DegronMD

Uniprot ID: Q8WZ42

Source protein: Titin

Source gene: TTN

Class: DEG_SCF_SKP2-CKS1_1

Location: 11528:11535

E3 ligase: SKP2,CSK1

DEGRON score: 0.9857

ASA_SCORE: 106.725

COIL: 0.9484

CONS_SCORE: 0.3411

DSS_SCORE: 0.5107

HELIX: 0.014

FCONS_SCORE: 0.9904

RIG_SCORE: 0.6427

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R11524Q	TCGA-A5-A2K5	UCEC	TCGA	KPEVTPVK	DEG_SCF_SKP2-CKS1_1	0.2222
p.K11519N	TCGA-AA-3715	COAD	TCGA	KPEVTPVK	DEG_SCF_SKP2-CKS1_1	0.1944
p.E11521K	TCGA-EE-A2GN	SKCM	TCGA	KPEVTPVK	DEG_SCF_SKP2-CKS1_1	0.1389
p.A11523S	DO225331	BRCA	ICGC	KPEVTPVK	DEG_SCF_SKP2-CKS1_1	0.1944
p.A11524P	DO8200	COAD	ICGC	KPEVTPVK	DEG_SCF_SKP2-CKS1_1	0.2222
p.P11545A	DO49785	KIRP	ICGC	KPEVTPVK	DEG_SCF_SKP2-CKS1_1	0.0556
p.P11533T	DO228948	LICA	ICGC	KPEVTPVK	DEG_SCF_SKP2-CKS1_1	0.7031
p.A11523V	DO228967	LICA	ICGC	KPEVTPVK	DEG_SCF_SKP2-CKS1_1	0.1944
p.P11522Q	DO228976	LICA	ICGC	KPEVTPVK	DEG_SCF_SKP2-CKS1_1	0.1667
p.P11525S	DO51237	SKCM	ICGC	KPEVTPVK	DEG_SCF_SKP2-CKS1_1	0.25
p.A11524T	DO229248	THCA	ICGC	KPEVTPVK	DEG_SCF_SKP2-CKS1_1	0.2222
p.V11534A	DO219773	UCEC	ICGC	KPEVTPVK	DEG_SCF_SKP2-CKS1_1	0.5825
p.E11522D	SIDM01055	Glioblastoma	GDSC	KPEVTPVK	DEG_SCF_SKP2-CKS1_1	0.1667
p.E11522D	SIDM00094	Kidney Carcinoma	GDSC	KPEVTPVK	DEG_SCF_SKP2-CKS1_1	0.1667
p.E11522D	SIDM00224	Mesothelioma	GDSC	KPEVTPVK	DEG_SCF_SKP2-CKS1_1	0.1667
p.I11525V	SIDM00901	Endometrial Carcinoma	GDSC	KPEVTPVK	DEG_SCF_SKP2-CKS1_1	0.25
p.I11525V	ACH-000940	Endometrial/Uterine Cancer	CCLE	KPEVTPVK	DEG_SCF_SKP2-CKS1_1	0.25
p.I11525V	AN3-CA	endometrium	COSMIC	KPEVTPVK	DEG_SCF_SKP2-CKS1_1	0.25
p.D11544G	SNU-1040	large_intestine	COSMIC	KPEVTPVK	DEG_SCF_SKP2-CKS1_1	0.0833
p.P11522T	CAL-72	bone	COSMIC	KPEVTPVK	DEG_SCF_SKP2-CKS1_1	0.1667
p.K11545R	SNU-C5	large_intestine	COSMIC	KPEVTPVK	DEG_SCF_SKP2-CKS1_1	0.0556
p.L11531I	SNU-81	large_intestine	COSMIC	KPEVTPVK	DEG_SCF_SKP2-CKS1_1	0.7174

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WZ42	Titin	DEG_SCF_SKP2-CKS1_1	11528:11535	KPEVTPVK	SKP2,CSK1	0.9857	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons