DegronMD

Uniprot ID: Q8WZ42

Source protein: Titin

Source gene: TTN

Class: LIG_APCC_ABBAyCdc20_2

Location: 2874:2880

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6893

ASA_SCORE: 61.3714

COIL: 0.0353

CONS_SCORE: 0.4308

DSS_SCORE: 0.1014

HELIX: 0.0021

FCONS_SCORE: 0.878

RIG_SCORE: 0.903

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L2877R	TCGA-66-2759	LUSC	TCGA	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.8428
p.L2877R	DO27326	LUSC	ICGC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.8428
p.M2877I	K-562	haematopoietic_and_lymphoid_tissue	COSMIC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.7618
p.F2878L	DO230525	LUSC	ICGC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.6981
p.K2876T	TCGA-EO-A22R	UCEC	TCGA	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.6195
p.K2876T	DO42713	UCEC	ICGC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.6195
p.A2875T	SIDM00206	Glioblastoma	GDSC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.6028
p.A2875T	D-566MG	central_nervous_system	COSMIC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.6028
p.K2876E	SIDM01016	T-Lymphoblastic Leukemia	GDSC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.591
p.K2876E	SIDM01263	T-Lymphoblastic Leukemia	GDSC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.591
p.K2876E	ACH-000995	Leukemia	CCLE	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.591
p.K2876E	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.591
p.A2875V	TCGA-YZ-A985	UVM	TCGA	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.5825
p.V2873L	DOHH-2	haematopoietic_and_lymphoid_tissue	COSMIC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.3056
p.H2883N	DO45107	LIRI	ICGC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.25
p.H2883R	SIDM00134	Non-Small Cell Lung Carcinoma	GDSC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.25
p.H2883R	ACH-000825	Lung Cancer	CCLE	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.25
p.H2883R	HOP-92	lung	COSMIC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.25
p.I2884V	TCGA-BP-4167	KIRC	TCGA	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.2222
p.I2884V	DO18799	KIRC	ICGC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.2222
p.K2889N	TCGA-AX-A2HD	UCEC	TCGA	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.1944
p.K2889N	DO42608	UCEC	ICGC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.1944
p.G2869W	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.1944
p.G2869W	ACH-000875	Lung Cancer	CCLE	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.1944
p.G2869W	NCI-H2347	lung	COSMIC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.1944

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Drug responses associated with TTN mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of KAKLFVE

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WZ42	Titin	LIG_APCC_ABBAyCdc20_2	2874:2880	KAKLFVE	APC,CDC20,FZR1	0.6893	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KAKLFVE

Degron related mutations and impact score

Drug responses associated with TTN mutations

All proteins holding degron of KAKLFVE