DegronMD

Uniprot ID: Q8WZ42

Source protein: Titin

Source gene: TTN

Class: DEG_COP1_1

Location: 18124:18133

E3 ligase: COP1

DEGRON score: 0.9328

ASA_SCORE: 77.87

COIL: 0.7776

CONS_SCORE: 0.6014

DSS_SCORE: 0.451

HELIX: 0.0139

FCONS_SCORE: 0.8958

RIG_SCORE: 0.6925

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G18135C	TCGA-09-2044	OV	TCGA	ESDPAHVPEP	DEG_COP1_1	0.2778
p.R18140Q	TCGA-34-2596	LUSC	TCGA	ESDPAHVPEP	DEG_COP1_1	0.1389
p.R18140Q	TCGA-E7-A6MD	BLCA	TCGA	ESDPAHVPEP	DEG_COP1_1	0.1389
p.P18133H	TCGA-60-2720	LUSC	TCGA	ESDPAHVPEP	DEG_COP1_1	0.7694
p.Q18136H	TCGA-63-5128	LUSC	TCGA	ESDPAHVPEP	DEG_COP1_1	0.25
p.E18123D	TCGA-AA-3977	COAD	TCGA	ESDPAHVPEP	DEG_COP1_1	0.3056
p.A18121D	TCGA-AP-A1DK	UCEC	TCGA	ESDPAHVPEP	DEG_COP1_1	0.25
p.R18125K	TCGA-FR-A726	SKCM	TCGA	ESDPAHVPEP	DEG_COP1_1	0.7237
p.E18124Q	DO225190	BRCA	ICGC	ESDPAHVPEP	DEG_COP1_1	0.6744
p.E18124Q	DO227561	BRCA	ICGC	ESDPAHVPEP	DEG_COP1_1	0.6744
p.P18142T	DO234401	ESAD	ICGC	ESDPAHVPEP	DEG_COP1_1	0.0833
p.P18131S	DO11848	GBM	ICGC	ESDPAHVPEP	DEG_COP1_1	0.6752
p.A18121E	DO229027	LICA	ICGC	ESDPAHVPEP	DEG_COP1_1	0.25
p.A18128D	DO229031	LICA	ICGC	ESDPAHVPEP	DEG_COP1_1	0.6682
p.A18118E	DO229037	LICA	ICGC	ESDPAHVPEP	DEG_COP1_1	0.1667
p.P18131L	DO222423	MELA	ICGC	ESDPAHVPEP	DEG_COP1_1	0.7582
p.P18131L	DO37425	SKCM	ICGC	ESDPAHVPEP	DEG_COP1_1	0.7582
p.A18128V	DO29006	OV	ICGC	ESDPAHVPEP	DEG_COP1_1	0.5825
p.D18126Y	DO36556	READ	ICGC	ESDPAHVPEP	DEG_COP1_1	0.7325
p.V18136L	ACH-000699	Breast Cancer	CCLE	ESDPAHVPEP	DEG_COP1_1	0.25
p.V18136L	HCC1395	breast	COSMIC	ESDPAHVPEP	DEG_COP1_1	0.25
p.T18138S	CW-2	large_intestine	COSMIC	ESDPAHVPEP	DEG_COP1_1	0.1944
p.N18120S	P12-ICHIKAWA	haematopoietic_and_lymphoid_tissue	COSMIC	ESDPAHVPEP	DEG_COP1_1	0.2222
p.N18120S	HUH-6-clone5	liver	COSMIC	ESDPAHVPEP	DEG_COP1_1	0.2222
p.N18120S	MY-M12	haematopoietic_and_lymphoid_tissue	COSMIC	ESDPAHVPEP	DEG_COP1_1	0.2222
p.P18131Q	NCI-H1836	lung	COSMIC	ESDPAHVPEP	DEG_COP1_1	0.7035
p.P18123T	NCI-H1793	lung	COSMIC	ESDPAHVPEP	DEG_COP1_1	0.3056
p.P18136L	NCI-H630	large_intestine	COSMIC	ESDPAHVPEP	DEG_COP1_1	0.25
p.P18118S	Sarc9371	bone	COSMIC	ESDPAHVPEP	DEG_COP1_1	0.1667
p.P18129Q	RT4	urinary_tract	COSMIC	ESDPAHVPEP	DEG_COP1_1	0.7035
p.K18114M	H2591	pleura	COSMIC	ESDPAHVPEP	DEG_COP1_1	0.0556
p.P18118L	Sarc9371	bone	COSMIC	ESDPAHVPEP	DEG_COP1_1	0.1667
p.T18142A	SNU-81	large_intestine	COSMIC	ESDPAHVPEP	DEG_COP1_1	0.0833
p.D18125E	VMRC-RCZ	kidney	COSMIC	ESDPAHVPEP	DEG_COP1_1	0.6758

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ESDPAHVPEP

Degron related mutations and impact score

Drug responses associated with TTN mutations

All proteins holding degron of ESDPAHVPEP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WZ42	Titin	DEG_COP1_1	18124:18133	ESDPAHVPEP	COP1	0.9328	More...