DegronMD

Uniprot ID: Q8WZ42

Source protein: Titin

Source gene: TTN

Class: DEG_SCF_FBW7_1

Location: 16765:16770

E3 ligase: FBXW7

DEGRON score: 0.6585

ASA_SCORE: 62.15

COIL: 0.5862

CONS_SCORE: 0.6589

DSS_SCORE: 0.47

HELIX: 0.0157

FCONS_SCORE: 1.2533

RIG_SCORE: 0.6801

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P16755A	TCGA-06-0122	GBM	TCGA	PTPKSS	DEG_SCF_FBW7_1	0.0556
p.G16780V	TCGA-56-A49D	LUSC	TCGA	PTPKSS	DEG_SCF_FBW7_1	0.0556
p.R16766P	TCGA-66-2778	LUSC	TCGA	PTPKSS	DEG_SCF_FBW7_1	0.7512
p.A16759T	TCGA-AG-A002	READ	TCGA	PTPKSS	DEG_SCF_FBW7_1	0.1667
p.A16759T	SIDM00845	Burkitt's Lymphoma	GDSC	PTPKSS	DEG_SCF_FBW7_1	0.1667
p.A16759T	ACH-000786	Lymphoma	CCLE	PTPKSS	DEG_SCF_FBW7_1	0.1667
p.D16762V	TCGA-AJ-A3EK	UCEC	TCGA	PTPKSS	DEG_SCF_FBW7_1	0.3611
p.R16766Q	TCGA-AX-A0J0	UCEC	TCGA	PTPKSS	DEG_SCF_FBW7_1	0.7329
p.R16766Q	TCGA-B5-A1MR	UCEC	TCGA	PTPKSS	DEG_SCF_FBW7_1	0.7329
p.R16766Q	TCGA-D1-A17Q	UCEC	TCGA	PTPKSS	DEG_SCF_FBW7_1	0.7329
p.R16766Q	TCGA-FW-A3R5	SKCM	TCGA	PTPKSS	DEG_SCF_FBW7_1	0.7329
p.P16767Q	DO219083	BLCA	ICGC	PTPKSS	DEG_SCF_FBW7_1	0.7035
p.E16772Q	DO8954	COAD	ICGC	PTPKSS	DEG_SCF_FBW7_1	0.2778
p.R16764H	DO8722	COAD	ICGC	PTPKSS	DEG_SCF_FBW7_1	0.3056
p.R16764C	DO233261	GACA	ICGC	PTPKSS	DEG_SCF_FBW7_1	0.3056
p.R16764C	DO38300	STAD	ICGC	PTPKSS	DEG_SCF_FBW7_1	0.3056
p.T16766K	DO228948	LICA	ICGC	PTPKSS	DEG_SCF_FBW7_1	0.7306
p.R16764S	DO229025	LICA	ICGC	PTPKSS	DEG_SCF_FBW7_1	0.3056
p.G16775E	DO23759	LUAD	ICGC	PTPKSS	DEG_SCF_FBW7_1	0.1944
p.R16764L	DO45317	LUAD	ICGC	PTPKSS	DEG_SCF_FBW7_1	0.3056
p.G16763R	DO26444	LUSC	ICGC	PTPKSS	DEG_SCF_FBW7_1	0.2778
p.G16763R	DO51250	SKCM	ICGC	PTPKSS	DEG_SCF_FBW7_1	0.2778
p.D16774N	DO45451	LUSC	ICGC	PTPKSS	DEG_SCF_FBW7_1	0.2222
p.S16769L	DO49416	PAAD	ICGC	PTPKSS	DEG_SCF_FBW7_1	0.6556
p.S16769L	DO34496	PACA	ICGC	PTPKSS	DEG_SCF_FBW7_1	0.6556
p.K16778N	DO47721	STAD	ICGC	PTPKSS	DEG_SCF_FBW7_1	0.2222
p.K16778N	DO41758	UCEC	ICGC	PTPKSS	DEG_SCF_FBW7_1	0.2222
p.A16757T	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PTPKSS	DEG_SCF_FBW7_1	0.1111
p.A16757T	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PTPKSS	DEG_SCF_FBW7_1	0.1111
p.A16757T	ACH-000995	Leukemia	CCLE	PTPKSS	DEG_SCF_FBW7_1	0.1111
p.A16757T	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PTPKSS	DEG_SCF_FBW7_1	0.1111
p.G16780R	SIDM00839	Colorectal Carcinoma	GDSC	PTPKSS	DEG_SCF_FBW7_1	0.0556
p.G16780R	ACH-000950	Colon/Colorectal Cancer	CCLE	PTPKSS	DEG_SCF_FBW7_1	0.0556
p.G16780R	LoVo	large_intestine	COSMIC	PTPKSS	DEG_SCF_FBW7_1	0.0556
p.W16771R	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	PTPKSS	DEG_SCF_FBW7_1	0.3056
p.R16768H	22RV1	prostate	COSMIC	PTPKSS	DEG_SCF_FBW7_1	0.8244

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTPKSS

Degron related mutations and impact score

Drug responses associated with TTN mutations

All proteins holding degron of PTPKSS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WZ42	Titin	DEG_SCF_FBW7_1	16765:16770	PTPKSS	FBXW7	0.6585	More...