DegronMD

Uniprot ID: Q8WZ42

Source protein: Titin

Source gene: TTN

Class: LIG_APCC_ABBA_1

Location: 1843:1848

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9044

ASA_SCORE: 56.8167

COIL: 0.4553

CONS_SCORE: 0.6235

DSS_SCORE: 0.4126

HELIX: 0.0147

FCONS_SCORE: 1.0047

RIG_SCORE: 0.836

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1835K	TCGA-66-2767	LUSC	TCGA	IVLYPE	LIG_APCC_ABBA_1	0.1111
p.Q1835K	DO26713	LUSC	ICGC	IVLYPE	LIG_APCC_ABBA_1	0.1111
p.Q1835K	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	IVLYPE	LIG_APCC_ABBA_1	0.1111
p.Q1835K	SIDM01709	Melanoma	GDSC	IVLYPE	LIG_APCC_ABBA_1	0.1111
p.Q1835K	ACH-000275	Non-Cancerous	CCLE	IVLYPE	LIG_APCC_ABBA_1	0.1111
p.Q1835K	ACH-000916	Lung Cancer	CCLE	IVLYPE	LIG_APCC_ABBA_1	0.1111
p.Q1835K	NCI-H1573	lung	COSMIC	IVLYPE	LIG_APCC_ABBA_1	0.1111
p.D1842N	TCGA-C5-A1BL	CESC	TCGA	IVLYPE	LIG_APCC_ABBA_1	0.3056
p.D1842N	DO48986	CESC	ICGC	IVLYPE	LIG_APCC_ABBA_1	0.3056
p.D1834Y	TCGA-D1-A16X	UCEC	TCGA	IVLYPE	LIG_APCC_ABBA_1	0.0833
p.D1834Y	DO41799	UCEC	ICGC	IVLYPE	LIG_APCC_ABBA_1	0.0833
p.T1833A	DO234187	ESAD	ICGC	IVLYPE	LIG_APCC_ABBA_1	0.5
p.L1853I	DO229035	LICA	ICGC	IVLYPE	LIG_APCC_ABBA_1	0.1944
p.G1855E	DO222753	MELA	ICGC	IVLYPE	LIG_APCC_ABBA_1	0.1389
p.G1855E	SIDM00819	Kidney Carcinoma	GDSC	IVLYPE	LIG_APCC_ABBA_1	0.1389
p.G1855E	ACH-002189	Kidney Cancer	CCLE	IVLYPE	LIG_APCC_ABBA_1	0.1389
p.G1855E	RCC-FG2	kidney	COSMIC	IVLYPE	LIG_APCC_ABBA_1	0.1389
p.E1837G	SIDM00011	Melanoma	GDSC	IVLYPE	LIG_APCC_ABBA_1	0.1667
p.E1837G	ACH-000477	Skin Cancer	CCLE	IVLYPE	LIG_APCC_ABBA_1	0.1667
p.I1853N	RPMI-8402	haematopoietic_and_lymphoid_tissue	COSMIC	IVLYPE	LIG_APCC_ABBA_1	0.1944
p.V1854M	HCC1569	breast	COSMIC	IVLYPE	LIG_APCC_ABBA_1	0.1667
p.S1858L	HCT-15	large_intestine	COSMIC	IVLYPE	LIG_APCC_ABBA_1	0.0556
p.S1838R	KMS-11	haematopoietic_and_lymphoid_tissue	COSMIC	IVLYPE	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WZ42	Titin	LIG_APCC_ABBA_1	1843:1848	IVLYPE	APC,CDC20,FZR1	0.9044	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons