DegronMD

Uniprot ID: Q8WZ42

Source protein: Titin

Source gene: TTN

Class: DEG_SCF_TRCP1_1

Location: 19892:19897

E3 ligase: BTRC

DEGRON score: 0.937

ASA_SCORE: 48.2

COIL: 0.3498

CONS_SCORE: 0.6303

DSS_SCORE: 0.3274

HELIX: 0.0275

FCONS_SCORE: 1.1066

RIG_SCORE: 0.7687

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W19898S	TCGA-52-7810	LUSC	TCGA	DSGYYS	DEG_SCF_TRCP1_1	0.3056
p.L19884Q	TCGA-56-1622	LUSC	TCGA	DSGYYS	DEG_SCF_TRCP1_1	0.1111
p.S19893L	TCGA-EE-A29D	SKCM	TCGA	DSGYYS	DEG_SCF_TRCP1_1	0.8778
p.E19900K	TCGA-FW-A3R5	SKCM	TCGA	DSGYYS	DEG_SCF_TRCP1_1	0.25
p.L19883V	DO51879	BLCA	ICGC	DSGYYS	DEG_SCF_TRCP1_1	0.0833
p.E19901D	DO225295	BRCA	ICGC	DSGYYS	DEG_SCF_TRCP1_1	0.2222
p.D19892N	DO223732	CESC	ICGC	DSGYYS	DEG_SCF_TRCP1_1	0.6932
p.D19892Y	DO222884	COCA	ICGC	DSGYYS	DEG_SCF_TRCP1_1	0.7325
p.W19898C	SIDM02070	Esophageal Carcinoma	GDSC	DSGYYS	DEG_SCF_TRCP1_1	0.3056
p.W19898C	SNU-387	liver	COSMIC	DSGYYS	DEG_SCF_TRCP1_1	0.3056
p.E19885D	SIDM01953	Colorectal Carcinoma	GDSC	DSGYYS	DEG_SCF_TRCP1_1	0.1389
p.T19897N	SU-DHL-6	haematopoietic_and_lymphoid_tissue	COSMIC	DSGYYS	DEG_SCF_TRCP1_1	0.7055
p.S19896P	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	DSGYYS	DEG_SCF_TRCP1_1	0.6752
p.E19902Q	KASUMI-1	haematopoietic_and_lymphoid_tissue	COSMIC	DSGYYS	DEG_SCF_TRCP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WZ42	Titin	DEG_SCF_TRCP1_1	19892:19897	DSGYYS	BTRC	0.937	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons