DegronMD - P02774(GC)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E456K	TCGA-AP-A1DV	UCEC	TCGA	PPLY	ITCH	458:461	Mutation rewiring degron network	0.2778
p.E456K	DO43186	UCEC	ICGC	PPLY	ITCH	458:461	Mutation rewiring degron network	0.2778
p.H464Y	TCGA-CG-5723	STAD	TCGA	PPLY	ITCH	458:461	Mutation rewiring degron network	0.25
p.H464Y	DO38376	STAD	ICGC	PPLY	ITCH	458:461	Mutation rewiring degron network	0.25
p.H464Y	SIDM00578	Neuroblastoma	GDSC	PPLY	ITCH	458:461	Mutation rewiring degron network	0.25
p.H464Y	SIDM00608	Plasma Cell Myeloma	GDSC	PPLY	ITCH	458:461	Mutation rewiring degron network	0.25
p.H464Y	SIDM00215	Colorectal Carcinoma	GDSC	PPLY	ITCH	458:461	Mutation rewiring degron network	0.25
p.H464Y	SIDM00553	Acute Myeloid Leukemia	GDSC	PPLY	ITCH	458:461	Mutation rewiring degron network	0.25
p.H464Y	SIDM00296	Small Cell Lung Carcinoma	GDSC	PPLY	ITCH	458:461	Mutation rewiring degron network	0.25
p.H464Y	SIDM00592	Oral Cavity Carcinoma	GDSC	PPLY	ITCH	458:461	Mutation rewiring degron network	0.25
p.H464Y	SIDM00492	Glioblastoma	GDSC	PPLY	ITCH	458:461	Mutation rewiring degron network	0.25
p.H464Y	SIDM01172	Acute Myeloid Leukemia	GDSC	PPLY	ITCH	458:461	Mutation rewiring degron network	0.25
p.H464Y	SIDM00587	Biliary Tract Carcinoma	GDSC	PPLY	ITCH	458:461	Mutation rewiring degron network	0.25
p.H464Y	SIDM00251	Gastric Carcinoma	GDSC	PPLY	ITCH	458:461	Mutation rewiring degron network	0.25
p.H464Y	SIDM00247	Gastric Carcinoma	GDSC	PPLY	ITCH	458:461	Mutation rewiring degron network	0.25
p.H464Y	SIDM00280	Gastric Carcinoma	GDSC	PPLY	ITCH	458:461	Mutation rewiring degron network	0.25
p.H464Y	SIDM00241	Breast Carcinoma	GDSC	PPLY	ITCH	458:461	Mutation rewiring degron network	0.25
p.H464Y	SIDM00045	Gastric Carcinoma	GDSC	PPLY	ITCH	458:461	Mutation rewiring degron network	0.25
p.H464Y	SIDM01470	Acute Myeloid Leukemia	GDSC	PPLY	ITCH	458:461	Mutation rewiring degron network	0.25
p.H464Y	SIDM01611	Endometrial Carcinoma	GDSC	PPLY	ITCH	458:461	Mutation rewiring degron network	0.25
p.H464Y	SIDM01446	Glioblastoma	GDSC	PPLY	ITCH	458:461	Mutation rewiring degron network	0.25
p.H464Y	SIDM01691	Chronic Myelogenous Leukemia	GDSC	PPLY	ITCH	458:461	Mutation rewiring degron network	0.25
p.T455K	DO228483	BRCA	ICGC	PPLY	ITCH	458:461	Mutation rewiring degron network	0.25
p.T455K	DO230334	COCA	ICGC	PPLY	ITCH	458:461	Mutation rewiring degron network	0.25
p.T455K	DO229016	COCA	ICGC	PPLY	ITCH	458:461	Mutation rewiring degron network	0.25
p.T455K	DO229003	COCA	ICGC	PPLY	ITCH	458:461	Mutation rewiring degron network	0.25
p.T455K	DO229005	COCA	ICGC	PPLY	ITCH	458:461	Mutation rewiring degron network	0.25
p.T455K	DO230659	LAML	ICGC	PPLY	ITCH	458:461	Mutation rewiring degron network	0.25
p.T455K	DO231140	LAML	ICGC	PPLY	ITCH	458:461	Mutation rewiring degron network	0.25
p.T455K	DO229047	LICA	ICGC	PPLY	ITCH	458:461	Mutation rewiring degron network	0.25
p.T455K	DO230931	LUSC	ICGC	PPLY	ITCH	458:461	Mutation rewiring degron network	0.25
p.T455K	DO231102	LUSC	ICGC	PPLY	ITCH	458:461	Mutation rewiring degron network	0.25
p.H464R	DO229010	COCA	ICGC	PPLY	ITCH	458:461	Mutation rewiring degron network	0.25
p.H464R	DO229013	COCA	ICGC	PPLY	ITCH	458:461	Mutation rewiring degron network	0.25
p.H464R	DO229016	COCA	ICGC	PPLY	ITCH	458:461	Mutation rewiring degron network	0.25
p.H464R	DO229003	COCA	ICGC	PPLY	ITCH	458:461	Mutation rewiring degron network	0.25
p.H464R	DO229005	COCA	ICGC	PPLY	ITCH	458:461	Mutation rewiring degron network	0.25
p.D451E	DO229010	COCA	ICGC	PPLY	ITCH	458:461	Mutation rewiring degron network	0.1389
p.D451E	DO229005	COCA	ICGC	PPLY	ITCH	458:461	Mutation rewiring degron network	0.1389
p.D451E	DO229489	LAML	ICGC	PPLY	ITCH	458:461	Mutation rewiring degron network	0.1389
p.D451E	DO228941	LICA	ICGC	PPLY	ITCH	458:461	Mutation rewiring degron network	0.1389
p.D451E	DO230550	LUSC	ICGC	PPLY	ITCH	458:461	Mutation rewiring degron network	0.1389
p.D451E	DO52365	LUSC	ICGC	PPLY	ITCH	458:461	Mutation rewiring degron network	0.1389
p.D451E	DO231007	LUSC	ICGC	PPLY	ITCH	458:461	Mutation rewiring degron network	0.1389
p.L460M	DO229031	LICA	ICGC	PPLY	ITCH	458:461	Mutation altering degron motif	0.5999
p.K448N	DO48719	LIRI	ICGC	PPLY	ITCH	458:461	Mutation rewiring degron network	0.0556
p.A458T	DO229213	THCA	ICGC	PPLY	ITCH	458:461	Mutation altering degron motif	0.7139
p.R467G	ACH-000665	Lung Cancer	CCLE	PPLY	ITCH	458:461	Mutation rewiring degron network	0.1667

Kaplan plot for GC in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GC

UniProt ID: P02774

Entrez ID: 2638

Protein name: Vitamin D-binding protein (DBP) (VDB) (Gc protein-derived macrophage activating factor) (Gc-MAF) (GcMAF) (Gc-globulin) (Group-specific component) (Gc) (Vitamin D-binding protein-macrophage activating factor) (DBP-maf)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GC in