	PAWTPGPS	DEG_SCF_FBW7_1	0.0556
p.D581G	SIDM00799	Glioblastoma	GDSC	PAWTPGPS	DEG_SCF_FBW7_1	0.2778
p.D581G	ACH-000558	Brain Cancer	CCLE	PAWTPGPS	DEG_SCF_FBW7_1	0.2778
p.D581G	A172	central_nervous_system	COSMIC	PAWTPGPS	DEG_SCF_FBW7_1	0.2778
p.L592I	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PAWTPGPS	DEG_SCF_FBW7_1	0.2778
p.G588C	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	PAWTPGPS	DEG_SCF_FBW7_1	0.6489

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P54098	DNA polymerase subunit gamma-1	DEG_SCF_FBW7_1	583:590	PAWTPGPS	FBXW7	0.8835	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons