DegronMD

Uniprot ID: Q8WZ42

Source protein: Titin

Source gene: TTN

Class: DEG_APCC_DBOX_1

Location: 33010:33018

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9827

ASA_SCORE: 83.7444

COIL: 0.7758

CONS_SCORE: 0.3422

DSS_SCORE: 0.2954

HELIX: 0.0738

FCONS_SCORE: 1.03

RIG_SCORE: 0.7116

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q33018K	TCGA-61-1737	OV	TCGA	RRRSLGDIS	DEG_APCC_DBOX_1	0.6944
p.T33016A	TCGA-AX-A2IN	UCEC	TCGA	RRRSLGDIS	DEG_APCC_DBOX_1	0.7139
p.S33011F	TCGA-BA-4077	HNSC	TCGA	RRRSLGDIS	DEG_APCC_DBOX_1	0.7982
p.D33013Y	TCGA-DK-A6AW	BLCA	TCGA	RRRSLGDIS	DEG_APCC_DBOX_1	0.7325
p.L33005H	TCGA-F4-6459	COAD	TCGA	RRRSLGDIS	DEG_APCC_DBOX_1	0.1944
p.L33008F	TCGA-IB-7651	PAAD	TCGA	RRRSLGDIS	DEG_APCC_DBOX_1	0.2778
p.D33002N	DO2401	BRCA	ICGC	RRRSLGDIS	DEG_APCC_DBOX_1	0.1111
p.I33017V	DO234389	ESAD	ICGC	RRRSLGDIS	DEG_APCC_DBOX_1	0.5965
p.Y33003H	DO228239	LICA	ICGC	RRRSLGDIS	DEG_APCC_DBOX_1	0.5833
p.D33004E	DO229026	LICA	ICGC	RRRSLGDIS	DEG_APCC_DBOX_1	0.1667
p.D33002G	DO50710	ORCA	ICGC	RRRSLGDIS	DEG_APCC_DBOX_1	0.1111
p.S33018T	DO31869	OV	ICGC	RRRSLGDIS	DEG_APCC_DBOX_1	0.7116
p.R33008Q	DO227688	SKCA	ICGC	RRRSLGDIS	DEG_APCC_DBOX_1	0.2778
p.P33001S	DO47362	SKCM	ICGC	RRRSLGDIS	DEG_APCC_DBOX_1	0.0833
p.R33011K	DO38016	SKCM	ICGC	RRRSLGDIS	DEG_APCC_DBOX_1	0.7237
p.R33012C	DO38495	STAD	ICGC	RRRSLGDIS	DEG_APCC_DBOX_1	0.719
p.R33012C	DO219765	UCEC	ICGC	RRRSLGDIS	DEG_APCC_DBOX_1	0.719
p.L33014I	DO41572	UCEC	ICGC	RRRSLGDIS	DEG_APCC_DBOX_1	0.7174
p.S33013Y	DO43755	UCEC	ICGC	RRRSLGDIS	DEG_APCC_DBOX_1	0.712
p.S33011T	SIDM00572	Gastric Carcinoma	GDSC	RRRSLGDIS	DEG_APCC_DBOX_1	0.7116
p.S33011T	SIDM00060	Ovarian Carcinoma	GDSC	RRRSLGDIS	DEG_APCC_DBOX_1	0.7116
p.S33011T	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	RRRSLGDIS	DEG_APCC_DBOX_1	0.7116
p.L33008I	SIDM00534	Colorectal Carcinoma	GDSC	RRRSLGDIS	DEG_APCC_DBOX_1	0.2778
p.L33008I	SIDM00118	Colorectal Carcinoma	GDSC	RRRSLGDIS	DEG_APCC_DBOX_1	0.2778
p.L33008I	ACH-000986	Colon/Colorectal Cancer	CCLE	RRRSLGDIS	DEG_APCC_DBOX_1	0.2778
p.L33008I	ACH-001081	Colon/Colorectal Cancer	CCLE	RRRSLGDIS	DEG_APCC_DBOX_1	0.2778
p.L33008I	HCC2998	large_intestine	COSMIC	RRRSLGDIS	DEG_APCC_DBOX_1	0.2778
p.L33008I	HT-115	large_intestine	COSMIC	RRRSLGDIS	DEG_APCC_DBOX_1	0.2778
p.L33024V	ACH-000066	Lung Cancer	CCLE	RRRSLGDIS	DEG_APCC_DBOX_1	0.1667
p.S33018Y	CW-2	large_intestine	COSMIC	RRRSLGDIS	DEG_APCC_DBOX_1	0.712
p.D33016V	DOV13	ovary	COSMIC	RRRSLGDIS	DEG_APCC_DBOX_1	0.6674
p.D33004N	SK-HEP-1	liver	COSMIC	RRRSLGDIS	DEG_APCC_DBOX_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRRSLGDIS

Degron related mutations and impact score

Drug responses associated with TTN mutations

All proteins holding degron of RRRSLGDIS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WZ42	Titin	DEG_APCC_DBOX_1	33010:33018	RRRSLGDIS	APC,CDC20,FZR1	0.9827	More...