DegronMD

Uniprot ID: Q8WZ42

Source protein: Titin

Source gene: TTN

Class: DEG_COP1_1

Location: 18124:18133

E3 ligase: COP1

DEGRON score: 0.9328

ASA_SCORE: 77.87

COIL: 0.7776

CONS_SCORE: 0.6014

DSS_SCORE: 0.451

HELIX: 0.0139

FCONS_SCORE: 0.8958

RIG_SCORE: 0.6925

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P18133H	TCGA-60-2720	LUSC	TCGA	ESDPAHVPEP	DEG_COP1_1	0.7694
p.P18131L	DO222423	MELA	ICGC	ESDPAHVPEP	DEG_COP1_1	0.7582
p.P18131L	DO37425	SKCM	ICGC	ESDPAHVPEP	DEG_COP1_1	0.7582
p.D18126Y	DO36556	READ	ICGC	ESDPAHVPEP	DEG_COP1_1	0.7325
p.R18125K	TCGA-FR-A726	SKCM	TCGA	ESDPAHVPEP	DEG_COP1_1	0.7237
p.P18131Q	NCI-H1836	lung	COSMIC	ESDPAHVPEP	DEG_COP1_1	0.7035
p.P18129Q	RT4	urinary_tract	COSMIC	ESDPAHVPEP	DEG_COP1_1	0.7035
p.D18125E	VMRC-RCZ	kidney	COSMIC	ESDPAHVPEP	DEG_COP1_1	0.6758
p.P18131S	DO11848	GBM	ICGC	ESDPAHVPEP	DEG_COP1_1	0.6752
p.E18124Q	DO225190	BRCA	ICGC	ESDPAHVPEP	DEG_COP1_1	0.6744
p.E18124Q	DO227561	BRCA	ICGC	ESDPAHVPEP	DEG_COP1_1	0.6744
p.A18128D	DO229031	LICA	ICGC	ESDPAHVPEP	DEG_COP1_1	0.6682
p.A18128V	DO29006	OV	ICGC	ESDPAHVPEP	DEG_COP1_1	0.5825
p.E18123D	TCGA-AA-3977	COAD	TCGA	ESDPAHVPEP	DEG_COP1_1	0.3056
p.P18123T	NCI-H1793	lung	COSMIC	ESDPAHVPEP	DEG_COP1_1	0.3056
p.G18135C	TCGA-09-2044	OV	TCGA	ESDPAHVPEP	DEG_COP1_1	0.2778
p.Q18136H	TCGA-63-5128	LUSC	TCGA	ESDPAHVPEP	DEG_COP1_1	0.25
p.A18121D	TCGA-AP-A1DK	UCEC	TCGA	ESDPAHVPEP	DEG_COP1_1	0.25
p.A18121E	DO229027	LICA	ICGC	ESDPAHVPEP	DEG_COP1_1	0.25
p.V18136L	ACH-000699	Breast Cancer	CCLE	ESDPAHVPEP	DEG_COP1_1	0.25
p.V18136L	HCC1395	breast	COSMIC	ESDPAHVPEP	DEG_COP1_1	0.25
p.P18136L	NCI-H630	large_intestine	COSMIC	ESDPAHVPEP	DEG_COP1_1	0.25
p.N18120S	P12-ICHIKAWA	haematopoietic_and_lymphoid_tissue	COSMIC	ESDPAHVPEP	DEG_COP1_1	0.2222
p.N18120S	HUH-6-clone5	liver	COSMIC	ESDPAHVPEP	DEG_COP1_1	0.2222
p.N18120S	MY-M12	haematopoietic_and_lymphoid_tissue	COSMIC	ESDPAHVPEP	DEG_COP1_1	0.2222

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WZ42	Titin	DEG_COP1_1	18124:18133	ESDPAHVPEP	COP1	0.9328	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons