DegronMD

Uniprot ID: Q8WZ42

Source protein: Titin

Source gene: TTN

Class: DEG_APCC_DBOX_1

Location: 5710:5718

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7313

ASA_SCORE: 56.2444

COIL: 0.1596

CONS_SCORE: 0.3691

DSS_SCORE: 0.4633

HELIX: 0.0027

FCONS_SCORE: 0.9506

RIG_SCORE: 0.8318

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C5709R	TCGA-5C-A9VH	LIHC	TCGA	TRVQLKALV	DEG_APCC_DBOX_1	0.3056
p.S5718G	TCGA-61-1733	OV	TCGA	TRVQLKALV	DEG_APCC_DBOX_1	0.6993
p.V5700A	TCGA-66-2791	LUSC	TCGA	TRVQLKALV	DEG_APCC_DBOX_1	0.1667
p.A5722D	TCGA-98-A53B	LUSC	TCGA	TRVQLKALV	DEG_APCC_DBOX_1	0.2222
p.A5702E	TCGA-AF-5654	READ	TCGA	TRVQLKALV	DEG_APCC_DBOX_1	0.1111
p.D5703N	TCGA-AJ-A3QS	UCEC	TCGA	TRVQLKALV	DEG_APCC_DBOX_1	0.1389
p.E5706K	TCGA-AP-A05N	UCEC	TCGA	TRVQLKALV	DEG_APCC_DBOX_1	0.2222
p.E5706K	TCGA-ND-A4WC	UCS	TCGA	TRVQLKALV	DEG_APCC_DBOX_1	0.2222
p.G5716C	TCGA-F4-6570	COAD	TCGA	TRVQLKALV	DEG_APCC_DBOX_1	0.76
p.R5727G	TCGA-FR-A8YC	SKCM	TCGA	TRVQLKALV	DEG_APCC_DBOX_1	0.1944
p.K5715N	DO49898	CESC	ICGC	TRVQLKALV	DEG_APCC_DBOX_1	0.5806
p.S5703P	DO233855	GACA	ICGC	TRVQLKALV	DEG_APCC_DBOX_1	0.1389
p.A5716D	DO228971	LICA	ICGC	TRVQLKALV	DEG_APCC_DBOX_1	0.6682
p.P5708L	DO220911	MELA	ICGC	TRVQLKALV	DEG_APCC_DBOX_1	0.2778
p.K5727T	DO40884	UCEC	ICGC	TRVQLKALV	DEG_APCC_DBOX_1	0.1944
p.P5723S	DO42713	UCEC	ICGC	TRVQLKALV	DEG_APCC_DBOX_1	0.1944
p.V5706A	DO41331	UCEC	ICGC	TRVQLKALV	DEG_APCC_DBOX_1	0.2222
p.V5718M	DO43971	UCEC	ICGC	TRVQLKALV	DEG_APCC_DBOX_1	0.6097
p.P5723Q	ACH-000186	Lung Cancer	CCLE	TRVQLKALV	DEG_APCC_DBOX_1	0.1944
p.D5722Y	NCI-H1568	lung	COSMIC	TRVQLKALV	DEG_APCC_DBOX_1	0.2222
p.G5726E	IGR-37	skin	COSMIC	TRVQLKALV	DEG_APCC_DBOX_1	0.1111
p.P5723H	NCI-H2444	lung	COSMIC	TRVQLKALV	DEG_APCC_DBOX_1	0.1944
p.V5718A	NCI-H446	lung	COSMIC	TRVQLKALV	DEG_APCC_DBOX_1	0.5825
p.C5721R	A253	salivary_gland	COSMIC	TRVQLKALV	DEG_APCC_DBOX_1	0.25
p.K5723N	KE-37	haematopoietic_and_lymphoid_tissue	COSMIC	TRVQLKALV	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WZ42	Titin	DEG_APCC_DBOX_1	5710:5718	TRVQLKALV	APC,CDC20,FZR1	0.7313	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TRVQLKALV

Degron related mutations and impact score

Drug responses associated with TTN mutations

All proteins holding degron of TRVQLKALV