DegronMD

Uniprot ID: Q8WZ42

Source protein: Titin

Source gene: TTN

Class: DEG_SCF_FBW7_2

Location: 7408:7415

E3 ligase: FBXW7

DEGRON score: 0.6219

ASA_SCORE: 69.4875

COIL: 0.7476

CONS_SCORE: 0.3024

DSS_SCORE: 0.1867

HELIX: 0.0065

FCONS_SCORE: 1.0124

RIG_SCORE: 0.7779

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G7402E	TCGA-19-5956	GBM	TCGA	ISGTPPFE	DEG_SCF_FBW7_2	0.1667
p.R7423T	TCGA-55-8089	LUAD	TCGA	ISGTPPFE	DEG_SCF_FBW7_2	0.2222
p.R7423T	SIDM00525	Osteosarcoma	GDSC	ISGTPPFE	DEG_SCF_FBW7_2	0.2222
p.R7423T	MG-63	bone	COSMIC	ISGTPPFE	DEG_SCF_FBW7_2	0.2222
p.L7417V	TCGA-77-8128	LUSC	TCGA	ISGTPPFE	DEG_SCF_FBW7_2	0.2778
p.P7418S	TCGA-A5-A0G2	UCEC	TCGA	ISGTPPFE	DEG_SCF_FBW7_2	0.25
p.P7418S	TCGA-CD-A486	STAD	TCGA	ISGTPPFE	DEG_SCF_FBW7_2	0.25
p.P7418S	SIDM01750	Melanoma	GDSC	ISGTPPFE	DEG_SCF_FBW7_2	0.25
p.P7418S	ACH-000801	Skin Cancer	CCLE	ISGTPPFE	DEG_SCF_FBW7_2	0.25
p.R7411I	TCGA-BK-A6W3	UCEC	TCGA	ISGTPPFE	DEG_SCF_FBW7_2	0.8102
p.R7411G	TCGA-CN-6024	HNSC	TCGA	ISGTPPFE	DEG_SCF_FBW7_2	0.7568
p.S7400T	TCGA-CQ-6225	HNSC	TCGA	ISGTPPFE	DEG_SCF_FBW7_2	0.1111
p.R7411K	TCGA-CV-A6K2	HNSC	TCGA	ISGTPPFE	DEG_SCF_FBW7_2	0.7237
p.R7411K	SIDM00780	Colorectal Carcinoma	GDSC	ISGTPPFE	DEG_SCF_FBW7_2	0.7237
p.R7411K	ACH-000967	Colon/Colorectal Cancer	CCLE	ISGTPPFE	DEG_SCF_FBW7_2	0.7237
p.E7414K	TCGA-D6-A6EQ	HNSC	TCGA	ISGTPPFE	DEG_SCF_FBW7_2	0.7022
p.E7398K	TCGA-EE-A2MT	SKCM	TCGA	ISGTPPFE	DEG_SCF_FBW7_2	0.1667
p.N7399I	TCGA-OD-A75X	SKCM	TCGA	ISGTPPFE	DEG_SCF_FBW7_2	0.0833
p.V7419I	DO52706	CLLE	ICGC	ISGTPPFE	DEG_SCF_FBW7_2	0.2222
p.Q7405K	DO52060	HNSC	ICGC	ISGTPPFE	DEG_SCF_FBW7_2	0.25
p.G7399V	DO22592	LGG	ICGC	ISGTPPFE	DEG_SCF_FBW7_2	0.0833
p.L7404V	DO27723	LUSC	ICGC	ISGTPPFE	DEG_SCF_FBW7_2	0.2222
p.R7422Q	DO222395	MELA	ICGC	ISGTPPFE	DEG_SCF_FBW7_2	0.1389
p.R7422Q	DO229456	SKCA	ICGC	ISGTPPFE	DEG_SCF_FBW7_2	0.1389
p.R7422Q	DO47700	SKCM	ICGC	ISGTPPFE	DEG_SCF_FBW7_2	0.1389
p.R7422Q	DO47442	SKCM	ICGC	ISGTPPFE	DEG_SCF_FBW7_2	0.1389
p.D7421N	DO222702	MELA	ICGC	ISGTPPFE	DEG_SCF_FBW7_2	0.1667
p.G7410E	DO222714	MELA	ICGC	ISGTPPFE	DEG_SCF_FBW7_2	0.6087
p.Q7424K	DO220011	SARC	ICGC	ISGTPPFE	DEG_SCF_FBW7_2	0.0833
p.E7407K	DO37996	SKCM	ICGC	ISGTPPFE	DEG_SCF_FBW7_2	0.3056
p.E7407K	DO219501	SKCM	ICGC	ISGTPPFE	DEG_SCF_FBW7_2	0.3056
p.K7423N	DO41752	UCEC	ICGC	ISGTPPFE	DEG_SCF_FBW7_2	0.2222
p.V7417L	DO41331	UCEC	ICGC	ISGTPPFE	DEG_SCF_FBW7_2	0.2778
p.S7405Y	SIDM00193	Colorectal Carcinoma	GDSC	ISGTPPFE	DEG_SCF_FBW7_2	0.25
p.S7405Y	ACH-000991	Colon/Colorectal Cancer	CCLE	ISGTPPFE	DEG_SCF_FBW7_2	0.25
p.S7405Y	SNU-81	large_intestine	COSMIC	ISGTPPFE	DEG_SCF_FBW7_2	0.25
p.V7409I	SNU-C2B	large_intestine	COSMIC	ISGTPPFE	DEG_SCF_FBW7_2	0.7076
p.F7414Y	SNU-283	large_intestine	COSMIC	ISGTPPFE	DEG_SCF_FBW7_2	0.6417
p.E7415V	SNU-1040	large_intestine	COSMIC	ISGTPPFE	DEG_SCF_FBW7_2	0.7693
p.K7402N	CW-2	large_intestine	COSMIC	ISGTPPFE	DEG_SCF_FBW7_2	0.1667
p.G7413A	HCC1395	breast	COSMIC	ISGTPPFE	DEG_SCF_FBW7_2	0.754
p.L7418F	NCI-H1155	lung	COSMIC	ISGTPPFE	DEG_SCF_FBW7_2	0.25
p.T7398N	EPLC-272H	lung	COSMIC	ISGTPPFE	DEG_SCF_FBW7_2	0.1667
p.I7420V	NCI-H292	lung	COSMIC	ISGTPPFE	DEG_SCF_FBW7_2	0.3056
p.T7420A	TGBC11TKB	stomach	COSMIC	ISGTPPFE	DEG_SCF_FBW7_2	0.3056
p.I7417M	HCC202	breast	COSMIC	ISGTPPFE	DEG_SCF_FBW7_2	0.2778
p.G7413E	KYSE-270	oesophagus	COSMIC	ISGTPPFE	DEG_SCF_FBW7_2	0.7199
p.P7409L	LNZTA3WT4	central_nervous_system	COSMIC	ISGTPPFE	DEG_SCF_FBW7_2	0.7582
p.G7400E	Mewo	skin	COSMIC	ISGTPPFE	DEG_SCF_FBW7_2	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ISGTPPFE

Degron related mutations and impact score

Drug responses associated with TTN mutations

All proteins holding degron of ISGTPPFE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WZ42	Titin	DEG_SCF_FBW7_2	7408:7415	ISGTPPFE	FBXW7	0.6219	More...