DegronMD

Uniprot ID: Q8WZ42

Source protein: Titin

Source gene: TTN

Class: LIG_APCC_ABBAyCdc20_2

Location: 2874:2880

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6893

ASA_SCORE: 61.3714

COIL: 0.0353

CONS_SCORE: 0.4308

DSS_SCORE: 0.1014

HELIX: 0.0021

FCONS_SCORE: 0.878

RIG_SCORE: 0.903

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L2877R	TCGA-66-2759	LUSC	TCGA	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.8428
p.L2877R	DO27326	LUSC	ICGC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.8428
p.K2889N	TCGA-AX-A2HD	UCEC	TCGA	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.1944
p.K2889N	DO42608	UCEC	ICGC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.1944
p.I2884V	TCGA-BP-4167	KIRC	TCGA	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.2222
p.I2884V	DO18799	KIRC	ICGC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.2222
p.M2888I	TCGA-D3-A8GI	SKCM	TCGA	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.1111
p.M2888I	DO50284	SKCM	ICGC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.1111
p.K2876T	TCGA-EO-A22R	UCEC	TCGA	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.6195
p.K2876T	DO42713	UCEC	ICGC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.6195
p.A2875V	TCGA-YZ-A985	UVM	TCGA	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.5825
p.H2883N	DO45107	LIRI	ICGC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.25
p.F2878L	DO230525	LUSC	ICGC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.6981
p.K2876E	SIDM01016	T-Lymphoblastic Leukemia	GDSC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.591
p.K2876E	SIDM01263	T-Lymphoblastic Leukemia	GDSC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.591
p.K2876E	ACH-000995	Leukemia	CCLE	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.591
p.K2876E	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.591
p.H2883R	SIDM00134	Non-Small Cell Lung Carcinoma	GDSC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.25
p.H2883R	ACH-000825	Lung Cancer	CCLE	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.25
p.H2883R	HOP-92	lung	COSMIC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.25
p.A2875T	SIDM00206	Glioblastoma	GDSC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.6028
p.A2875T	D-566MG	central_nervous_system	COSMIC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.6028
p.G2869W	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.1944
p.G2869W	ACH-000875	Lung Cancer	CCLE	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.1944
p.G2869W	NCI-H2347	lung	COSMIC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.1944
p.A2866V	ACH-001518	Endometrial/Uterine Cancer	CCLE	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.1111
p.H2890N	NCI-H2342	lung	COSMIC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.0556
p.V2873L	DOHH-2	haematopoietic_and_lymphoid_tissue	COSMIC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.3056
p.M2877I	K-562	haematopoietic_and_lymphoid_tissue	COSMIC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	0.7618

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KAKLFVE

Degron related mutations and impact score

Drug responses associated with TTN mutations

All proteins holding degron of KAKLFVE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WZ42	Titin	LIG_APCC_ABBAyCdc20_2	2874:2880	KAKLFVE	APC,CDC20,FZR1	0.6893	More...