DegronMD

Uniprot ID: P02774

Source protein: Vitamin D-binding protein

Source gene: GC

Class: ITCH

Location: 458:461

E3 ligase: ITCH,NEDD4

DEGRON score: 0.8999

ASA_SCORE: 70.6

COIL: 0.7735

CONS_SCORE: 0.5785

DSS_SCORE: 0.1172

HELIX: 0.046

FCONS_SCORE: 1.249

RIG_SCORE: 0.7725

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A458T	DO229213	THCA	ICGC	PPLY	ITCH	0.7139
p.L460M	DO229031	LICA	ICGC	PPLY	ITCH	0.5999
p.E456K	TCGA-AP-A1DV	UCEC	TCGA	PPLY	ITCH	0.2778
p.E456K	DO43186	UCEC	ICGC	PPLY	ITCH	0.2778
p.H464Y	TCGA-CG-5723	STAD	TCGA	PPLY	ITCH	0.25
p.H464Y	DO38376	STAD	ICGC	PPLY	ITCH	0.25
p.H464Y	SIDM00578	Neuroblastoma	GDSC	PPLY	ITCH	0.25
p.H464Y	SIDM00608	Plasma Cell Myeloma	GDSC	PPLY	ITCH	0.25
p.H464Y	SIDM00215	Colorectal Carcinoma	GDSC	PPLY	ITCH	0.25
p.H464Y	SIDM00553	Acute Myeloid Leukemia	GDSC	PPLY	ITCH	0.25
p.H464Y	SIDM00296	Small Cell Lung Carcinoma	GDSC	PPLY	ITCH	0.25
p.H464Y	SIDM00592	Oral Cavity Carcinoma	GDSC	PPLY	ITCH	0.25
p.H464Y	SIDM00492	Glioblastoma	GDSC	PPLY	ITCH	0.25
p.H464Y	SIDM01172	Acute Myeloid Leukemia	GDSC	PPLY	ITCH	0.25
p.H464Y	SIDM00587	Biliary Tract Carcinoma	GDSC	PPLY	ITCH	0.25
p.H464Y	SIDM00251	Gastric Carcinoma	GDSC	PPLY	ITCH	0.25
p.H464Y	SIDM00247	Gastric Carcinoma	GDSC	PPLY	ITCH	0.25
p.H464Y	SIDM00280	Gastric Carcinoma	GDSC	PPLY	ITCH	0.25
p.H464Y	SIDM00241	Breast Carcinoma	GDSC	PPLY	ITCH	0.25
p.H464Y	SIDM00045	Gastric Carcinoma	GDSC	PPLY	ITCH	0.25
p.H464Y	SIDM01470	Acute Myeloid Leukemia	GDSC	PPLY	ITCH	0.25
p.H464Y	SIDM01611	Endometrial Carcinoma	GDSC	PPLY	ITCH	0.25
p.H464Y	SIDM01446	Glioblastoma	GDSC	PPLY	ITCH	0.25
p.H464Y	SIDM01691	Chronic Myelogenous Leukemia	GDSC	PPLY	ITCH	0.25
p.T455K	DO228483	BRCA	ICGC	PPLY	ITCH	0.25

Showing 1 to 25 of 48 entries

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Drug responses associated with GC mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PPLY

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P82914	28S ribosomal protein S15, mitochondrial	ITCH	192:195	PPLY	ITCH,NEDD4	0.8188	More...
Q6DCA0	AMMECR1-like protein	ITCH	303:306	PPLY	ITCH,NEDD4	0.9894	More...
Q86XL3	Ankyrin repeat and LEM domain-containing protein 2	ITCH	196:199	PPLY	ITCH,NEDD4	0.9937	More...
Q8TBH0	Arrestin domain-containing protein 2	ITCH	385:388	PPLY	ITCH,NEDD4	0.9798	More...
Q96B67	Arrestin domain-containing protein 3	ITCH	391:394	PPLY	ITCH,NEDD4	0.9963	More...
Q8NCT1	Arrestin domain-containing protein 4	ITCH	395:398	PPLY	ITCH,NEDD4	0.8354	More...
O95429	BAG family molecular chaperone regulator 4	ITCH	34:37	PPLY	ITCH,NEDD4	0.9898	More...
Q9BXF3	Cat eye syndrome critical region protein 2	ITCH	1137:1140	PPLY	ITCH,NEDD4	0.8075	More...
Q9P209	Centrosomal protein of 72 kDa	ITCH	278:281	PPLY	ITCH,NEDD4	0.7298	More...
Q8NCG7	Diacylglycerol lipase-beta	ITCH	588:591	PPLY	ITCH,NEDD4	0.838	More...
Q13443	Disintegrin and metalloproteinase domain-containing protein 9	ITCH	812:815	PPLY	ITCH,NEDD4	0.9977	More...
Q8TDM6	Disks large homolog 5	ITCH	1166:1169	PPLY	ITCH,NEDD4	0.9662	More...
P54098	DNA polymerase subunit gamma-1	ITCH	128:131	PPLY	ITCH,NEDD4	0.9114	More...
Q7Z6E9	E3 ubiquitin-protein ligase RBBP6	ITCH	562:565	PPLY	ITCH,NEDD4	0.9715	More...
P62508	Estrogen-related receptor gamma	ITCH	82:85	PPLY	ITCH,NEDD4	0.9981	More...
Q99958	Forkhead box protein C2	ITCH	485:488	PPLY	ITCH,NEDD4	0.9946	More...
Q9P0K8	Forkhead box protein J2	ITCH	230:233	PPLY	ITCH,NEDD4	0.8417	More...
Q2KHR3	Glutamine and serine-rich protein 1	ITCH	370:373	PPLY	ITCH,NEDD4	0.8458	More...
Q9H0J4	Glutamine-rich protein 2	ITCH	1404:1407	PPLY	ITCH,NEDD4	0.9172	More...
Q96CC6	Inactive rhomboid protein 1	ITCH	141:144	PPLY	ITCH,NEDD4	0.9927	More...
Q8NDH2	Leucine-rich repeat transmembrane protein CCDC168	ITCH	5560:5563	PPLY	ITCH,NEDD4	0.6888	More...
Q9P2G4	Microtubule-associated protein 10	ITCH	302:305	PPLY	ITCH,NEDD4	0.9678	More...
Q9HB07	MYG1 exonuclease	ITCH	17:20	PPLY	ITCH,NEDD4	0.6345	More...
Q02080	Myocyte-specific enhancer factor 2B	ITCH	198:201	PPLY	ITCH,NEDD4	0.992	More...
Q5VTT5	Myomesin-3	ITCH	824:827	PPLY	ITCH,NEDD4	0.901	More...

Showing 1 to 25 of 51 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPLY

Degron related mutations and impact score

Drug responses associated with GC mutations

All proteins holding degron of PPLY