DegronMD

Uniprot ID: Q8WZ42

Source protein: Titin

Source gene: TTN

Class: DEG_SCF_TRCP1_1

Location: 20289:20294

E3 ligase: BTRC

DEGRON score: 0.7991

ASA_SCORE: 53.6167

COIL: 0.4525

CONS_SCORE: 0.6564

DSS_SCORE: 0.3613

HELIX: 0.0493

FCONS_SCORE: 1.0705

RIG_SCORE: 0.7337

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S20291Y	TCGA-AP-A1E0	UCEC	TCGA	DSGDYT	DEG_SCF_TRCP1_1	0.712
p.A20287T	TCGA-DU-6392	LGG	TCGA	DSGDYT	DEG_SCF_TRCP1_1	0.2778
p.G20299S	TCGA-MX-A5UJ	STAD	TCGA	DSGDYT	DEG_SCF_TRCP1_1	0.1944
p.E20285K	TCGA-W3-A825	SKCM	TCGA	DSGDYT	DEG_SCF_TRCP1_1	0.2222
p.T20304P	TCGA-WE-A8ZN	SKCM	TCGA	DSGDYT	DEG_SCF_TRCP1_1	0.5
p.T20294N	DO222798	COCA	ICGC	DSGDYT	DEG_SCF_TRCP1_1	0.7055
p.V20285M	DO50395	ESAD	ICGC	DSGDYT	DEG_SCF_TRCP1_1	0.2222
p.N20286K	DO229019	LICA	ICGC	DSGDYT	DEG_SCF_TRCP1_1	0.25
p.Y20293H	DO24692	LUAD	ICGC	DSGDYT	DEG_SCF_TRCP1_1	0.6118
p.S20303C	DO26520	LUSC	ICGC	DSGDYT	DEG_SCF_TRCP1_1	0.0833
p.G20291E	DO222536	MELA	ICGC	DSGDYT	DEG_SCF_TRCP1_1	0.7199
p.R20287W	201T	lung	COSMIC	DSGDYT	DEG_SCF_TRCP1_1	0.2778
p.R20287K	Mewo	skin	COSMIC	DSGDYT	DEG_SCF_TRCP1_1	0.2778
p.V20285L	LS-411N	large_intestine	COSMIC	DSGDYT	DEG_SCF_TRCP1_1	0.2222
p.D20281N	K2	skin	COSMIC	DSGDYT	DEG_SCF_TRCP1_1	0.1111
p.D20297N	COLO-792	skin	COSMIC	DSGDYT	DEG_SCF_TRCP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WZ42	Titin	DEG_SCF_TRCP1_1	20289:20294	DSGDYT	BTRC	0.7991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons